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Found 398 with Last Name = 'la colla' and Initial = 'p'
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50008294(2-(4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)m...)
Affinity DataKi:  95nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50077837(3-(3-Chloro-4-hydroxy-phenyl)-3-hydroxy-6-nitro-3H...)
Affinity DataKi:  250nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM18763(1,8-naphthalein derivative, 10 | 4,4-bis(3-chloro-...)
Affinity DataKi:  700nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50077852(6-Chloro-3,3-bis-(4-hydroxy-phenyl)-3H-benzo[de]is...)
Affinity DataKi:  700nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM18764(1,8-naphthalein derivative, 11 | 8-chloro-4,4-bis(...)
Affinity DataKi:  730nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50077849(3,3-Bis-(4-hydroxy-phenyl)-6-nitro-3H-benzo[de]iso...)
Affinity DataKi:  1.00E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50077838(3,3-Bis-(3-fluoro-4-hydroxy-phenyl)-3H-naphtho[2,3...)
Affinity DataKi:  1.50E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50077836(7,7-Bis-(4-hydroxy-phenyl)-2,7-dihydro-1H-6-oxa-cy...)
Affinity DataKi:  1.50E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50077847(3-(4-Hydroxy-naphthalen-1-yl)-3-(4-hydroxy-phenyl)...)
Affinity DataKi:  1.50E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50077850(3,3-Bis-(3-chloro-4-hydroxy-phenyl)-3H-naphtho[2,3...)
Affinity DataKi:  1.50E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM18769(1,8-naphthalein derivative, 17 | 4,4-bis(3-fluoro-...)
Affinity DataKi:  1.60E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50077841(6-Bromo-3,3-bis-(4-hydroxy-phenyl)-3H-benzo[de]iso...)
Affinity DataKi:  1.70E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50077845(3,3-Bis-(3-chloro-4-hydroxy-phenyl)-3H-isobenzofur...)
Affinity DataKi:  1.90E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50077848(3,3-Bis-(4-hydroxy-phenyl)-3H-benzo[de]isochromen-...)
Affinity DataKi:  2.80E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50077844(3,3-Bis-(4-hydroxy-phenyl)-3H-isobenzofuran-1-one ...)
Affinity DataKi:  4.70E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50077846(6-Bromo-3,3-bis-(3-chloro-4-hydroxy-phenyl)-3H-ben...)
Affinity DataKi:  6.30E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50077851(3,3-Bis-(4-hydroxy-phenyl)-3H-naphtho[2,3-c]furan-...)
Affinity DataKi:  7.00E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50077839(3-Hydroxy-3-(2-hydroxy-3-isopropyl-6-methyl-phenyl...)
Affinity DataKi:  2.60E+4nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50077843(3-Hydroxy-3-(2-hydroxy-phenyl)-3H-benzo[de]isochro...)
Affinity DataKi:  1.05E+5nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM50077840(3-Hydroxy-3-(2-propoxy-phenyl)-3H-benzo[de]isochro...)
Affinity DataKi:  2.96E+5nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of wild-type HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Sapienza University of Rome

LigandPNGBDBM2325(2-(cyclopentylsulfanyl)-6-[1-(2,6-difluorophenyl)e...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration required to inhibit the HIV-1 reverse transcriptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2325(2-(cyclopentylsulfanyl)-6-[1-(2,6-difluorophenyl)e...)
Affinity DataIC50:  5nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  14nMAssay Description:Inhibition of HIV1 recombinant wild type reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Sapienza University of Rome

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against HIV-1 wild type reverse transcriptase (IIIB)More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2323(6-[1-(2,6-difluorophenyl)ethyl]-5-methyl-2-(propan...)
Affinity DataIC50:  19nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  20nMAssay Description:Inhibition of HIV1 virion-associated reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2324(2-(butan-2-ylsulfanyl)-6-[1-(2,6-difluorophenyl)et...)
Affinity DataIC50:  20nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Sapienza University of Rome

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  20nMAssay Description:Inhibitory concentration against HIV-1 mutant reverse transcriptase (Y181C)More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2322(6-[1-(2,6-difluorophenyl)ethyl]-5-methyl-2-(methyl...)
Affinity DataIC50:  20nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2278(3-(benzenesulfonyl)-5-chloro-1H-indole-2-carboxami...)
Affinity DataIC50:  25nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Sapienza University of Rome

LigandPNGBDBM2486(2-(cyclopentylamino)-6-[(2,6-difluorophenyl)methyl...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration required to inhibit the HIV-1 reverse transcriptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Sapienza University of Rome

LigandPNGBDBM2321(2-(cyclopentylsulfanyl)-6-[1-(2,6-difluorophenyl)e...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration required to inhibit the HIV-1 reverse transcriptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2486(2-(cyclopentylamino)-6-[(2,6-difluorophenyl)methyl...)
Affinity DataIC50:  30nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2482(5-Chloro-3-[(3,5-dimethylphenyl)sulfonyl]-1H-indol...)
Affinity DataIC50:  31nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  33nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2488(2-(cyclopentylamino)-6-[1-(2,6-difluorophenyl)ethy...)
Affinity DataIC50:  35nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Sapienza University of Rome

LigandPNGBDBM2488(2-(cyclopentylamino)-6-[1-(2,6-difluorophenyl)ethy...)
Affinity DataIC50:  35nMAssay Description:Inhibitory concentration required to inhibit the HIV-1 reverse transcriptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Sapienza University of Rome

LigandPNGBDBM2487(2-(cyclopentylamino)-6-[1-(2,6-difluorophenyl)ethy...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration required to inhibit the HIV-1 reverse transcriptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2337(6-benzyl-1-(ethoxymethyl)-5-(propan-2-yl)-1,2,3,4-...)
Affinity DataIC50:  40nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2487(2-(cyclopentylamino)-6-[1-(2,6-difluorophenyl)ethy...)
Affinity DataIC50:  40nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2337(6-benzyl-1-(ethoxymethyl)-5-(propan-2-yl)-1,2,3,4-...)
Affinity DataIC50:  40nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Sapienza University of Rome

LigandPNGBDBM2337(6-benzyl-1-(ethoxymethyl)-5-(propan-2-yl)-1,2,3,4-...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration required to inhibit the HIV-1 reverse transcriptase activityMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2337(6-benzyl-1-(ethoxymethyl)-5-(propan-2-yl)-1,2,3,4-...)
Affinity DataIC50:  40nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2335(2-(butan-2-ylsulfanyl)-6-[(2,6-difluorophenyl)meth...)
Affinity DataIC50:  50nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2331(6-[(2,6-difluorophenyl)methyl]-2-(propan-2-ylsulfa...)
Affinity DataIC50:  50nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2334(6-[(2,6-difluorophenyl)methyl]-5-methyl-2-(propan-...)
Affinity DataIC50:  50nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2332(2-(butan-2-ylsulfanyl)-6-[(2,6-difluorophenyl)meth...)
Affinity DataIC50:  50nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2335(2-(butan-2-ylsulfanyl)-6-[(2,6-difluorophenyl)meth...)
Affinity DataIC50:  50nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2321(2-(cyclopentylsulfanyl)-6-[1-(2,6-difluorophenyl)e...)
Affinity DataIC50:  50nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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