Affinity DataIC50: 4.70nMAssay Description:Inhibition of DAG-activated human PKCbeta1 after 10 mins in presence of [32P]ATP by beta scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Inhibition of DAG-activated human PKCbeta2 after 10 mins in presence of [32P]ATP by beta scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of PKCbeta (unknown origin)More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
University College Cork
Curated by ChEMBL
University College Cork
Curated by ChEMBL
Affinity DataIC50: 6.80nMAssay Description:Inhibition of Wistar rat GSK-3beta using RRAAEELDSRAGS(P)PQL as substrate after 15 mins in presence of [gamma-32P]-ATP by scintillation counting meth...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant CLK1-GST expressed in Escherichia coli using GRSRSRSRSRSR as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of rat recombinant DYRK1A-GST expressed in Escherichia coli using KKISGRLSPIMTEQ as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta/[Tau protein] kinase(Sus scrofa)
University College Cork
Curated by ChEMBL
University College Cork
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of domestic porcine brain full length GSK-3alpha/beta using GS-1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant mouse CLK1 expressed in bacteria using GRSRSRSRSRSR as substrate in presence of [gamma-33P]ATP by radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of PKCalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:In vitro inhibition of human Cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of cytochrome P450 19A1 of human placental microsomes with [1beta,2beta-3H]testosteroneMore data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Inhibition of human recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:In vitro inhibition of human Cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:In vitro inhibition of human Cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:In vitro inhibition of human Cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibition of cytochrome P450 19A1 of human placental microsomes with [1beta,2beta-3H]testosteroneMore data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:In vitro inhibition of human Cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Inhibition of cytochrome P450 19A1 of human placental microsomes with [1beta,2beta-3H]testosteroneMore data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:In vitro inhibitiion of cytochrome P450 19A1 from human placental microsomes with 2.5 uM [1beta,2beta-3H]testosteroneMore data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Inhibition of cytochrome P450 19A1 of human placental microsomes with [1beta,2beta-3H]testosteroneMore data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of cytochrome P450 19A1 of human placental microsomes with [1beta,2beta-3H]testosteroneMore data for this Ligand-Target Pair
Affinity DataIC50: 71nMAssay Description:Inhibition of human recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:In vitro inhibition of human Cytochrome P450 19A1More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University College Cork
Curated by ChEMBL
University College Cork
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant full length human CDK9/cyclin T expressed in baculovirus infected Sf9 insect cells using YSPTSPSYSPTSPSYSPTSPSKKKK as subst...More data for this Ligand-Target Pair
Affinity DataIC50: 83nMAssay Description:Inhibition of PKCgamma (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 86nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 88nMAssay Description:Inhibition of human recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of cytochrome P450 19A1 of human placental microsomes with [1beta,2beta-3H]testosteroneMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University College Cork
Curated by ChEMBL
University College Cork
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of full length human CDK2/cyclin A using histone H1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of PKCepsilon (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of cytochrome P450 19A1 of human placental microsomes with [1beta,2beta-3H]testosteroneMore data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta/[Tau protein] kinase(Sus scrofa)
University College Cork
Curated by ChEMBL
University College Cork
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of domestic porcine brain full length GSK-3alpha/beta using GS-1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 136nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant mouse CLK1 expressed in bacteria using GRSRSRSRSRSR as substrate in presence of [gamma-33P]ATP by radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant human CK1 epsilon expressed in baculovirus infected Sf9 cells using RRKHAAIGSpAYSITA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of cytochrome P450 19A1 of human placental microsomes with [1beta,2beta-3H]testosteroneMore data for this Ligand-Target Pair
Affinity DataIC50: 171nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of human recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant human CK1 epsilon expressed in baculovirus infected Sf9 cells using RRKHAAIGSpAYSITA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 191nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of cytochrome P450 19A1 of human placental microsomes with [1beta,2beta-3H]testosteroneMore data for this Ligand-Target Pair