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Found 191 with Last Name = 'maresca' and Initial = 'p'
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265453((S)-2-(3-((S)-1-Carboxy-5-(3-(4-bromophenyl)ureido...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265381((S)-2-(3-((S)-1-Carboxy-5-(4-chlorobenzylamino)pen...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265471((S)-2-(3-((S)-1-Carboxy-5-(3-(4-fluorophenyl)ureid...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438224(CHEMBL2407759)
Affinity DataIC50:  4nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265454((S)-2-(3-((S)-1-Carboxy-5-(3-(4-chlorophenyl)ureid...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438335(CHEMBL2408610)
Affinity DataIC50:  9nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265474((S)-2-(3-((S)-1-Carboxy-5-(4-iodophenylsulfonamido...)
Affinity DataIC50:  10nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265783((S)-2-(3-((S)-1-Carboxy-5-(3-(4-iodophenyl)ureido)...)
Affinity DataIC50:  10nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438223(CHEMBL2407758)
Affinity DataIC50:  10nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265472((S)-2-(3-((S)-1-Carboxy-5-(3-phenylureido)pentyl)u...)
Affinity DataIC50:  12nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438224(CHEMBL2407759)
Affinity DataIC50:  12nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
LigandPNGBDBM50438223(CHEMBL2407758)
Affinity DataIC50:  13nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438329(CHEMBL2408616)
Affinity DataIC50:  14nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438335(CHEMBL2408610)
Affinity DataIC50:  15nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438322(CHEMBL2408612)
Affinity DataIC50:  17nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438331(CHEMBL2408615)
Affinity DataIC50:  17nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438219(CHEMBL2407761)
Affinity DataIC50:  18nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265473((9S,13S)-1-(3-iodophenyl)-3,11-dioxo-2,4,10,12-tet...)
Affinity DataIC50:  18nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438317(CHEMBL2408611)
Affinity DataIC50:  18nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438329(CHEMBL2408616)
Affinity DataIC50:  20nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103917(US8562945, 253)
Affinity DataIC50:  20nMAssay Description:Compounds were tested for their ability to inhibit separase enzyme.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103918(US8562945, 254)
Affinity DataIC50:  21nMAssay Description:Compounds were tested for their ability to inhibit separase enzyme.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265377((S)-2-(3-((S)-1-Carboxy-5-(4-iodobenzylamino)penty...)
Affinity DataIC50:  22nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103909(JNK3 inhibitor 6 | US8562945, 242)
Affinity DataIC50:  23nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50438222(CHEMBL2407757)
Affinity DataIC50:  23nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438317(CHEMBL2408611)
Affinity DataIC50:  28nMAssay Description:Inhibition of TAK1 in human TOV21G cells assessed as inhibition of JNK phosphorylationMore data for this Ligand-Target Pair
LigandPNGBDBM50438317(CHEMBL2408611)
Affinity DataIC50:  28nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
LigandPNGBDBM50438221(CHEMBL2407760)
Affinity DataIC50:  30nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438330(CHEMBL2408614)
Affinity DataIC50:  31nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265378((S)-2-(3-((S)-1-Carboxy-5-(2-iodobenzylamino)penty...)
Affinity DataIC50:  37nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103908(JNK3 inhibitor 5 | US8562945, 241)
Affinity DataIC50:  40nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103911(JNK3 inhibitor 8 | US8562945, 246)
Affinity DataIC50:  42nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438330(CHEMBL2408614)
Affinity DataIC50:  43nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265380((S)-2-(3-((S)-1-Carboxy-5-(4-bromobenzylamino)pent...)
Affinity DataIC50:  43nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438222(CHEMBL2407757)
Affinity DataIC50:  44nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438331(CHEMBL2408615)
Affinity DataIC50:  45nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438211(CHEMBL2407795)
Affinity DataIC50:  61nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438220(CHEMBL2407792)
Affinity DataIC50:  89nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438316(CHEMBL2408613)
Affinity DataIC50:  110nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438221(CHEMBL2407760)
Affinity DataIC50:  110nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438316(CHEMBL2408613)
Affinity DataIC50:  130nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438173(CHEMBL2407966)
Affinity DataIC50:  130nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103915(US8562945, 250)
Affinity DataIC50:  130nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103911(JNK3 inhibitor 8 | US8562945, 246)
Affinity DataIC50:  140nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50438325(CHEMBL2408617)
Affinity DataIC50:  150nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265489((S)-2-(3-((S)-1-Carboxy-5-(naphthalen-1-ylmethylam...)
Affinity DataIC50:  154nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438322(CHEMBL2408612)
Affinity DataIC50:  160nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438335(CHEMBL2408610)
Affinity DataIC50:  160nMAssay Description:Inhibition of aurora B kinase in human HT-29 cells assessed as inhibition of histone H3 S10 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103909(JNK3 inhibitor 6 | US8562945, 242)
Affinity DataIC50:  170nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103914(US8562945, 249)
Affinity DataIC50:  189nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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