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Found 337 with Last Name = 'pragani' and Initial = 'r'

Isocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
National Institutes of Health

BDBM228659((+)-2-(2-(1H-Benzo[d]imidazol-1-yl)-N-(3-fluorophe...)

IC50: 30nMAssay Description:The activity of IDH1 R132H and IDH1 R132C was measured in 384-well plates by coupling NADPH consumption to a diaphorase/resazurin-based detection sys...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567821(CHEMBL4875277)

IC50: 35nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567821(CHEMBL4875277)

IC50: 39nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567816(CHEMBL4851708)

IC50: 39nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567825(CHEMBL4861426)

IC50: 42nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567833(CHEMBL4868649)

IC50: 44nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567808(CHEMBL4860083)

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567815(CHEMBL4864243)

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567832(CHEMBL4878489)

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567815(CHEMBL4864243)

IC50: 46nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567828(CHEMBL4854924)

IC50: 47nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Galactokinase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50588170(CHEMBL5088290)

IC50: 48nMAssay Description:Inhibition of recombinant human GALK1 using galactose as substrate incubated for 1 hrs in the presence of ATP by Kinase-Glo reagent based luminescenc...More data for this Ligand-Target Pair

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Galactokinase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50588172(CHEMBL5073602)

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567819(CHEMBL4845768)

IC50: 48nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567820(CHEMBL4858156)

IC50: 49nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567809(CHEMBL4848154)

IC50: 49nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Galactokinase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50588172(CHEMBL5073602)

IC50: 49nMAssay Description:Inhibition of recombinant human GALK1 using galactose as substrate incubated for 1 hrs in the presence of ATP by Kinase-Glo reagent based luminescenc...More data for this Ligand-Target Pair

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Galactokinase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50588170(CHEMBL5088290)

IC50: 50nMAssay Description:Inhibition of recombinant human GALK1 using galactose as substrate incubated for 1 hrs in the presence of ATP by Kinase-Glo reagent based luminescenc...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567816(CHEMBL4851708)

IC50: 53nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567824(CHEMBL4879014)

IC50: 55nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567832(CHEMBL4878489)

IC50: 55nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567809(CHEMBL4848154)

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567830(CHEMBL4878829)

IC50: 56nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567823(CHEMBL4872718)

IC50: 56nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567808(CHEMBL4860083)

IC50: 58nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567820(CHEMBL4858156)

IC50: 60nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567827(CHEMBL4873139)

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567828(CHEMBL4854924)

IC50: 62nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
National Institutes of Health

BDBM228658(rac-ML309)

IC50: 62nMAssay Description:The activity of IDH1 R132H and IDH1 R132C was measured in 384-well plates by coupling NADPH consumption to a diaphorase/resazurin-based detection sys...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM363689(US10640534, Compound 176 | US10682352, Compound AG...)

IC50: 63nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567826(CHEMBL4872262)

IC50: 64nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567824(CHEMBL4879014)

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567782(CHEMBL4857251)

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM363689(US10640534, Compound 176 | US10682352, Compound AG...)

IC50: 65nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Galactokinase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50588173(CHEMBL5087686)

IC50: 68nMAssay Description:Inhibition of recombinant human GALK1 using galactose as substrate incubated for 1 hrs in the presence of ATP by Kinase-Glo reagent based luminescenc...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
National Institutes of Health

BDBM228659((+)-2-(2-(1H-Benzo[d]imidazol-1-yl)-N-(3-fluorophe...)

IC50: 68nMAssay Description:The activity of IDH1 R132H and IDH1 R132C was measured in 384-well plates by coupling NADPH consumption to a diaphorase/resazurin-based detection sys...More data for this Ligand-Target Pair

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Galactokinase(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50588173(CHEMBL5087686)

IC50: 71nMAssay Description:Inhibition of recombinant human GALK1 using galactose as substrate incubated for 1 hrs in the presence of ATP by Kinase-Glo reagent based luminescenc...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567817(CHEMBL4853810)

IC50: 72nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50503248(CHEMBL4448475)

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567834(CHEMBL4851468)

IC50: 75nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567834(CHEMBL4851468)

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567812(CHEMBL4864581)

IC50: 75nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567805(CHEMBL4867078)

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567819(CHEMBL4845768)

IC50: 78nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50503248(CHEMBL4448475)

IC50: 81nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567818(CHEMBL4863979)

IC50: 82nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567827(CHEMBL4873139)

IC50: 94nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567825(CHEMBL4861426)

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Isocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
National Institutes of Health

BDBM228658(rac-ML309)

IC50: 96nMAssay Description:The activity of IDH1 R132H and IDH1 R132C was measured in 384-well plates by coupling NADPH consumption to a diaphorase/resazurin-based detection sys...More data for this Ligand-Target Pair

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL

BDBM50567817(CHEMBL4853810)

IC50: 100nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair

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