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Found 2727 with Last Name = 'meyer' and Initial = 's'
TargetPlasma kallikrein(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514081(CHEMBL4471466)
Affinity DataKi:  0.0190nMAssay Description:Inhibition of human plasma kallikrein by Michaelis-menten analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514086(CHEMBL4524734)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human plasma kallikrein using S2302 as substrate after 10 mins by UV/Vis photometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108110(US8598206, Table 6, 19)
Affinity DataKi:  0.25nMAssay Description:Inhibition of human plasmin using tosyl-Gly-Pro-Lys-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108098(US8598206, Table 6, 7)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human plasma kallikrein using S2302 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514081(CHEMBL4471466)
Affinity DataKi:  0.460nMAssay Description:Inhibition of activated protein kinase C (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514082(CHEMBL4462811)
Affinity DataKi:  0.480nMAssay Description:Inhibition of human plasmin using tosyl-Gly-Pro-Lys-pNA as substrate after 10 mins by UV/Vis photometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514082(CHEMBL4462811)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human plasma kallikrein using S2302 as substrate after 10 mins by UV/Vis photometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108098(US8598206, Table 6, 7)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human plasmin using tosyl-Gly-Pro-Lys-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514086(CHEMBL4524734)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human plasmin using tosyl-Gly-Pro-Lys-pNA as substrate after 10 mins by UV/Vis photometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108110(US8598206, Table 6, 19)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human plasma kallikrein using S2302 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM29388(Exanta | Melagatran | US11584714, Compound 999)
Affinity DataKi:  2nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
TargetPlasminogen(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514081(CHEMBL4471466)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human plasmin by Michaelis-menten analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50119168((2R,3R,4S,5R)-2-(6-Amino-2-hex-1-ynyl-purin-9-yl)-...)
Affinity DataKi:  2.20nMAssay Description:Receptor binding affinity for the adenosine A2A receptor was determined using [3H]-ZM-241,385 as a radioligand in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108101(US8598206, Table 6, 10)
Affinity DataKi:  3nMAssay Description:Inhibition of human plasmin using tosyl-Gly-Pro-Lys-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50380629(CHEMBL2016877)
Affinity DataKi:  3.10nMAssay Description:Inhibition of human plasmin assessed as reduction in proteolysis activity in presence of fibrinogen after 90 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514066(CHEMBL4589217)
Affinity DataKi:  3.30nMAssay Description:Inhibition of human plasmin assessed as reduction in proteolysis activity in presence of fibrinogen after 90 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108101(US8598206, Table 6, 10)
Affinity DataKi:  7.5nMAssay Description:Inhibition of human plasma kallikrein using S2302 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50119153((2R,3R,4S,5R)-2-[6-Amino-2-((E)-hex-1-enyl)-purin-...)
Affinity DataKi:  14nMAssay Description:Receptor binding affinity for the adenosine A2A receptor was determined using [3H]-ZM-241,385 as a radioligand in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394646(CHEMBL2164608)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]PGE2 from human EP3R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514081(CHEMBL4471466)
Affinity DataKi:  18nMAssay Description:Inhibition of human factor 11aMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50119134((2R,3R,4S,5R)-2-(6-Amino-2-{N'-[1-cyclohexyl-meth-...)
Affinity DataKi:  20nMAssay Description:Binding affinity for Adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394647(CHEMBL2164610)
Affinity DataKi:  23.4nMAssay Description:Displacement of [3H]PGE2 from human EP3R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394645(CHEMBL2164609)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]PGE2 from human EP3R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514080(CHEMBL4520324)
Affinity DataKi:  28nMAssay Description:Inhibition of urokinase-type plasminogen activator (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514080(CHEMBL4520324)
Affinity DataKi:  36nMAssay Description:Inhibition of plasmin (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50110015(CHEMBL158936 | N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AM...)
Affinity DataKi:  36nMAssay Description:Inhibition of urokinase-type plasminogen activator (unknown origin)More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514081(CHEMBL4471466)
Affinity DataKi:  45nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50119165(1-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydrox...)
Affinity DataKi:  50nMAssay Description:Receptor binding affinity for the adenosine A2A receptor was determined using [3H]-ZM-241,385 as a radioligand in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50119131(1-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydrox...)
Affinity DataKi:  60nMAssay Description:Receptor binding affinity for the adenosine A2A receptor was determined using [3H]-ZM-241,385 as a radioligand in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50119142(1-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydrox...)
Affinity DataKi:  60nMAssay Description:Receptor binding affinity for the adenosine A2A receptor was determined using [3H]-ZM-241,385 as a radioligand in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50119152(1-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydrox...)
Affinity DataKi:  60nMAssay Description:Receptor binding affinity for the adenosine A2A receptor was determined using [3H]-ZM-241,385 as a radioligand in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50119134((2R,3R,4S,5R)-2-(6-Amino-2-{N'-[1-cyclohexyl-meth-...)
Affinity DataKi:  66nMAssay Description:Receptor binding affinity for the adenosine A2A receptor was determined using [3H]-ZM-241,385 as a radioligand in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50119165(1-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydrox...)
Affinity DataKi:  120nMAssay Description:Receptor binding affinity for the adenosine A2A receptor were determined using [3H]-ZM-241,385 as a radioligand in pigMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108110(US8598206, Table 6, 19)
Affinity DataKi: >130nMAssay Description:Inhibition of human Complement C1s subcomponent using Val-Ser-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108110(US8598206, Table 6, 19)
Affinity DataKi: >130nMAssay Description:Inhibition of human factor 11a using H-D-Lys(Cbo)-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108110(US8598206, Table 6, 19)
Affinity DataKi: >130nMAssay Description:Inhibition of human activated protein kinase C using H-D-Lys(Cbo)-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108110(US8598206, Table 6, 19)
Affinity DataKi: >130nMAssay Description:Inhibition of human tissue-type plasminogen activator using Mes-d-Cha- Gly-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108110(US8598206, Table 6, 19)
Affinity DataKi: >130nMAssay Description:Inhibition of human Complement C1r subcomponent using Val-Ser-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108110(US8598206, Table 6, 19)
Affinity DataKi: >130nMAssay Description:Inhibition of human factor 2a using Mes-d-Cha-Gly-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108110(US8598206, Table 6, 19)
Affinity DataKi: >130nMAssay Description:Inhibition of human factor 10a using MeOCO-d-Cha-Gly-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108110(US8598206, Table 6, 19)
Affinity DataKi: >130nMAssay Description:Inhibition of human factor 12a using CHA-Gly-Arg- pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394644(CHEMBL2164612)
Affinity DataKi:  135nMAssay Description:Displacement of [3H]PGE2 from human EP3R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50119167(1-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydrox...)
Affinity DataKi:  140nMAssay Description:Receptor binding affinity for the adenosine A2A receptor was determined using [3H]-ZM-241,385 as a radioligand in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50272222(CHEMBL4128356)
Affinity DataKi:  140nMAssay Description:Inhibition of human plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50119144((2R,3R,4S,5R)-2-{6-Amino-2-[4-(4-methoxy-phenyl)-p...)
Affinity DataKi:  190nMAssay Description:Receptor binding affinity for the adenosine A2A receptor was determined using [3H]-ZM-241,385 as a radioligand in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50119149((2R,3R,4S,5R)-2-[6-Amino-2-(4-p-tolyl-pyrazol-1-yl...)
Affinity DataKi:  190nMAssay Description:Receptor binding affinity for the adenosine A2A receptor was determined using [3H]-ZM-241,385 as a radioligand in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50119161(1-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydrox...)
Affinity DataKi:  210nMAssay Description:Receptor binding affinity for the adenosine A2A receptor was determined using [3H]-ZM-241,385 as a radioligand in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394648(CHEMBL2164611)
Affinity DataKi:  219nMAssay Description:Displacement of [3H]PGE2 from human EP3R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50119141((2R,3R,4S,5R)-2-[6-Amino-2-(1-cyclohexylmethyl-1H-...)
Affinity DataKi:  220nMAssay Description:Receptor binding affinity for the adenosine A2A receptor was determined using [3H]-ZM-241,385 as a radioligand in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50119132(1-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydrox...)
Affinity DataKi:  290nMAssay Description:Receptor binding affinity for the adenosine A2A receptor was determined using [3H]-ZM-241,385 as a radioligand in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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