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Found 473 with Last Name = 'neidle' and Initial = 's'
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386447(CHEMBL2047701)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386442(CHEMBL2047694)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386435(CHEMBL2047702)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50339190(CHEMBL443683 | telomestatin)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human Telomerase activity in cell free system by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386453(CHEMBL2047540)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386441(CHEMBL2047692)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386444(CHEMBL2047696)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290670(5-Mercapto-5-[(S)-3-methyl-1-((S)-1-methylcarbamoy...)
Affinity DataIC50:  1nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386443(CHEMBL2047695)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386434(CHEMBL2047699)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386440(CHEMBL2047691)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386448(CHEMBL2047703)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386457(CHEMBL2047541)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386450(CHEMBL2047684)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386439(CHEMBL2047690)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290675(5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-mercapto...)
Affinity DataIC50:  3nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290671((S)-4-(2,5-Dioxo-pyrrolidin-1-yl)-2-mercapto-N-[(R...)
Affinity DataIC50:  3nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386445(CHEMBL2047698)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386449(CHEMBL2047704)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386437(CHEMBL2047688)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386446(CHEMBL2047700)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386452(CHEMBL2047680)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290671((S)-4-(2,5-Dioxo-pyrrolidin-1-yl)-2-mercapto-N-[(R...)
Affinity DataIC50:  5nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386472(CHEMBL2047681)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290668(2-Mercapto-5-methanesulfonylamino-pentanoic acid [...)
Affinity DataIC50:  6nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386438(CHEMBL2047689)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290671((S)-4-(2,5-Dioxo-pyrrolidin-1-yl)-2-mercapto-N-[(R...)
Affinity DataIC50:  9nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290671((S)-4-(2,5-Dioxo-pyrrolidin-1-yl)-2-mercapto-N-[(R...)
Affinity DataIC50:  10nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386436(CHEMBL2047687)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290670(5-Mercapto-5-[(S)-3-methyl-1-((S)-1-methylcarbamoy...)
Affinity DataIC50:  14nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386462(CHEMBL2047670)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290669((S)-2-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-m...)
Affinity DataIC50:  15nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290667(5-Mercapto-5-[(S)-3-methyl-1-((S)-1-methylcarbamoy...)
Affinity DataIC50:  15nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50117090((E,E)-Psammaplin A | 3-(3-Bromo-4-hydroxy-phenyl)-...)
Affinity DataIC50:  18.6nMAssay Description:Inhibition of semi-purified DNMT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290668(2-Mercapto-5-methanesulfonylamino-pentanoic acid [...)
Affinity DataIC50:  19nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290678((S)-2-(2-Mercapto-3-phenyl-propionylamino)-4-methy...)
Affinity DataIC50:  20nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290675(5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-mercapto...)
Affinity DataIC50:  25nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386431(CHEMBL2047669)
Affinity DataIC50:  27nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290673(6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-mercapto...)
Affinity DataIC50:  30nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290677((S)-2-(2-Mercapto-3-methyl-butyrylamino)-4-methyl-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290674((R)-4-(2,5-Dioxo-pyrrolidin-1-yl)-2-mercapto-N-[(R...)
Affinity DataIC50:  30nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290674((R)-4-(2,5-Dioxo-pyrrolidin-1-yl)-2-mercapto-N-[(R...)
Affinity DataIC50:  30nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290669((S)-2-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-m...)
Affinity DataIC50:  31nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290667(5-Mercapto-5-[(S)-3-methyl-1-((S)-1-methylcarbamoy...)
Affinity DataIC50:  32nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290678((S)-2-(2-Mercapto-3-phenyl-propionylamino)-4-methy...)
Affinity DataIC50:  40nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386456(CHEMBL2047539)
Affinity DataIC50:  43nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290671((S)-4-(2,5-Dioxo-pyrrolidin-1-yl)-2-mercapto-N-[(R...)
Affinity DataIC50:  45nMAssay Description:Inhibition of matrix metalloproteinase-3, MMP-3More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50117090((E,E)-Psammaplin A | 3-(3-Bromo-4-hydroxy-phenyl)-...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290672((S)-2-(2-Mercapto-acetylamino)-4-methyl-pentanoic ...)
Affinity DataIC50:  50nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
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