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Found 131 with Last Name = 'mckeown' and Initial = 'sc'
TargetCytochrome P450 2C19(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411560(CHEMBL240436)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411560(CHEMBL240436)
Affinity DataIC50:  4.17E+3nMAssay Description:Inhibition of FP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411560(CHEMBL240436)
Affinity DataIC50:  6.31E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50191163(1-(2-(benzyloxy)-5-bromobenzyl)-5-methyl-1H-pyrazo...)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of CYP450 1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at alpha-1A adrenergic receptor (unknown origin) expressed in CHOK1 cells after 15 mins by calcium flux/FLIPR assay in presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at CB1 receptor (unknown origin) expressed in rat CHEM-1 cells after 15 mins by calcium flux/FLIPR assay in presence of CP55940More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at 5HT2B receptor (unknown origin) expressed in CHOK1 cells after 15 mins by calcium flux/FLIPR assay in presence of BW723C86More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at 5HT2A receptor (unknown origin) expressed in CHOK1 cells after 15 mins by calcium flux/FLIPR assay in presence of 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at 5HT1A receptor (unknown origin) expressed in HeLa cells after 15 mins by calcium flux/FLIPR assay in presence of R-(+)-8-OH-DP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at alpha-2A adrenergic receptor (unknown origin) expressed in CHOK1 cells after 15 mins by calcium flux/FLIPR assay in presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at thromboxane A2 receptor (unknown origin) expressed in HEK293-EBNA cells after 15 mins by calcium flux/FLIPR assay in presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at muscarinic acetylcholine receptor M2 (unknown origin) expressed in CHOK1 cells after 15 mins by calcium flux/FLIPR assay in pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at D1A receptor (unknown origin) expressed in CHOK1 cells after 5 mins by HTRF cAMP immunoassay in presence of cAMP/SKF38393More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411560(CHEMBL240436)
Affinity DataIC50:  3.16E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50191163(1-(2-(benzyloxy)-5-bromobenzyl)-5-methyl-1H-pyrazo...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP450 2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50191163(1-(2-(benzyloxy)-5-bromobenzyl)-5-methyl-1H-pyrazo...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP450 3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50191163(1-(2-(benzyloxy)-5-bromobenzyl)-5-methyl-1H-pyrazo...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP450 2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50191163(1-(2-(benzyloxy)-5-bromobenzyl)-5-methyl-1H-pyrazo...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411560(CHEMBL240436)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22496(3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propan...)
Affinity DataEC50:  79nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22497(2-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)cyclop...)
Affinity DataEC50:  50nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22498(3-(3-{[(3-phenoxyphenyl)methyl]amino}phenyl)propan...)
Affinity DataEC50:  398nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22499(4-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)butano...)
Affinity DataEC50:  3.16E+3nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22500(2-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propan...)
Affinity DataEC50:  1.66E+4nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22501(2-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)acetic...)
Affinity DataEC50:  3.98E+3nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22502(3-(4-{[(4-phenylphenyl)methyl]amino}phenyl)propano...)
Affinity DataEC50:  251nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22503(2-(4-{[(4-phenylphenyl)methyl]amino}phenyl)cyclopr...)
Affinity DataEC50:  40nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22504(3-(3-{[(4-phenylphenyl)methyl]amino}phenyl)propano...)
Affinity DataEC50:  501nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22505(4-(4-{[(4-phenylphenyl)methyl]amino}phenyl)butanoi...)
Affinity DataEC50:  1.59E+3nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22506(2-(4-{[(4-phenylphenyl)methyl]amino}phenyl)propano...)
Affinity DataEC50: >3.16E+4nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22507(2-(4-{[(4-phenylphenyl)methyl]amino}phenyl)acetic ...)
Affinity DataEC50:  1.23E+4nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22508(3-(4-{[(3,4-dichlorophenyl)methyl]amino}phenyl)pro...)
Affinity DataEC50:  251nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22509(3-{4-[(naphthalen-2-ylmethyl)amino]phenyl}propanoi...)
Affinity DataEC50:  794nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22510(3-(4-{[(3-bromophenyl)methyl]amino}phenyl)propanoi...)
Affinity DataEC50:  794nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22511(3-(4-{[(5-chlorothiophen-2-yl)methyl]amino}phenyl)...)
Affinity DataEC50:  2.00E+3nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22512(3-[4-({[4-(trifluoromethyl)phenyl]methyl}amino)phe...)
Affinity DataEC50:  2.00E+3nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22513(3-(4-{[(2-chlorophenyl)methyl]amino}phenyl)propano...)
Affinity DataEC50:  3.98E+3nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22514(3-(4-{[(4-methylphenyl)methyl]amino}phenyl)propano...)
Affinity DataEC50:  3.98E+3nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22515(3-(4-{[(3-fluorophenyl)methyl]amino}phenyl)propano...)
Affinity DataEC50:  5.01E+3nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22516(3-[4-({[2-chloro-5-(trifluoromethyl)pyridin-3-yl]m...)
Affinity DataEC50:  5.01E+3nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22517(3-[4-(benzylamino)phenyl]propanoic acid | carboxyl...)
Affinity DataEC50:  7.94E+3nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22518(3-{4-[(pyridin-3-ylmethyl)amino]phenyl}propanoic a...)
Affinity DataEC50: >3.16E+4nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22519(3-{4-[({4-[(dimethylamino)methyl]phenyl}methyl)ami...)
Affinity DataEC50: >3.16E+4nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22520(3-{4-[(2H-1,3-benzodioxol-5-ylmethyl)amino]phenyl}...)
Affinity DataEC50: >3.16E+4nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22521(4-({[4-(2-carboxyethyl)phenyl]amino}methyl)benzoic...)
Affinity DataEC50: >3.16E+4nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22522(3-(4-{[(4-hydroxyphenyl)methyl]amino}phenyl)propan...)
Affinity DataEC50: >3.16E+4nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22523(3-(4-{[(4-cyanophenyl)methyl]amino}phenyl)propanoi...)
Affinity DataEC50: >3.16E+4nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22524(3-(4-{[(4-methoxyphenyl)methyl]amino}phenyl)propan...)
Affinity DataEC50:  1.26E+3nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22525(3-(4-{[(3-carbamoylphenyl)methyl]amino}phenyl)prop...)
Affinity DataEC50: >3.16E+4nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM22526(3-{4-[(1H-imidazol-2-ylmethyl)amino]phenyl}propano...)
Affinity DataEC50: >3.16E+4nMT: 2°CAssay Description:The reporter assay for the stable hGPR40-Gal4-Elk1/5xGal4-luc+-expressing CHO cells was first carried out in the serum-free medium in the presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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