Affinity DataIC50: 0.5nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 0.590nMAssay Description:Inhibition of PKB in human U87MG cells assessed as GSK3beta phosphorylation by ELISAMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 0.660nMAssay Description:Inhibition of PKB in human U87MG cells assessed as GSK3beta phosphorylation by ELISAMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PKB in human PC3M cells assessed as GSK3beta phosphorylation by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of PKB in human PC3M cells assessed as GSK3beta phosphorylation by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of PKBbeta recombinant by radiometric filter binding assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of PKB in human PC3M cells assessed as GSK3beta phosphorylation by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of PKB in human PC3M cells assessed as GSK3beta phosphorylation by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of PKBbeta recombinant by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of PKBbeta recombinant by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of PKB in human U87MG cells assessed as GSK3beta phosphorylation by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of PKBbeta recombinant by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of PKBbeta recombinant by radiometric filter binding assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 7.20nMAssay Description:Inhibition of PKB in human U87MG cells assessed as GSK3beta phosphorylation by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of PKBbeta recombinant by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.5nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Astex Pharmaceuticals
Curated by ChEMBL
Astex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Displacement of 5'-TAMRA-labelled NRF2 peptide from human N-terminal His6-tagged KEAP1 Kelch domain (321 to 609 residues) expressed in baculovirus in...More data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Institute of Cancer Research
US Patent
The Institute of Cancer Research
US Patent
Affinity DataIC50: <10nMpH: 7.5 T: 2°CAssay Description:In a final reaction volume of 25 ul, ROCK-II (h) (5-10 mU) is incubated with 50 mM Tris pH 7.5, 0.1 mM EGTA, 30 uM KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK (...More data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of PKBbeta recombinant by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMpH: 7.2 T: 2°CAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair