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Found 1768 with Last Name = 'little' and Initial = 'tl'
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065588(CHEMBL96803 | [(S)-1-((S)-1-{(S)-1-Formyl-2-[(isox...)
Affinity DataKi:  5nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065603(CHEMBL96185 | {(S)-1-[(S)-1-((S)-1-Formyl-3-methan...)
Affinity DataKi:  5nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065598(CHEMBL419332 | {(S)-1-[(S)-1-((S)-3-Dimethylcarbam...)
Affinity DataKi:  5nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065590(((S)-1-{(S)-1-[(S)-1-(Acetylamino-methyl)-2-oxo-et...)
Affinity DataKi:  6nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065586(((S)-3-Methyl-1-{(S)-1-[(S)-2-oxo-1-(propionylamin...)
Affinity DataKi:  7nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065595(((S)-1-{(S)-1-[(S)-2-(3,3-Dimethyl-ureido)-1-formy...)
Affinity DataKi:  10nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065599(CHEMBL94652 | {(S)-1-[(S)-1-((S)-2-Benzoylamino-1-...)
Affinity DataKi:  12nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065601(CHEMBL95031 | {(S)-1-[(S)-1-((S)-1-Formyl-2-isobut...)
Affinity DataKi:  18nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065590(((S)-1-{(S)-1-[(S)-1-(Acetylamino-methyl)-2-oxo-et...)
Affinity DataKi:  36nMAssay Description:Binding affinity of the compound was measured against HRV-16 3C proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065591(((S)-1-{(S)-1-[(S)-1-Formyl-3-(trityl-carbamoyl)-p...)
Affinity DataKi:  40nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065596(((S)-1-{(S)-1-[(S)-1-Formyl-2-(2-oxo-pyrrolidin-1-...)
Affinity DataKi:  52nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065594(((S)-1-{(S)-1-[(S)-1-(tert-Butoxycarbonylamino-met...)
Affinity DataKi:  66nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065590(((S)-1-{(S)-1-[(S)-1-(Acetylamino-methyl)-2-oxo-et...)
Affinity DataKi:  69nMAssay Description:Binding affinity of the compound was measured against HRV-2 3C proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065589(CHEMBL95120 | {(S)-1-[(S)-1-((S)-1-Formylaminometh...)
Affinity DataKi:  73nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065597(((S)-1-{(S)-1-[(S)-1-(Methoxycarbonylamino-methyl)...)
Affinity DataKi:  132nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065593(((S)-1-{(S)-1-[(S)-1-Formyl-2-(2,2,2-trifluoro-ace...)
Affinity DataKi:  146nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065590(((S)-1-{(S)-1-[(S)-1-(Acetylamino-methyl)-2-oxo-et...)
Affinity DataKi:  160nMAssay Description:Binding affinity of the compound was measured against HRV-89 3C proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065587(CHEMBL97090 | {(S)-1-[(S)-1-((S)-3-Cyano-1-formyl-...)
Affinity DataKi:  190nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065600(((S)-1-{(S)-1-[(S)-2-(Acetyl-methyl-amino)-1-formy...)
Affinity DataKi:  469nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM604241(Preparation of (2R,4S)-2-(((S)-1-((4-carbamimidoyl...)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay protocol is carried out as follows. Test compounds are serially diluted in DMSO and then 100 nL of each dilution is transferred to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM604242(Preparation of ethyl 3-((2R,4S)-2-(((S)-1-((4-carb...)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay protocol is carried out as follows. Test compounds are serially diluted in DMSO and then 100 nL of each dilution is transferred to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM604243(Preparation of 3-((2R,4S)-2-(((S)-1-((4-carbamimid...)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay protocol is carried out as follows. Test compounds are serially diluted in DMSO and then 100 nL of each dilution is transferred to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM604244(US11661418, Compound I-15)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay protocol is carried out as follows. Test compounds are serially diluted in DMSO and then 100 nL of each dilution is transferred to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM604245(US11661418, Compound I-16)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay protocol is carried out as follows. Test compounds are serially diluted in DMSO and then 100 nL of each dilution is transferred to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM604246(Preparation of (S)—N-(4-carbamimidoylbenzyl)-1-((2...)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay protocol is carried out as follows. Test compounds are serially diluted in DMSO and then 100 nL of each dilution is transferred to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM604249(Preparation of (2R,4S)—N—((S)-1-((4-carbamimidoylb...)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay protocol is carried out as follows. Test compounds are serially diluted in DMSO and then 100 nL of each dilution is transferred to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM604250(Preparation of (2R,4S)-4-(3-(1H-pyrazol-1-yl)pheny...)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay protocol is carried out as follows. Test compounds are serially diluted in DMSO and then 100 nL of each dilution is transferred to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM604251(Preparation of (2R,4S)—N—((S)-1-(((5-((Z)—N-hydrox...)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay protocol is carried out as follows. Test compounds are serially diluted in DMSO and then 100 nL of each dilution is transferred to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM595061(US11584714, Compound 1089)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM595062(US11584714, Compound 1090)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Mouse)
Omeros

US Patent
LigandPNGBDBM595062(US11584714, Compound 1090)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Mouse)
Omeros

US Patent
LigandPNGBDBM595063(US11584714, Compound 1091)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM595064(US11584714, Compound 1092)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Mouse)
Omeros

US Patent
LigandPNGBDBM595064(US11584714, Compound 1092)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetthrombin(Homo sapiens (Human))
Omeros

US Patent
LigandPNGBDBM595064(US11584714, Compound 1092)
Affinity DataKi: <500nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM595065(US11584714, Compound 1093)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetthrombin(Homo sapiens (Human))
Omeros

US Patent
LigandPNGBDBM595401(US11584714, Compound 1489)
Affinity DataKi: <500nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM595402(US11584714, Compound 1490)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetthrombin(Homo sapiens (Human))
Omeros

US Patent
LigandPNGBDBM595402(US11584714, Compound 1490)
Affinity DataKi: <500nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Mouse)
Omeros

US Patent
LigandPNGBDBM595403(US11584714, Compound 1491)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetthrombin(Homo sapiens (Human))
Omeros

US Patent
LigandPNGBDBM595403(US11584714, Compound 1491)
Affinity DataKi: <500nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM595404(US11584714, Compound 1492)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Mouse)
Omeros

US Patent
LigandPNGBDBM595404(US11584714, Compound 1492)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetthrombin(Homo sapiens (Human))
Omeros

US Patent
LigandPNGBDBM595404(US11584714, Compound 1492)
Affinity DataKi: <500nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM595406(US11584714, Compound 1494)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Mouse)
Omeros

US Patent
LigandPNGBDBM595406(US11584714, Compound 1494)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM595408(US11584714, Compound 1496)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM595409(US11584714, Compound 1497)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM604240(Preparation of (2R,4S)—N—((S)-1-((4-((Z)—N′-...)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay protocol is carried out as follows. Test compounds are serially diluted in DMSO and then 100 nL of each dilution is transferred to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM595389(US11584714, Compound 1477)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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