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Found 125 with Last Name = 'chen' and Initial = 'tm'
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035489((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-sulfonyl)-b...)
Affinity DataKi:  2nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035500((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataKi:  3nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035488((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataKi:  7nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 100 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035498((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  12nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035492((S)-1-{(S)-3-Methyl-2-[4-(2-methyl-4-morpholin-4-y...)
Affinity DataKi:  19nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50115808(CHEMBL61616 | Dimethyl-[2-(pyridin-3-yloxy)-ethyl]...)
Affinity DataKi:  21nMAssay Description:Affinity to alpha-4-beta-2 AChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035494(CHEMBL429359 | N-{(S)-2-Methyl-1-[(S)-2-(3,3,4,4,4...)
Affinity DataKi:  21nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035485((S)-1-((S)-3-Methyl-2-{4-[4-(morpholine-4-carbonyl...)
Affinity DataKi:  24nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035495((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  25nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 50 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50115825(CHEMBL60792 | Ethyl-methyl-pyridin-3-ylmethyl-amin...)
Affinity DataKi:  28nMAssay Description:Affinity to alpha-4-beta-2 AChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035487(CHEMBL140639 | N-{(S)-2-Methyl-1-[(S)-2-(3,3,4,4,4...)
Affinity DataKi:  28nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035502((S)-1-[(S)-3-Methyl-2-(3-pyridin-3-yl-propionylami...)
Affinity DataKi:  29nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50120586(CHEMBL112221 | Methyl-[2-(pyridin-3-yloxy)-ethyl]-...)
Affinity DataKi:  35nMAssay Description:Affinity to alpha-4-beta-2 AChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035505(CHEMBL140763 | N-{(S)-2-Methyl-1-[(S)-2-(3,3,4,4,4...)
Affinity DataKi:  39nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035497(CHEMBL141423 | Morpholine-4-carboxylic acid (4-{(S...)
Affinity DataKi:  43nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 50 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035486((S)-1-{(S)-3-Methyl-2-[3-methyl-2-(morpholine-4-ca...)
Affinity DataKi:  44nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035501((S)-1-{(S)-3-Methyl-2-[(tetrahydro-pyran-4-carbony...)
Affinity DataKi:  59nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 50 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035499((S)-1-[(S)-3-Methyl-2-(2-morpholin-4-yl-acetylamin...)
Affinity DataKi:  60nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 50 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035493((S)-1-[(S)-3-Methyl-2-(3-morpholin-4-yl-3-oxo-prop...)
Affinity DataKi:  70nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 25 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035504((S)-1-((S)-2-Benzoylamino-3-methyl-butyryl)-pyrrol...)
Affinity DataKi:  70nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50138489(CHEMBL54860 | Methyl-(4-pyridin-3-yl-but-3-ynyl)-a...)
Affinity DataKi:  113nMAssay Description:Affinity to alpha-4-beta-2 AChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035490(CHEMBL141517 | Morpholine-4-carboxylic acid {(S)-2...)
Affinity DataKi:  170nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 50 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035496((S)-1-{(S)-2-[(Furan-2-carbonyl)-amino]-3-methyl-b...)
Affinity DataKi:  190nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 45 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035491(CHEMBL59091 | Morpholine-4-carboxylic acid {(S)-2-...)
Affinity DataKi:  195nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Peking University

Curated by ChEMBL
LigandPNGBDBM50061567(1,1-Dimethyl-4-phenyl-piperazin-1-ium | CHEMBL1347...)
Affinity DataKi:  250nMAssay Description:Binding affinity towards nicotinic receptor in rat brain using [3H]cytisine ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035506((S)-1-[(S)-2-(3,3-Dimethyl-ureido)-3-methyl-butyry...)
Affinity DataKi:  261nMAssay Description:In vitro inhibitory activity against human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50138494(CHEMBL150893 | Dimethyl-(4-pyridin-3-yl-but-3-ynyl...)
Affinity DataKi:  510nMAssay Description:Affinity to alpha-4-beta-2 AChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50119559(CHEMBL331904 | Dimethyl-pyridin-3-ylmethyl-amine |...)
Affinity DataKi:  540nMAssay Description:Affinity to alpha-4-beta-2 AChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035503((S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2...)
Affinity DataKi:  1.20E+3nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50138487(CHEMBL150948 | Ethyl-methyl-(4-pyridin-3-yl-but-3-...)
Affinity DataKi:  1.77E+3nMAssay Description:Affinity to alpha-4-beta-2 AChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50138486(CHEMBL357101 | Methyl-pyridin-3-ylmethyl-amine | N...)
Affinity DataKi: >1.00E+4nMAssay Description:Affinity to alpha-4-beta-2 AChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50259656(CHEMBL4089402)
Affinity DataIC50:  0.000200nMAssay Description:Dissociation constant against galectin-3 using competitive fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50259645(CHEMBL4070336)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVYaminoluciferin as substrate after 2 hrs by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of alpha-4-beta-2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50259657(CHEMBL4068221)
Affinity DataIC50:  2nMAssay Description:Dissociation constant against galectin-3 using competitive fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50259647(CHEMBL4100727)
Affinity DataIC50:  2nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVYaminoluciferin as substrate after 2 hrs by fluorescence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290298((1-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimet...)
Affinity DataIC50:  2.10nMAssay Description:Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-K receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290306((1-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimet...)
Affinity DataIC50:  2.20nMAssay Description:Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50290302(1-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimeth...)
Affinity DataIC50:  2.5nMAssay Description:Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50290313((1'-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trime...)
Affinity DataIC50:  2.5nMAssay Description:Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50259659(CHEMBL4076838)
Affinity DataIC50:  3nMAssay Description:Dissociation constant against galectin-3 using competitive fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290303((1-{2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy...)
Affinity DataIC50:  3.10nMAssay Description:Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50290297(1-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimeth...)
Affinity DataIC50:  3.10nMAssay Description:Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-K receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290312((1-{2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy...)
Affinity DataIC50:  3.60nMAssay Description:Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50290306((1-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimet...)
Affinity DataIC50:  3.90nMAssay Description:Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Affinity DataIC50:  4nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVYaminoluciferin as substrate after 2 hrs by fluorescence ...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50259642(CHEMBL4077037)
Affinity DataIC50:  4nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVYaminoluciferin as substrate after 2 hrs by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50290307(1'-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimet...)
Affinity DataIC50:  4nMAssay Description:Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50290298((1-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimet...)
Affinity DataIC50:  4.30nMAssay Description:Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50290303((1-{2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy...)
Affinity DataIC50:  4.5nMAssay Description:Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPMore data for this Ligand-Target Pair
In DepthDetails Article
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