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TargetAndrogen receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataKi:  78nMAssay Description:Displacement of [3H]-mibolerone from GST-tagged human AR-LBD expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50529647(CHEMBL4584527 | US10806720, Compound 17 | US112305...)
Affinity DataKi:  267nMAssay Description:Displacement of [3H]-mibolerone from GST-tagged human AR-LBD expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50425732(ENZALUTAMIDE | US10053433, FC 4.129 | US10806720, ...)
Affinity DataKi:  3.64E+3nMAssay Description:Displacement of [3H]-mibolerone from GST-tagged human AR-LBD expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239948(CHEMBL4071326 | US9850225, Example 1166)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human PD-1/PDL1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) expressed in baculovirus expression system using poly (Glu-Tyr) 4:1 as substrate incubated for...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) expressed in baculovirus expression system using poly (Glu-Tyr) 4:1 as substrate incubated for...More data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239946(CHEMBL4084368)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human PD-1/PDL1 by HTRF assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM109086(US10793535, Cmpd ID 727 | US8604016, 670 | US99382...)
Affinity DataIC50:  5nMAssay Description:Inhibition of GAC (unknown origin)More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50574392(CHEMBL4849357)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human GLS1 expressed in Escherichia coli strain BL21 (DE3) preincubated for 10 mins before glutamine addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543578(CHEMBL4644718)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50559447(CHEMBL4795985)
Affinity DataIC50:  7nMAssay Description:Inhibition of PD-1/PDL1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50566568(CHEMBL4850947)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 135 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50566577(CHEMBL4847490)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 135 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50559448(CHEMBL4784449)
Affinity DataIC50:  9nMAssay Description:Inhibition of PD-1/PDL1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50566552(CHEMBL4851240)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 135 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543578(CHEMBL4644718)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50230972(CHEMBL4069394)
Affinity DataIC50:  11nMAssay Description:Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50566579(CHEMBL4877207)
Affinity DataIC50:  11nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 135 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50566557(CHEMBL4855102)
Affinity DataIC50:  13nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 135 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543583(CHEMBL4639712)
Affinity DataIC50:  14nMAssay Description:Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50566567(CHEMBL4863242)
Affinity DataIC50:  14nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 135 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50566570(CHEMBL4865166)
Affinity DataIC50:  15nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 135 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543578(CHEMBL4644718)
Affinity DataIC50:  16nMAssay Description:Inhibition of LYN (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Affinity DataIC50:  16nMAssay Description:Inhibition of SRC (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50566574(CHEMBL4857610)
Affinity DataIC50:  16nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 135 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543578(CHEMBL4644718)
Affinity DataIC50:  17nMAssay Description:Inhibition of c-Kit (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human PD-1/PDL1 by HTRF assayMore data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50566580(CHEMBL4855372)
Affinity DataIC50:  19nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 135 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50566565(CHEMBL4871618)
Affinity DataIC50:  20nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 135 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM109086(US10793535, Cmpd ID 727 | US8604016, 670 | US99382...)
Affinity DataIC50:  20nMAssay Description:Inhibition of GLS1 (unknown origin)More data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50566576(CHEMBL4876230)
Affinity DataIC50:  21nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 135 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM109086(US10793535, Cmpd ID 727 | US8604016, 670 | US99382...)
Affinity DataIC50:  22nMAssay Description:Inhibition of recombinant human GLS1 expressed in Escherichia coli strain BL21 (DE3) preincubated for 10 mins before glutamine addition and measured ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Affinity DataIC50:  23nMAssay Description:Inhibition of GST-tagged human recombinant VEGFR1 cytoplasmic domain (781 to 1338 residues) expressed in baculovirus expression system using FAM-labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543578(CHEMBL4644718)
Affinity DataIC50:  23nMAssay Description:Inhibition of N-terminal GST fused human recombinant FGFR1 cytoplasmic domain (398 to 822 (end) residues) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50566572(CHEMBL4873504)
Affinity DataIC50:  23nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 135 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543579(CHEMBL4634687)
Affinity DataIC50:  24nMAssay Description:Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50574398(CHEMBL4874803)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant human GLS1 expressed in Escherichia coli strain BL21 (DE3) preincubated for 10 mins before glutamine addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543573(CHEMBL4647154)
Affinity DataIC50:  26nMAssay Description:Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50509188(CHEMBL4566446)
Affinity DataIC50:  27nMAssay Description:Inhibition of human GLS1 expressed in Escherichia coli strain BL21 (DE3)pLysS pre-incubated for 10 mins before glutamine addition and measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50566566(CHEMBL4871378)
Affinity DataIC50:  28nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 135 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50574393(CHEMBL4862317)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant human GLS1 expressed in Escherichia coli strain BL21 (DE3) preincubated for 10 mins before glutamine addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM109086(US10793535, Cmpd ID 727 | US8604016, 670 | US99382...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human GLS1 assessed as reduction in glutamate production in presence of NADPH-dependent glutamate dehydrogenase by coupled biochemical ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543578(CHEMBL4644718)
Affinity DataIC50:  31nMAssay Description:Inhibition of GST-tagged human recombinant VEGFR1 cytoplasmic domain (781 to 1338 residues) expressed in baculovirus expression system using FAM-labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543571(CHEMBL4642920)
Affinity DataIC50:  31nMAssay Description:Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543581(CHEMBL4638817)
Affinity DataIC50:  32nMAssay Description:Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50574391(CHEMBL4858033)
Affinity DataIC50:  32nMAssay Description:Inhibition of recombinant human GLS1 expressed in Escherichia coli strain BL21 (DE3) preincubated for 10 mins before glutamine addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50566564(CHEMBL4875099)
Affinity DataIC50:  36nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 135 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543580(CHEMBL4649259)
Affinity DataIC50:  37nMAssay Description:Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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