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Found 743 with Last Name = 'ramtohul' and Initial = 'yk'
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312702((3-(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-y...)
Affinity DataIC50:  1nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312702((3-(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-y...)
Affinity DataIC50:  1nMAssay Description:Inhibition of SCD1 in human HepG2 cells assessed as [14C]stearic acid to [14C]oleic acid conversion pretreated 15 mins before [14C]stearic acid addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50354672(CHEMBL1834453)
Affinity DataIC50:  1nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50354682(CHEMBL1834455)
Affinity DataIC50:  1nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362592(CHEMBL1938870)
Affinity DataIC50:  1nMAssay Description:Inhibition of human SCD-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50354677(CHEMBL1834443)
Affinity DataIC50:  2nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50:  2nMAssay Description:Inhibition of rat SCD by rat microsomal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50364041(CHEMBL1950551)
Affinity DataIC50:  2nMAssay Description:Inhibition of rat liver microsome SCD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50305768(2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50:  2nMAssay Description:Inhibition of SCD-1 activity in Sprague-Dawley rat microsome assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312684(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)th...)
Affinity DataIC50:  3nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312688(5-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)-1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50354671(CHEMBL1834452)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362592(CHEMBL1938870)
Affinity DataIC50:  3nMAssay Description:Inhibition of mouse SCD-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362592(CHEMBL1938870)
Affinity DataIC50:  3nMAssay Description:Inhibition of SCD-1 activity in Sprague-Dawley rat microsome assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362592(CHEMBL1938870)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat SCD-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362592(CHEMBL1938870)
Affinity DataIC50:  3nMAssay Description:Inhibition of mouse SCD-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312683(2-(4-(2-(trifluoromethyl)phenylthio)piperidin-1-yl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312700(3-(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50354674(CHEMBL1834457)
Affinity DataIC50:  4nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50364040(CHEMBL1950550)
Affinity DataIC50:  5nMAssay Description:Inhibition of rat liver microsome SCD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362592(CHEMBL1938870)
Affinity DataIC50:  5nMAssay Description:Inhibition of SCD-1 activity in human Hepatocytes expressing organic anion transporting polypeptides assessed as reduction in [I-14C] stearoyl CoA de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50356891(CHEMBL1915541)
Affinity DataIC50:  6nMAssay Description:Inhibition of rat SCD by rat microsomal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312688(5-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)-1...)
Affinity DataIC50:  7nMAssay Description:Inhibition of SCD1 in human HepG2 cells assessed as [14C]stearic acid to [14C]oleic acid conversion pretreated 15 mins before [14C]stearic acid addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50354676(CHEMBL1834262)
Affinity DataIC50:  7nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50354667(CHEMBL1834456)
Affinity DataIC50:  7nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50393166(CHEMBL2153601)
Affinity DataIC50:  7nMAssay Description:Inhibition of SCD-1 activity in Sprague-Dawley rat microsome assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312692(3-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)is...)
Affinity DataIC50:  8nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50354684(CHEMBL1834442)
Affinity DataIC50:  8nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362586(CHEMBL1938874)
Affinity DataIC50:  9nMAssay Description:Inhibition of SCD-1 activity in rat liver microsomes assessed as reduction in [1-14C] stearoyl CoA desaturation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362586(CHEMBL1938874)
Affinity DataIC50:  9nMAssay Description:Inhibition of mouse SCD-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312684(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)th...)
Affinity DataIC50:  10nMAssay Description:Inhibition of SCD1 in human HepG2 cells assessed as [14C]stearic acid to [14C]oleic acid conversion pretreated 15 mins before [14C]stearic acid addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50354670(CHEMBL1834451)
Affinity DataIC50:  10nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50354673(CHEMBL1834454)
Affinity DataIC50:  10nMAssay Description:Inhibition of rat SCD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312685((S)-2-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50356892(CHEMBL1915542)
Affinity DataIC50:  12nMAssay Description:Inhibition of rat SCD by rat microsomal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50364036(CHEMBL1950546)
Affinity DataIC50:  13nMAssay Description:Inhibition of rat liver microsome SCD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312692(3-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)is...)
Affinity DataIC50:  14nMAssay Description:Inhibition of SCD1 in human HepG2 cells assessed as [14C]stearic acid to [14C]oleic acid conversion pretreated 15 mins before [14C]stearic acid addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312698(2-(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl...)
Affinity DataIC50:  14nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312701(5-methyl-3-(2-(4-(2-(trifluoromethyl)phenoxy)piper...)
Affinity DataIC50:  15nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312700(3-(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl...)
Affinity DataIC50:  16nMAssay Description:Inhibition of SCD1 in human HepG2 cells assessed as [14C]stearic acid to [14C]oleic acid conversion pretreated 15 mins before [14C]stearic acid addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50354677(CHEMBL1834443)
Affinity DataIC50:  16nMAssay Description:Inhibition of SCD1 in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50354672(CHEMBL1834453)
Affinity DataIC50:  17nMAssay Description:Inhibition of SCD1 in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50362583(CHEMBL1938871)
Affinity DataIC50:  18nMAssay Description:Inhibition of mouse SCD-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50356893(CHEMBL1915543)
Affinity DataIC50:  19nMAssay Description:Inhibition of rat SCD by rat microsomal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase [155-522](Homo sapiens (Human))
Aduro Biotech

US Patent
LigandPNGBDBM457581(US10738056, Compound D1026)
Affinity DataIC50: <20nMAssay Description:Protein was expressed and purified from E. coli BL21 DE3 Rosetta 2 (EMD Millipore) cells using standard techniques. Cells were grown in 2x yeast extr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase [155-522](Homo sapiens (Human))
Aduro Biotech

US Patent
LigandPNGBDBM457582(US10738056, Compound D1027)
Affinity DataIC50: <20nMAssay Description:Protein was expressed and purified from E. coli BL21 DE3 Rosetta 2 (EMD Millipore) cells using standard techniques. Cells were grown in 2x yeast extr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase [155-522](Homo sapiens (Human))
Aduro Biotech

US Patent
LigandPNGBDBM457583(US10738056, Compound D1028)
Affinity DataIC50: <20nMAssay Description:Protein was expressed and purified from E. coli BL21 DE3 Rosetta 2 (EMD Millipore) cells using standard techniques. Cells were grown in 2x yeast extr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase [155-522](Homo sapiens (Human))
Aduro Biotech

US Patent
LigandPNGBDBM457584(US10738056, Compound D1029)
Affinity DataIC50: <20nMAssay Description:Protein was expressed and purified from E. coli BL21 DE3 Rosetta 2 (EMD Millipore) cells using standard techniques. Cells were grown in 2x yeast extr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase [155-522](Homo sapiens (Human))
Aduro Biotech

US Patent
LigandPNGBDBM457585(US10738056, Compound D1030)
Affinity DataIC50: <20nMAssay Description:Protein was expressed and purified from E. coli BL21 DE3 Rosetta 2 (EMD Millipore) cells using standard techniques. Cells were grown in 2x yeast extr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase [155-522](Homo sapiens (Human))
Aduro Biotech

US Patent
LigandPNGBDBM457592(US10738056, Compound D1037)
Affinity DataIC50: <20nMAssay Description:Protein was expressed and purified from E. coli BL21 DE3 Rosetta 2 (EMD Millipore) cells using standard techniques. Cells were grown in 2x yeast extr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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