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Found 397 with Last Name = 'angouillant-boniface' and Initial = 'o'
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059435(CHEMBL3393498)
Affinity DataKi:  990nMAssay Description:Inhibition of human recombinant CYP3A4 in liver microsomes by mechanism based inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM21363(12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triaza...)
Affinity DataKi:  2.47E+3nMAssay Description:Inhibition of human recombinant CYP3A4 in liver microsomes by mechanism based inhibition assayMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059435(CHEMBL3393498)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora A (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059435(CHEMBL3393498)
Affinity DataIC50:  1nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Affinity DataIC50:  1nMAssay Description:Inhibition of aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059432(CHEMBL3393486)
Affinity DataIC50:  2nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059436(CHEMBL3393065)
Affinity DataIC50:  2nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059454(CHEMBL3393470)
Affinity DataIC50:  2nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059443(CHEMBL3393472)
Affinity DataIC50:  2nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059454(CHEMBL3393470)
Affinity DataIC50:  2nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora A (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Sanofi Research & Development

Curated by ChEMBL
LigandPNGBDBM50389047(CHEMBL2064328)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PI3Kbeta-mediated Akt phosphorylation at T308 residue expressed in PTEN-deficient human PC3 cells after 2 hrs by Western blot ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059430(CHEMBL3393488)
Affinity DataIC50:  3nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059435(CHEMBL3393498)
Affinity DataIC50:  3nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora C (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059443(CHEMBL3393472)
Affinity DataIC50:  3nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora A (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059442(CHEMBL3393469)
Affinity DataIC50:  3nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Sanofi Research & Development

Curated by ChEMBL
LigandPNGBDBM50389047(CHEMBL2064328)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Sanofi Research & Development

Curated by ChEMBL
LigandPNGBDBM50365890(CHEMBL1957875)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PI3Kbeta-mediated Akt phosphorylation at T308 residue expressed in PTEN-deficient human PC3 cells after 2 hrs by Western blot ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059442(CHEMBL3393469)
Affinity DataIC50:  3nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059433(CHEMBL3393485)
Affinity DataIC50:  4nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059442(CHEMBL3393469)
Affinity DataIC50:  4nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora A (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059442(CHEMBL3393469)
Affinity DataIC50:  4nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora A (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059445(CHEMBL3393474)
Affinity DataIC50:  4nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora A (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059446(CHEMBL3393475)
Affinity DataIC50:  4nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059450(CHEMBL3393479)
Affinity DataIC50:  4nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora A (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of aurora C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059431(CHEMBL3393487)
Affinity DataIC50:  5nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059461(CHEMBL3393462)
Affinity DataIC50:  5nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059456(CHEMBL3393467)
Affinity DataIC50:  5nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059593(CHEMBL3393484)
Affinity DataIC50:  6nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059447(CHEMBL3393476)
Affinity DataIC50:  6nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059440(CHEMBL3393490)
Affinity DataIC50:  6nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora A (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Sanofi Research & Development

Curated by ChEMBL
LigandPNGBDBM50389048(CHEMBL2064417)
Affinity DataIC50:  6nMAssay Description:Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059445(CHEMBL3393474)
Affinity DataIC50:  6nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059590(CHEMBL3393495)
Affinity DataIC50:  7nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059592(CHEMBL3393494)
Affinity DataIC50:  7nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059449(CHEMBL3393478)
Affinity DataIC50:  7nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059450(CHEMBL3393479)
Affinity DataIC50:  7nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059448(CHEMBL3393477)
Affinity DataIC50:  7nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Sanofi Research & Development

Curated by ChEMBL
LigandPNGBDBM50389048(CHEMBL2064417)
Affinity DataIC50:  8nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059439(CHEMBL3393491)
Affinity DataIC50:  8nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Sanofi Research & Development

Curated by ChEMBL
LigandPNGBDBM50389069(CHEMBL2064344)
Affinity DataIC50:  8nMAssay Description:Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059593(CHEMBL3393484)
Affinity DataIC50:  8nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora A (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059446(CHEMBL3393475)
Affinity DataIC50:  8nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora A (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059451(CHEMBL3393482)
Affinity DataIC50:  8nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Sanofi Research & Development

Curated by ChEMBL
LigandPNGBDBM50389072(CHEMBL2064341)
Affinity DataIC50:  9nMAssay Description:Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Sanofi Research & Development

Curated by ChEMBL
LigandPNGBDBM50389067(CHEMBL2064346)
Affinity DataIC50:  10nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059448(CHEMBL3393477)
Affinity DataIC50:  10nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora A (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059595(CHEMBL3393480)
Affinity DataIC50:  10nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Sanofi Research & Development

Curated by ChEMBL
LigandPNGBDBM50365890(CHEMBL1957875)
Affinity DataIC50:  10nMAssay Description:Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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