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Found 523 with Last Name = 'aoki' and Initial = 'y'
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50088846(CHEMBL353678 | N-{4-[2-(4-Phenyl-piperazin-1-yl)-e...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50088844(4-{4-[4-(4-Phenyl-piperazin-1-yl)-butyl]-phenyl}-t...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50086550(4-Methyl-5-(2,2,4,4-tetramethyl-3-oxo-1,2,3,4-tetr...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to human progesterone receptor by competitive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50088839(CHEMBL169702 | N-{4-[4-(4-Phenyl-piperazin-1-yl)-b...)
Affinity DataKi:  4.60nMAssay Description:In vitro inhibition of human trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(BOVINE)
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50088844(4-{4-[4-(4-Phenyl-piperazin-1-yl)-butyl]-phenyl}-t...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity towards Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50088839(CHEMBL169702 | N-{4-[4-(4-Phenyl-piperazin-1-yl)-b...)
Affinity DataKi:  6nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]-dexamethasone from cytosolic fraction of human recombinant glucocorticoid receptor by scintillation counting analysisMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50088841(CHEMBL352617 | N-{4-[3-(4-Phenyl-piperazin-1-yl)-p...)
Affinity DataKi:  6.40nMAssay Description:In vitro inhibition of human Coagulation factor X.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50088844(4-{4-[4-(4-Phenyl-piperazin-1-yl)-butyl]-phenyl}-t...)
Affinity DataKi:  7.90nMAssay Description:Inhibition of class C beta-lactamase derived from Enterobacter cloacae P99More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50091040(CHEMBL3582119)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-dexamethasone from cytosolic fraction of human recombinant glucocorticoid receptor by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50091046(CHEMBL3582112)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]-dexamethasone from cytosolic fraction of human recombinant glucocorticoid receptor by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]-progesterone from cytosolic fraction of human recombinant progesterone-B receptor by scintillation counting analysisMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50091048(CHEMBL3582109)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]-dexamethasone from cytosolic fraction of human recombinant glucocorticoid receptor by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  20nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50091048(CHEMBL3582109)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]-progesterone from cytosolic fraction of human recombinant progesterone-B receptor by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50091043(CHEMBL3582115)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]-dexamethasone from cytosolic fraction of human recombinant glucocorticoid receptor by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  30nM IC50:  30nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  30nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  30nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  30nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  30nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50088841(CHEMBL352617 | N-{4-[3-(4-Phenyl-piperazin-1-yl)-p...)
Affinity DataKi:  33nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50091036(CHEMBL3582120)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]-dexamethasone from cytosolic fraction of human recombinant glucocorticoid receptor by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50091049(CHEMBL3582125)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]-dexamethasone from cytosolic fraction of human recombinant glucocorticoid receptor by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50088844(4-{4-[4-(4-Phenyl-piperazin-1-yl)-butyl]-phenyl}-t...)
Affinity DataKi:  37nMAssay Description:Inhibition of GC1 extended spectrum class C beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  40nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  40nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50091034(CHEMBL3582121)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]-dexamethasone from cytosolic fraction of human recombinant glucocorticoid receptor by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50088839(CHEMBL169702 | N-{4-[4-(4-Phenyl-piperazin-1-yl)-b...)
Affinity DataKi:  48nMAssay Description:Inhibition of GC1 extended spectrum class C beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(BOVINE)
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50088839(CHEMBL169702 | N-{4-[4-(4-Phenyl-piperazin-1-yl)-b...)
Affinity DataKi:  49nMAssay Description:Binding affinity towards Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM96235(4-[2-hydroxy-3-(isopropylamino)propoxy]-3-methyl-c...)
Affinity DataKi:  50nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  50nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  50nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50091031(CHEMBL3582122)
Affinity DataKi:  53nMAssay Description:Displacement of [3H]-dexamethasone from cytosolic fraction of human recombinant glucocorticoid receptor by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50091044(CHEMBL3582114)
Affinity DataKi:  55nMAssay Description:Displacement of [3H]-dexamethasone from cytosolic fraction of human recombinant glucocorticoid receptor by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50088846(CHEMBL353678 | N-{4-[2-(4-Phenyl-piperazin-1-yl)-e...)
Affinity DataKi:  69nMAssay Description:In vitro inhibition of human trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50091041(CHEMBL3582116)
Affinity DataKi:  69nMAssay Description:Displacement of [3H]-dexamethasone from cytosolic fraction of human recombinant glucocorticoid receptor by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  70nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  70nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  70nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43854(2-[(veratroylhydrazono)methyl]benzoic acid | 2-[[(...)
Affinity DataKi:  80nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  90nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  90nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  100nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50091045(CHEMBL3582113)
Affinity DataKi:  106nMAssay Description:Displacement of [3H]-dexamethasone from cytosolic fraction of human recombinant glucocorticoid receptor by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM43856(4-ethoxy-N-[(6-fluoro-1,1-diketo-2,3-dihydrothioch...)
Affinity DataKi:  110nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50088846(CHEMBL353678 | N-{4-[2-(4-Phenyl-piperazin-1-yl)-e...)
Affinity DataKi:  130nMAssay Description:In vitro inhibition of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50088845(CHEMBL170307 | N-[4-(4-Phenyl-piperazin-1-ylmethyl...)
Affinity DataKi:  140nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
Nippon Roche Research Center

LigandPNGBDBM96235(4-[2-hydroxy-3-(isopropylamino)propoxy]-3-methyl-c...)
Affinity DataKi:  140nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50091054(CHEMBL3582111)
Affinity DataKi:  146nMAssay Description:Displacement of [3H]-dexamethasone from cytosolic fraction of human recombinant glucocorticoid receptor by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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