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Found 172 with Last Name = 'arita' and Initial = 'k'
TargetHistone deacetylase 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50558325(CHEMBL4746359)
Affinity DataIC50:  0.540nMAssay Description:Inhibition of human HDAC1 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50425908(CHEMBL2313363)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of human HDAC1 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50425909(SPIRUCHOSTATIN C)
Affinity DataIC50:  0.930nMAssay Description:Inhibition of human HDAC1 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50558323(CHEMBL4777615)
Affinity DataIC50:  0.960nMAssay Description:Inhibition of human HDAC1 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50558327(CHEMBL4798082)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human HDAC1 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human HDAC1 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50354086(FK-228 | Istodax | ROMIDEPSIN)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of human HDAC1 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50558329(CHEMBL4776416)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human HDAC1 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50558322(CHEMBL4754402)
Affinity DataIC50:  11nMAssay Description:Inhibition of human HDAC1 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50550011(CHEMBL4747168)
Affinity DataIC50:  23nMAssay Description:Inhibition of recombinant human HPGDSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50558324(CHEMBL4796742)
Affinity DataIC50:  41nMAssay Description:Inhibition of human HDAC1 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50558325(CHEMBL4746359)
Affinity DataIC50:  55nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50463722(CHEMBL4238186)
Affinity DataIC50:  71nMAssay Description:Inhibition of recombinant human HPGDS expressed in Escherichia coli BL21 (DE3) measured after 3 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50591607(CHEMBL5193611)
Affinity DataIC50:  78nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50463722(CHEMBL4238186)
Affinity DataIC50:  83nMAssay Description:Inhibition of recombinant human HPGDS using [14C]-PGH2 as substrate preincubated for 1 min in presence of MgCl2 followed by substrate addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50558328(CHEMBL4789369)
Affinity DataIC50:  92nMAssay Description:Inhibition of human HDAC1 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50:  109nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50587270(CHEMBL5076100)
Affinity DataIC50:  117nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50591608(CHEMBL5207946)
Affinity DataIC50:  124nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM136516(US8865714, 3)
Affinity DataIC50:  134nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50587271(CHEMBL5075403)
Affinity DataIC50:  140nMAssay Description:Inhibition of H-PGDS (unknown origin) using fluorescent probe by competition binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50587270(CHEMBL5076100)
Affinity DataIC50:  170nMAssay Description:Inhibition of H-PGDS (unknown origin) using fluorescent probe by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50463722(CHEMBL4238186)
Affinity DataIC50:  170nMAssay Description:Inhibition of H-PGDS (unknown origin) using fluorescent probe by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50558326(CHEMBL4777660)
Affinity DataIC50:  184nMAssay Description:Inhibition of human HDAC1 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50591606(CHEMBL5200341)
Affinity DataIC50:  196nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50463722(CHEMBL4238186)
Affinity DataIC50:  211nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50425908(CHEMBL2313363)
Affinity DataIC50:  240nMAssay Description:Inhibition of mouse HDAC6 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50550010(CHEMBL4762935)
Affinity DataIC50:  266nMAssay Description:Inhibition of recombinant human HPGDS expressed in Escherichia coli BL21 (DE3) measured after 3 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50550009(CHEMBL4758395)
Affinity DataIC50:  300nMAssay Description:Binding affinity to recombinant human HPGDS expressed in Escherichia coli BL21 (DE3) measured after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50550010(CHEMBL4762935)
Affinity DataIC50:  320nMAssay Description:Binding affinity to recombinant human HPGDS expressed in Escherichia coli BL21 (DE3) measured after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50425909(SPIRUCHOSTATIN C)
Affinity DataIC50:  320nMAssay Description:Inhibition of mouse HDAC6 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50550009(CHEMBL4758395)
Affinity DataIC50:  320nMAssay Description:Inhibition of recombinant human HPGDS expressed in Escherichia coli BL21 (DE3) measured after 3 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50463722(CHEMBL4238186)
Affinity DataIC50:  320nMAssay Description:Binding affinity to recombinant human HPGDS expressed in Escherichia coli BL21 (DE3) measured after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50558324(CHEMBL4796742)
Affinity DataIC50:  355nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50354086(FK-228 | Istodax | ROMIDEPSIN)
Affinity DataIC50:  390nMAssay Description:Inhibition of mouse HDAC6 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50354086(FK-228 | Istodax | ROMIDEPSIN)
Affinity DataIC50:  390nMAssay Description:Inhibition of mouse HDAC6 expressed in human 293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50558329(CHEMBL4776416)
Affinity DataIC50:  859nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50354088(CHEMBL1836142)
Affinity DataIC50:  992nMAssay Description:Inhibition of mouse HDAC6 expressed in human 293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50558327(CHEMBL4798082)
Affinity DataIC50:  1.01E+3nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50558326(CHEMBL4777660)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50558328(CHEMBL4789369)
Affinity DataIC50:  1.32E+3nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449386(CHEMBL3126833)
Affinity DataIC50:  1.98E+3nMAssay Description:Inhibition of mouse HDAC6 expressed in human 293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50558322(CHEMBL4754402)
Affinity DataIC50:  2.26E+3nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153597(CHEMBL3775807)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated with substrate for 5 mins followed by NADPH addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153596(CHEMBL3775765)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153598(CHEMBL3775828)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated with substrate for 5 mins followed by NADPH addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50558323(CHEMBL4777615)
Affinity DataIC50:  8.45E+3nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449385(CHEMBL3126831)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse HDAC6 expressed in human 293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153595(CHEMBL3775930)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153594(CHEMBL3774855)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated with substrate for 5 mins followed by NADPH addition me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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