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Found 47 with Last Name = 'babich' and Initial = 'jw'
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50246899((S)-2-(3-((S)-1-carboxy-5-(4-iodobenzamido)pentyl)...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of PSMA in human LNCaP cell extract using [3H]NAAG by radiometric assayMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50246899((S)-2-(3-((S)-1-carboxy-5-(4-iodobenzamido)pentyl)...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of PSMA in human LNCaP cell extract using [3H]NAAG by fluorescence-based assayMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50246934((S)-2-(3-((S)-1-carboxy-5-(4-fluorobenzamido)penty...)
Affinity DataKi:  0.194nMAssay Description:Inhibition of PSMA in human LNCaP cell extract using [3H]NAAG by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50246934((S)-2-(3-((S)-1-carboxy-5-(4-fluorobenzamido)penty...)
Affinity DataKi:  0.256nMAssay Description:Inhibition of PSMA in human LNCaP cell extract using [3H]NAAG by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50246935((S)-2-(3-((S)-1-carboxy-5-(3-iodonicotinamido)pent...)
Affinity DataKi:  0.351nMAssay Description:Inhibition of PSMA in human LNCaP cell extract using [3H]NAAG by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50246935((S)-2-(3-((S)-1-carboxy-5-(3-iodonicotinamido)pent...)
Affinity DataKi:  0.557nMAssay Description:Inhibition of PSMA in human LNCaP cell extract using [3H]NAAG by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265453((S)-2-(3-((S)-1-Carboxy-5-(3-(4-bromophenyl)ureido...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265381((S)-2-(3-((S)-1-Carboxy-5-(4-chlorobenzylamino)pen...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265471((S)-2-(3-((S)-1-Carboxy-5-(3-(4-fluorophenyl)ureid...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265454((S)-2-(3-((S)-1-Carboxy-5-(3-(4-chlorophenyl)ureid...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265783((S)-2-(3-((S)-1-Carboxy-5-(3-(4-iodophenyl)ureido)...)
Affinity DataIC50:  10nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265474((S)-2-(3-((S)-1-Carboxy-5-(4-iodophenylsulfonamido...)
Affinity DataIC50:  10nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265472((S)-2-(3-((S)-1-Carboxy-5-(3-phenylureido)pentyl)u...)
Affinity DataIC50:  12nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265473((9S,13S)-1-(3-iodophenyl)-3,11-dioxo-2,4,10,12-tet...)
Affinity DataIC50:  18nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103917(US8562945, 253)
Affinity DataIC50:  20nMAssay Description:Compounds were tested for their ability to inhibit separase enzyme.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103918(US8562945, 254)
Affinity DataIC50:  21nMAssay Description:Compounds were tested for their ability to inhibit separase enzyme.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265377((S)-2-(3-((S)-1-Carboxy-5-(4-iodobenzylamino)penty...)
Affinity DataIC50:  22nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103909(JNK3 inhibitor 6 | US8562945, 242)
Affinity DataIC50:  23nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265378((S)-2-(3-((S)-1-Carboxy-5-(2-iodobenzylamino)penty...)
Affinity DataIC50:  37nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103908(JNK3 inhibitor 5 | US8562945, 241)
Affinity DataIC50:  40nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103911(JNK3 inhibitor 8 | US8562945, 246)
Affinity DataIC50:  42nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265380((S)-2-(3-((S)-1-Carboxy-5-(4-bromobenzylamino)pent...)
Affinity DataIC50:  43nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103915(US8562945, 250)
Affinity DataIC50:  130nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103911(JNK3 inhibitor 8 | US8562945, 246)
Affinity DataIC50:  140nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265489((S)-2-(3-((S)-1-Carboxy-5-(naphthalen-1-ylmethylam...)
Affinity DataIC50:  154nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103909(JNK3 inhibitor 6 | US8562945, 242)
Affinity DataIC50:  170nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103914(US8562945, 249)
Affinity DataIC50:  189nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265391((S)-2-(3-((S)-1-Carboxy-5-(2-chlorobenzylamino)pen...)
Affinity DataIC50:  245nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103913(US8562945, 248)
Affinity DataIC50:  260nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265451((S)-2-(3-((S)-1-Carboxy-5-(3-chlorobenzylamino)pen...)
Affinity DataIC50:  277nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103912(US8562945, 247)
Affinity DataIC50:  305nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103914(US8562945, 249)
Affinity DataIC50:  405nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265379((S)-2-(3-((S)-1-Carboxy-5-(3-iodobenzylamino)penty...)
Affinity DataIC50:  443nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103908(JNK3 inhibitor 5 | US8562945, 241)
Affinity DataIC50:  445nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265784((S)-2-(3-((S)-5-Amino-1-carboxypentyl)ureido)penta...)
Affinity DataIC50:  498nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103910(JNK3 inhibitor 7 | US8562945, 243)
Affinity DataIC50:  564nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103910(JNK3 inhibitor 7 | US8562945, 243)
Affinity DataIC50:  652nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103915(US8562945, 250)
Affinity DataIC50:  669nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103913(US8562945, 248)
Affinity DataIC50:  770nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265452((S)-2-(3-((S)-1-Carboxy-5-(4-fluorobenzylamino)pen...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103912(US8562945, 247)
Affinity DataIC50:  2.16E+3nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit carbonic anhydrase isozymes II and IX in vito.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265782((S)-2-(3-((S)-5-(Benzylamino)-1-carboxypentyl)urei...)
Affinity DataIC50:  2.96E+3nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Institutions

Curated by ChEMBL
LigandPNGBDBM50265785((S)-2-(3-(4-iodobenzyl)ureido)pentanedioic acid | ...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103916(US8562945, 252)
Affinity DataIC50:  3.53E+3nMAssay Description:Compounds were tested for their ability to inhibit separase enzyme.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103917(US8562945, 253)
Affinity DataIC50:  1.24E+4nMAssay Description:Compounds were tested for their ability to inhibit DPPIV enzyme.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103916(US8562945, 252)
Affinity DataIC50:  1.96E+4nMAssay Description:Compounds were tested for their ability to inhibit DPPIV enzyme.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

US Patent
LigandPNGBDBM103918(US8562945, 254)
Affinity DataIC50:  2.54E+4nMAssay Description:Compounds were tested for their ability to inhibit DPPIV enzyme.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent