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Found 317 with Last Name = 'babiss' and Initial = 'l'
LigandPNGBDBM50557619(CHEMBL4796239)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50557620(CHEMBL4752978)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50438317(CHEMBL2408611)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
LigandPNGBDBM50187111(CHEMBL3823738)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  39nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433293(6-(4-(aminomethyl)-4- methylpiperidin-1-yl)-3- ((2...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433294(6-((2-amino-3- chloropyridin-4-yl)thio)-3- ((3S,4S...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433295(N-(3-((5-(4- (aminomethyl)-4- methylpiperidin-1-yl...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433296(N-(3-((5-(4- (aminomethyl)-4- methylpiperidin-1-yl...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433297(N-(3-((5-(4- (aminomethyl)-4- methylpiperidin-1-yl...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433300(N-(3-((5-(4- (aminomethyl)-4- methylpiperidin-1-yl...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433301(3-((3S,4S)-4-amino-3- methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433302((S)-3-(4-amino-2-oxa-8- azaspiro[4.5]decan-8-yl)- ...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433303(1-(3-aminocyclohexyl)-4- (2,3- dichlorophenyl)pyri...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433304(N-(3-((5-(4- (aminomethyl)-4- methylpiperidin-1-yl...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433305(3-((3S,4S)-4-amino-3- methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433306(3-((3S,4S)-4-amino-3- methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433307(3-((3S,4S)-4-amino-3- methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433308(4-((5-(4-(aminomethyl)-4- methylpiperidin-1-yl)-6-...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433309(3-((3S,4S)-4-amino-3- methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433310(3-((3S,4S)-4-amino-3- methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433311(3-((3S,4S)-4-amino-3- methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433314(3-(6-amino-3- azabicyclo[3.1.0]hexan-3- yl)-6-((2,...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433316((R)-3-(3-amino-3H- spiro[benzofuran-2,4'- piperidi...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433317((S)-3-(4-amino-2-oxa-8- azaspiro[4.5]decan-8-yl)- ...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433315((S)-3-(1-amino-1,3- dihydrospiro[indene-2,4'- pipe...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433291(6-(4-(aminomethyl)-4- methylpiperidin-1-yl)-3- (2,...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433313(3-(2- aminospiro[bicyclo[3.1.0] hexane-3,4'-piperi...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433312(3-((3S,4S)-4-amino-3- methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433298(N-(3-((5-(4- (aminomethyl)-4- methylpiperidin-1-yl...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433290(3-(4-(aminomethyl)-4- methylpiperidin-1-yl)-6- ((2...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Synblia Therapeutics

US Patent
LigandPNGBDBM433292(6-amino-2-(3- (aminomethyl)-3- methylpyrrolidin-1-...)
Affinity DataIC50: <50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50557622(CHEMBL4786426)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50557633(CHEMBL4795442)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369905((R)—N-(1-Cyclohexyl-2-(3-methyl-2,4-dioxo-1-p...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM369906(2-Fluoro-3-methyl-N-((2R,3R)-3-methyl-1-(3-methyl-...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM369909((R)—N-(1-(3-(Cyanomethyl)-1-(4-methoxyphenyl)...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM369910((R)-2-Fluoro-N-(1-(1-(3-fluoro-4-methoxyphenyl)-3-...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM369911((R)—N-(1-(1-(4-Cyanophenyl)-3-methyl-2,4-diox...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM369912((R)—N-(1-(1-(3-Cyanophenyl)-3-methyl-2,4-diox...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM369913((R)-2-Fluoro-N-(1-(1-(3-methoxyphenyl)-3-methyl-2,...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM369914((R)-2-Fluoro-N-(3-methyl-1-(3-methyl-1-(1-methyl-1...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM369915((R)-2-Fluoro-N-(3-methyl-1-(3-methyl-1-(2-methyl-2...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM369916((R)-2-Fluoro-N-(1-(1-(imidazo[1,2-a]pyridin-6-yl)-...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM369918((R)-5-Ethyl-2-fluoro-N-(3-methyl-1-(3-methyl-1-(3-...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM369919((R)-2-Fluoro-N-(3-methyl-1-(3-methyl-2,4-dioxo-1-(...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM369920((R)—N-(1-(1-(3,4-Dihydro-2H-benzo[b][1,4]oxaz...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM369921((R)—N-(1-Cyclopentyl-2-(3-methyl-1-(1-methyl-...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM369922((R)-2-Fluoro-N-(1-(1-(6-methoxypyridin-3-yl)-3-met...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM369923((R)-2-Fluoro-N-(3-methyl-1-(3-methyl-2,4-dioxo-1-(...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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