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Found 155 with Last Name = 'baldwin' and Initial = 'ag'
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591091(CHEMBL5169387)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1/2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  3nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591091(CHEMBL5169387)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
TargetToll-like receptor 4(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50155929(CHEMBL225157 | TAK-242)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of TLR4 in LPS/INFgamma stimulated mouse peritoneal macrophages assessed as inhibition of IL1-beta after 20 hrs by ELISA analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591314(CHEMBL5202859)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50043510(CHEMBL3355507)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591090(CHEMBL2141887)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591091(CHEMBL5169387)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50044004(CHEMBL3356433)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591091(CHEMBL5169387)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50043501(CHEMBL3355509)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of NLRP3 in mouse BMDM cells preincubated for 30 mins followed by ATP addition by ELISA analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591314(CHEMBL5202859)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50043501(CHEMBL3355509)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50044004(CHEMBL3356433)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50044004(CHEMBL3356433)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50043510(CHEMBL3355507)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591082(CHEMBL4790618)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591082(CHEMBL4790618)
Affinity DataIC50:  15nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591311(CHEMBL3182065)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591311(CHEMBL3182065)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  21nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  21nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50044004(CHEMBL3356433)
Affinity DataIC50:  23nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591090(CHEMBL2141887)
Affinity DataIC50:  26nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591091(CHEMBL5169387)
Affinity DataIC50:  26nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591091(CHEMBL5169387)
Affinity DataIC50:  27nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591311(CHEMBL3182065)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1/2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50:  32nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591090(CHEMBL2141887)
Affinity DataIC50:  33nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50388602(FURAMIDINE)
Affinity DataIC50:  35nMAssay Description:Inhibition of recombinant human NQO2 assessed as change in rate of decolouration of DCPIP measured over 1 min by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50:  39nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1/2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591311(CHEMBL3182065)
Affinity DataIC50:  40nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591084(CHEMBL5186508)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLIM domain kinase 1/2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591090(CHEMBL2141887)
Affinity DataIC50:  44nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591084(CHEMBL5186508)
Affinity DataIC50:  50nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50043510(CHEMBL3355507)
Affinity DataIC50:  56nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50390791(CHEMBL2070615)
Affinity DataIC50:  56nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  59nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50461058(CHEMBL3771399)
Affinity DataIC50:  68nMAssay Description:Inhibition of recombinant human NQO2 assessed as change in rate of decolouration of DCPIP measured over 1 min by spectrophotometric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50:  69nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591090(CHEMBL2141887)
Affinity DataIC50:  71nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
TargetLIM domain kinase 1/2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  74nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591090(CHEMBL2141887)
Affinity DataIC50:  76nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
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