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Found 62 with Last Name = 'barbosa' and Initial = 'sa'
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5668(2-amino-5-thio-substituted thiazole 45 | BMS-38703...)
Affinity DataIC50:  3nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5924(BMS-387032 analog 14 | N-(5-{[(5-tert-butyl-1,3-ox...)
Affinity DataIC50:  3nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5660(2-amino-5-thio-substituted thiazole 25 | 2-aminoth...)
Affinity DataIC50:  5nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5930(BMS-387032 analog 20 | N-(5-{[(5-tert-butyl-1,3-ox...)
Affinity DataIC50:  11nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176588(3-acetamido-N-(3-cyano-5-methyl-4-(4-phenoxyphenyl...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5934(BMS-387032 analog 24 | N-(5-{[(5-tert-butyl-1,3-ox...)
Affinity DataIC50:  18nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176580(1-(3-cyano-5-methyl-4-(4-phenoxyphenylamino)H-pyrr...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5923(3-amino-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methy...)
Affinity DataIC50:  21nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5936(4-amino-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methy...)
Affinity DataIC50:  22nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176569(CHEMBL201389 | methyl 3-cyano-5-methyl-4-(4-phenox...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176595(CHEMBL377288 | ethyl 3-cyano-4-(4-(2-methoxyphenox...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176559(1-(3-cyano-4-(4-(2-methoxyphenoxy)phenylamino)-5-m...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5683(2-amino-5-thio-substituted thiazole 31 | BMS-38703...)
Affinity DataIC50:  26nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176593(1-(3-cyano-4-(4-(3-methoxyphenoxy)phenylamino)-5-m...)
Affinity DataIC50:  29nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176592(1-(3-cyano-4-(4-(2-fluorophenoxy)phenylamino)-5-me...)
Affinity DataIC50:  33nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176572(1-(3-cyano-5-methyl-4-(4-phenoxyphenylamino)H-pyrr...)
Affinity DataIC50:  36nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176586(CHEMBL202063 | N-(3-cyano-5-methyl-4-(4-phenoxyphe...)
Affinity DataIC50:  42nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5932(1-Methyl-N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]...)
Affinity DataIC50:  43nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5931(BMS-387072 | CHEMBL296468 | N-(5-{[(5-tert-butyl-1...)
Affinity DataIC50:  48nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176567(2-morpholinoethyl 3-cyano-4-(4-(2-methoxyphenoxy)p...)
Affinity DataIC50:  48nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5928((+/-)-N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]met...)
Affinity DataIC50:  50nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5926(BMS-387032 analog 16 | N-(5-{[(5-tert-butyl-1,3-ox...)
Affinity DataIC50:  50nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176564(2-morpholinoethyl 3-cyano-5-methyl-4-(4-phenoxyphe...)
Affinity DataIC50:  58nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176565(CHEMBL202385 | ethyl 4-(4-benzylphenylamino)-3-cya...)
Affinity DataIC50:  68nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5933(BMS-387032 analog 23 | N-(5-{[(5-tert-butyl-1,3-ox...)
Affinity DataIC50:  74nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176576(2-morpholinoethyl 3-cyano-4-(4-(3-methoxyphenoxy)p...)
Affinity DataIC50:  76nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5929((+/-)-N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]met...)
Affinity DataIC50:  83nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176571(CHEMBL201819 | N-(3-cyano-5-methyl-4-(4-phenoxyphe...)
Affinity DataIC50:  87nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176603(CHEMBL380765 | ethyl 3-cyano-5-methyl-4-(4-phenoxy...)
Affinity DataIC50:  94nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176575(3-cyano-5-methyl-4-(4-phenoxyphenylamino)H-pyrrolo...)
Affinity DataIC50:  147nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5937(4-amino-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methy...)
Affinity DataIC50:  150nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5935(BMS-387032 analog 25 | N-[5-[[[5-(1,1-Dimethylethy...)
Affinity DataIC50:  160nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176584(6-(1H-benzo[d]imidazol-2-yl)-5-methyl-4-(4-phenoxy...)
Affinity DataIC50:  168nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176601(6-hydroxy-5-methyl-4-(4-phenoxyphenylamino)H-pyrro...)
Affinity DataIC50:  181nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176583(6-amino-5-methyl-4-(4-phenoxyphenylamino)H-pyrrolo...)
Affinity DataIC50:  190nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176591(CHEMBL382456 | ethyl 3-cyano-5-(methoxymethyl)-4-(...)
Affinity DataIC50:  191nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176560(CHEMBL201186 | ethyl 3-cyano-5-(hydroxymethyl)-4-(...)
Affinity DataIC50:  203nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176581(5-methyl-4-(4-phenoxyphenylamino)H-pyrrolo[1,2-b]p...)
Affinity DataIC50:  241nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5927(BMS-387032 analog 17 | N-(5-{[(5-tert-butyl-1,3-ox...)
Affinity DataIC50:  300nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176602(CHEMBL371969 | ethyl 3-cyano-5-(ethoxymethyl)-4-(4...)
Affinity DataIC50:  331nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176570(5-methyl-4-(4-phenoxyphenylamino)-6-(phenylamino)H...)
Affinity DataIC50:  361nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176573(3-cyano-5-methyl-N-(2-morpholinoethyl)-4-(4-phenox...)
Affinity DataIC50:  386nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176562(3-cyano-N,5-dimethyl-4-(4-phenoxyphenylamino)H-pyr...)
Affinity DataIC50:  397nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176566(5-methyl-6-(2-morpholinoethoxy)-4-(4-phenoxyphenyl...)
Affinity DataIC50:  521nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176599(CHEMBL201302 | ethyl 3-cyano-5-((2-methoxyethoxy)m...)
Affinity DataIC50:  566nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176578(CHEMBL203414 | ethyl 4-(4-(4-chlorophenoxy)phenyla...)
Affinity DataIC50:  642nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176563(6-methoxy-5-methyl-4-(4-phenoxyphenylamino)H-pyrro...)
Affinity DataIC50:  805nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176597(CHEMBL202545 | ethyl 4-(4-benzoylphenylamino)-3-cy...)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176577(CHEMBL201246 | ethyl 3-cyano-5-methyl-4-(4-(phenyl...)
Affinity DataIC50:  2.32E+3nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176579(CHEMBL383098 | ethyl 3-cyano-5-methyl-4-(3-phenoxy...)
Affinity DataIC50:  2.65E+3nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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