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Found 1039 with Last Name = 'barker' and Initial = 'd'
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataKi:  0.0398nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50519160(CHEMBL4468357)
Affinity DataKi:  0.107nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50519162(CHEMBL4573716)
Affinity DataKi:  0.174nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataKi:  2nMAssay Description:Inhibition of integrin alphavbeta1 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataKi:  10nMAssay Description:Inhibition of integrin alphavbeta5 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataKi:  40nMAssay Description:Inhibition of integrin alphavbeta3 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-phosphatidylinositol phosphodiesterase(Bacillus cereus)
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50555554(CHEMBL4751563)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibition of Bacillus cereus phospholipase C by amplex red assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1-phosphatidylinositol phosphodiesterase(Bacillus cereus)
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50555553(CHEMBL4764001)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of Bacillus cereus phospholipase C using L-alpha-phosphatidylcholine as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1-phosphatidylinositol phosphodiesterase(Bacillus cereus)
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50555552(CHEMBL4785156)
Affinity DataKi:  7.10E+4nMAssay Description:Inhibition of Bacillus cereus PC-phospholipase C using phosphoryl-choline as substrate by molybdenum blue dye based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415001(CHEMBL570015 | GSK-256066 | GSK-256066 (3))
Affinity DataIC50:  0.00794nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414999(CHEMBL569791)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415009(CHEMBL571381)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415008(CHEMBL584327)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414998(CHEMBL569556)
Affinity DataIC50:  0.126nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585514(CHEMBL5086526)
Affinity DataIC50:  0.158nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585527(CHEMBL5084861)
Affinity DataIC50: >0.158nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585515(CHEMBL5076189)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585527(CHEMBL5084861)
Affinity DataIC50:  0.316nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585515(CHEMBL5076189)
Affinity DataIC50:  0.316nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Affinity DataIC50:  0.398nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585514(CHEMBL5086526)
Affinity DataIC50:  0.398nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188514(4,7,7-trimethyl-4-phenyl-3-(trifluoromethyl)-2,4,6...)
Affinity DataIC50:  0.400nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585507(CHEMBL5078141)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585519(CHEMBL5075556)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585527(CHEMBL5084861)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585519(CHEMBL5075556)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585505(CHEMBL5078647)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585515(CHEMBL5076189)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585519(CHEMBL5075556)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585516(CHEMBL5075673)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415007(CHEMBL571171)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414992(CHEMBL576479)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585501(CHEMBL5084542)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585501(CHEMBL5084542)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585501(CHEMBL5084542)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585505(CHEMBL5078647)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585505(CHEMBL5078647)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50497716(CHEMBL3319237)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of integrin alphavbeta3 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585509(CHEMBL5085176)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585514(CHEMBL5086526)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50497714(Glpg-0187 | Glpg0187)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of ligand binding to integrin alphavbeta8 (unknown origin) expressed in baculovirus expression system after 2 hrs by solid-phase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50497714(Glpg-0187 | Glpg0187)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of ligand binding to integrin alphavbeta1 (unknown origin) expressed in baculovirus expression system after 2 hrs by solid-phase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585508(CHEMBL5079248)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585507(CHEMBL5078141)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585504(CHEMBL5084340)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585502(CHEMBL5082928)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50497714(Glpg-0187 | Glpg0187)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of ligand binding to integrin alphavbeta6 (unknown origin) expressed in baculovirus expression system after 2 hrs by solid-phase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50497716(CHEMBL3319237)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413291(CHEMBL515240)
Affinity DataIC50:  1.58nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415000(CHEMBL570029)
Affinity DataIC50:  1.58nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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