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Found 293 with Last Name = 'bax' and Initial = 'bd'
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50172920(3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(pip...)
Affinity DataIC50:  1.26nMAssay Description:Inhibition of JNK3 by high throughput screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50172920(3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(pip...)
Affinity DataIC50:  3.98nMAssay Description:Inhibition of p38alpha by high throughput screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50178832(CHEMBL203535 | N-(2'-(phenylamino)-4,4'-bipyridin-...)
Affinity DataIC50:  6.31nMAssay Description:Inhibition of JNK3 by high throughput screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50510295(CHEMBL4443422)
Affinity DataIC50:  40nMAssay Description:Inhibition of Escherichia coli his-tagged DNA gyrase supercoiling activity using pBR322 DNA in presence of ATP incubated for 1 hr by H19 dye based hi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415616(CHEMBL1087421)
Affinity DataIC50:  50.1nMAssay Description:Inhibition of N-terminal histidine-tagged human full length JNK3 by radiometric filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50172920(3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(pip...)
Affinity DataIC50:  79.4nMAssay Description:Inhibition of JNK1 by high throughput screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50334942(1-{4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human CYP1A2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8370(N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropan...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against bovine mitochondrial F1F0-ATP synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50279327(CHEMBL4165288)
Affinity DataIC50:  100nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate pretreated for 15 mins followed by substrate addition measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415620(CHEMBL1088633)
Affinity DataIC50:  126nMAssay Description:Inhibition of N-terminal histidine-tagged human full length JNK3 by radiometric filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50279329(CHEMBL4161596)
Affinity DataIC50:  126nMAssay Description:Inhibition of PIM1 (unknown origin) using TAMRA-ERMRPRKRQGSVRRRV-NH2 as substrate pretreated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50510288(CHEMBL4445556)
Affinity DataIC50:  160nMAssay Description:Inhibition of Escherichia coli his-tagged DNA gyrase supercoiling activity using pBR322 DNA in presence of ATP incubated for 1 hr by H19 dye based hi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50510294(CHEMBL4592805)
Affinity DataIC50:  160nMAssay Description:Inhibition of Escherichia coli his-tagged DNA gyrase supercoiling activity using pBR322 DNA in presence of ATP incubated for 1 hr by H19 dye based hi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50178832(CHEMBL203535 | N-(2'-(phenylamino)-4,4'-bipyridin-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of p38alpha by high throughput screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50334936(CHEMBL1649665 | N-cyclopentyl-2-{4-[3-(trifluorome...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415620(CHEMBL1088633)
Affinity DataIC50:  251nMAssay Description:Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50334935(1-{4-[1-(1-pyrrolidinylcarbonyl)cyclopropyl]phenyl...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50279345(CHEMBL4172211)
Affinity DataIC50:  316nMAssay Description:Inhibition of PIM1 (unknown origin) using TAMRA-ERMRPRKRQGSVRRRV-NH2 as substrate pretreated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415616(CHEMBL1087421)
Affinity DataIC50:  316nMAssay Description:Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50178832(CHEMBL203535 | N-(2'-(phenylamino)-4,4'-bipyridin-...)
Affinity DataIC50:  398nMAssay Description:Inhibition of JNK1 by high throughput screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415612(CHEMBL1083185)
Affinity DataIC50:  398nMAssay Description:Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropyMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50510286(CHEMBL4467227)
Affinity DataIC50:  500nMAssay Description:Inhibition of Escherichia coli his-tagged DNA gyrase supercoiling activity using pBR322 DNA in presence of ATP incubated for 1 hr by H19 dye based hi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50510292(CHEMBL4471339)
Affinity DataIC50:  500nMAssay Description:Inhibition of Escherichia coli his-tagged DNA gyrase supercoiling activity using pBR322 DNA in presence of ATP incubated for 1 hr by H19 dye based hi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50279329(CHEMBL4161596)
Affinity DataIC50:  501nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate pretreated for 15 mins followed by substrate addition measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8370(N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropan...)
Affinity DataIC50:  501nMAssay Description:Inhibition of PIM1 (unknown origin) using TAMRA-ERMRPRKRQGSVRRRV-NH2 as substrate pretreated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50323798(CHEMBL1214336 | N-[5-(3-pyridinyl)-2,3-dihydro-1H-...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human CYP1A2 after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415624(CHEMBL1077129)
Affinity DataIC50:  631nMAssay Description:Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50279345(CHEMBL4172211)
Affinity DataIC50:  631nMAssay Description:Inhibition of GSK3beta (unknown origin) after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50334936(CHEMBL1649665 | N-cyclopentyl-2-{4-[3-(trifluorome...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human CYP3A4 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415616(CHEMBL1087421)
Affinity DataIC50:  794nMAssay Description:Inhibition of N-terminal histidine-tagged human full length JNK2-alpha-2 by radiometric filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415614(CHEMBL1088053)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50279347(CHEMBL4163479)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate pretreated for 15 mins followed by substrate addition measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50334939(1-({4-[3-(Trifluoromethyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human CYP1A2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50334948(CHEMBL1649654 | N-methyl-N-(2-phenylethyl)-4-[3-(t...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50334940(1-{4-[1-methyl-2-oxo-2-(1-pyrrolidinyl)ethyl]pheny...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415620(CHEMBL1088633)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of N-terminal histidine-tagged human full length JNK2-alpha-2 by radiometric filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50279328(CHEMBL4176717)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of GSK3beta (unknown origin) after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50279329(CHEMBL4161596)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of human GSK3beta using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50279344(CHEMBL4174177)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of GSK3beta (unknown origin) after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50279344(CHEMBL4174177)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate pretreated for 15 mins followed by substrate addition measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50510293(CHEMBL4528547)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of Escherichia coli his-tagged DNA gyrase supercoiling activity using pBR322 DNA in presence of ATP incubated for 1 hr by H19 dye based hi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50510289(CHEMBL4588294)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of Escherichia coli his-tagged DNA gyrase supercoiling activity using pBR322 DNA in presence of ATP incubated for 1 hr by H19 dye based hi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50279344(CHEMBL4174177)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of PIM1 (unknown origin) using TAMRA-ERMRPRKRQGSVRRRV-NH2 as substrate pretreated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415621(CHEMBL1088634)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50334937(1-({2-Fluoro-4-[3-(trifluoromethyl)-4,5,6,7-tetrah...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human CYP1A2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50334949(1-{4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human CYP2C19 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50334947(CHEMBL1649655 | N,N-dimethyl-4-[3-(trifluoromethyl...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50510287(CHEMBL4468900)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Escherichia coli his-tagged DNA gyrase supercoiling activity using pBR322 DNA in presence of ATP incubated for 1 hr by H19 dye based hi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50279327(CHEMBL4165288)
Affinity DataIC50:  2.51E+3nMAssay Description:Inhibition of PIM1 (unknown origin) using TAMRA-ERMRPRKRQGSVRRRV-NH2 as substrate pretreated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50279328(CHEMBL4176717)
Affinity DataIC50:  2.51E+3nMAssay Description:Inhibition of PIM1 (unknown origin) using TAMRA-ERMRPRKRQGSVRRRV-NH2 as substrate pretreated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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