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Found 226 with Last Name = 'becker' and Initial = 'k'
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182122(CHEMBL204688 | bis(2,4-dinitrophenyl)sulfane)
Affinity DataKi:  200nMAssay Description:Binding affinity to Plasmodium falciparum TrxR in presence of thioredoxinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182122(CHEMBL204688 | bis(2,4-dinitrophenyl)sulfane)
Affinity DataKi:  200nMAssay Description:Binding affinity to Plasmodium falciparum TrxR in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182128(4-nitrobenzo[c][1,2,5]thiadiazole | CHEMBL383084)
Affinity DataKi:  650nMAssay Description:Binding affinity to Plasmodium falciparum TrxR in presence of thioredoxinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182128(4-nitrobenzo[c][1,2,5]thiadiazole | CHEMBL383084)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to Plasmodium falciparum TrxR in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50176071(2-(2-Amino-ethylamino)-N-(7-{2-[N'-(5-nitro-furan-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50121447(5-Nitro-furan-2-carboxylic acid N'-(2-naphthalen-2...)
Affinity DataIC50:  4.10nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM238895(US10053433, Casodex (CDX) | US10053433, FC 4.037 (...)
Affinity DataIC50:  15nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM238895(US10053433, Casodex (CDX) | US10053433, FC 4.037 (...)
Affinity DataIC50:  190nMpH: 7.5Assay Description:An AR-response element is contained within the mmTV sequence and drives the expression of luciferase. The effect of antiandrogens (competitive antago...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM238895(US10053433, Casodex (CDX) | US10053433, FC 4.037 (...)
Affinity DataIC50:  360nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM239191(US10053433, FC 3.077)
Affinity DataIC50:  490nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182122(CHEMBL204688 | bis(2,4-dinitrophenyl)sulfane)
Affinity DataIC50:  500nMAssay Description:Inhibition of Plasmodium falciparum TrxRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM242618(US10053433, FC 4.025)
Affinity DataIC50:  580nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096035(6-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  750nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM242588(US10053433, FC 4.039)
Affinity DataIC50:  750nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396489(CHEMBL2170943)
Affinity DataIC50:  900nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 2 hrs by resazurin/diaphorasecoupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM238895(US10053433, Casodex (CDX) | US10053433, FC 4.037 (...)
Affinity DataIC50:  1.00E+3nMpH: 7.5Assay Description:An AR-response element is contained within the mmTV sequence and drives the expression of luciferase. The effect of antiandrogens (competitive antago...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096062(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM242618(US10053433, FC 4.025)
Affinity DataIC50:  1.29E+3nMpH: 7.5Assay Description:An AR-response element is contained within the mmTV sequence and drives the expression of luciferase. The effect of antiandrogens (competitive antago...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096035(6-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  1.30E+3nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396486(CHEMBL2171113)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 45 mins by orthogonal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396521(CHEMBL2170936)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 2 hrs by resazurin/diaphorasecoupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM239363(US10053433, FC 4.126)
Affinity DataIC50:  1.55E+3nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396519(CHEMBL2170938)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 2 hrs by resazurin/diaphorasecoupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396486(CHEMBL2171113)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 2 hrs by resazurin/diaphorasecoupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396489(CHEMBL2170943)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 45 mins by orthogonal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM50425732(ENZALUTAMIDE | US10053433, FC 4.129 | US10806720, ...)
Affinity DataIC50:  1.94E+3nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182128(4-nitrobenzo[c][1,2,5]thiadiazole | CHEMBL383084)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Plasmodium falciparum TrxRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182124(6,7-dinitroquinoxaline | CHEMBL380953)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Plasmodium falciparum TrxRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic/2, mitochondrial/3(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182130(4,6-dinitrobenzo[c][1,2,5]thiadiazole | CHEMBL2061...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human TrxRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396521(CHEMBL2170936)
Affinity DataIC50:  2.06E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 45 mins by orthogonal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396522(CHEMBL2170935)
Affinity DataIC50:  2.35E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 2 hrs by resazurin/diaphorasecoupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396517(CHEMBL2170940)
Affinity DataIC50:  2.39E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 2 hrs by resazurin/diaphorasecoupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096062(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  2.50E+3nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM239316(US10053433, FC 4.116)
Affinity DataIC50:  2.53E+3nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396488(CHEMBL2170929)
Affinity DataIC50:  2.56E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 2 hrs by resazurin/diaphorasecoupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  2.60E+3nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396519(CHEMBL2170938)
Affinity DataIC50:  2.61E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 45 mins by orthogonal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096071(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  2.70E+3nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396517(CHEMBL2170940)
Affinity DataIC50:  2.88E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 45 mins by orthogonal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396515(CHEMBL2170945)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 2 hrs by resazurin/diaphorasecoupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM50094975(956104-40-8 | ARN-509 | JNJ-56021927 | US10053433,...)
Affinity DataIC50:  3.11E+3nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM50094975(956104-40-8 | ARN-509 | JNJ-56021927 | US10053433,...)
Affinity DataIC50:  3.28E+3nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396488(CHEMBL2170929)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 45 mins by orthogonal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396520(CHEMBL2170937)
Affinity DataIC50:  3.89E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 45 mins by orthogonal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396515(CHEMBL2170945)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 45 mins by orthogonal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic/2, mitochondrial/3(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182122(CHEMBL204688 | bis(2,4-dinitrophenyl)sulfane)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human TrxRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096071(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  4.00E+3nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396522(CHEMBL2170935)
Affinity DataIC50:  4.13E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 45 mins by orthogonal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate dehydrogenase(Plasmodium falciparum)
University Of California

Curated by ChEMBL
LigandPNGBDBM50396518(CHEMBL2170939)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 45 mins by orthogonal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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