Affinity DataKi: 2.10nMAssay Description:Inhibition of DPP4 in rat plasmaMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 2.80E+3nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 9.90E+3nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 1.40E+4nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 1.40E+4nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 2.50E+4nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 2.90E+4nMAssay Description:Dissociation constant of the compound towards SHP 1 receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of DPP3More data for this Ligand-Target Pair
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of DPP2More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 4.30E+4nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 5.60E+4nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 8.10E+4nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 9.20E+4nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 1.28E+5nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 1.73E+5nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 1.93E+5nMAssay Description:Dissociation constant of the compound towards SHP 1 receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 1.95E+5nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: >2.00E+5nMAssay Description:Dissociation constant of the compound towards SHP 1 receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 2.20E+5nMAssay Description:Dissociation constant of the compound towards SHP 1 receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 3.80E+5nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 4.80E+5nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 7.60E+5nMAssay Description:Dissociation constant of the compound towards SHP 1 receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 1.40E+6nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 2.50E+6nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 1.75E+7nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataKi: 7.70E+7nMAssay Description:Dissociation constant of the compound towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 0.840nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human ACC2 using acetyl-CoA as substrate assessed as [14C]malonyl-CoA synthesis preincubated for 10 mins prior to substrate addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human ACC1 using acetyl-CoA as substrate assessed as [14C]malonyl-CoA synthesis preincubated for 10 mins prior to substrate addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human ACC2 using acetyl-CoA as substrate assessed as [14C]malonyl-CoA synthesis preincubated for 10 mins prior to substrate addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human ACC2 using acetyl-CoA as substrate assessed as [14C]malonyl-CoA synthesis preincubated for 10 mins prior to substrate addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Concentration required for 50% for in vitro activity against human SDH (sorbitol dehydrogenase)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Concentration required for 50% for in vitro activity against human SDH (sorbitol dehydrogenase)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human ACC2 using acetyl-CoA as substrate assessed as [14C]malonyl-CoA synthesis preincubated for 10 mins prior to substrate addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human ACC2 using acetyl-CoA as substrate assessed as [14C]malonyl-CoA synthesis preincubated for 10 mins prior to substrate addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human ACC2 using acetyl-CoA as substrate assessed as [14C]malonyl-CoA synthesis preincubated for 10 mins prior to substrate addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human ACC2 using acetyl-CoA as substrate assessed as [14C]malonyl-CoA synthesis preincubated for 10 mins prior to substrate addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant rat sorbitol dehydrogenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human ACC2 using acetyl-CoA as substrate assessed as [14C]malonyl-CoA synthesis preincubated for 10 mins prior to substrate addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Concentration required for 50% in vitro activity against rat SDH (sorbitol dehydrogenase)More data for this Ligand-Target Pair