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Found 122 with Last Name = 'bender' and Initial = 'pe'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50042058((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Affinity DataIC50:  5nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472190(CHEMBL167638)
Affinity DataIC50:  5nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472191(CHEMBL167166)
Affinity DataIC50:  40nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472193(CHEMBL352628)
Affinity DataIC50:  44nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472187(CHEMBL169746)
Affinity DataIC50:  45nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50042056((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Affinity DataIC50:  45nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230001(4-(4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazo...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403407(CHEMBL17210)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403384(CHEMBL17445)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50104352(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM13531(4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridy...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472198(CHEMBL354447)
Affinity DataIC50:  52nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472189(CHEMBL167486)
Affinity DataIC50:  70nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403386(CHEMBL417087)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472199(CHEMBL169537)
Affinity DataIC50:  80nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403376(CHEMBL17389)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50:  95nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50:  95nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50104373(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472197(CHEMBL352857)
Affinity DataIC50:  110nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50:  120nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472193(CHEMBL352628)
Affinity DataIC50:  120nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284507(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403397(CHEMBL17334)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472189(CHEMBL167486)
Affinity DataIC50:  120nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50:  120nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472192(CHEMBL167258)
Affinity DataIC50:  120nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403404(CHEMBL17346)
Affinity DataIC50:  190nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472191(CHEMBL167166)
Affinity DataIC50:  195nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284506(4-[5-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403392(CHEMBL17293)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403402(CHEMBL17493)
Affinity DataIC50:  270nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284483((3-{4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imida...)
Affinity DataIC50:  290nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472199(CHEMBL169537)
Affinity DataIC50:  300nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50042058((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Affinity DataIC50:  300nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50104356(4-[5-(4-Fluoro-phenyl)-2-phenyl-3H-imidazol-4-yl]-...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472195(CHEMBL166529)
Affinity DataIC50:  320nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472198(CHEMBL354447)
Affinity DataIC50:  320nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472194(CHEMBL169834)
Affinity DataIC50:  340nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284516(2,4,5-Triarylimidazole analogue | CHEMBL16925)
Affinity DataIC50:  350nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284513(CHEMBL17325 | {4-[4-(4-Fluoro-phenyl)-5-pyridin-4-...)
Affinity DataIC50:  350nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50104355(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  370nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50104351(4-[5-(4-Fluoro-phenyl)-2-(4-methoxy-phenyl)-3H-imi...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284487((1Z)-N'-cyano-2-{4-[4-(4-fluorophenyl)-5-pyridin-4...)
Affinity DataIC50:  420nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284492(4-[5-(4-Fluoro-phenyl)-2-(4-methanesulfinyl-phenyl...)
Affinity DataIC50:  430nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403381(CHEMBL17480)
Affinity DataIC50:  440nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50110200(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50:  500nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472187(CHEMBL169746)
Affinity DataIC50:  500nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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