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Found 63 with Last Name = 'bera' and Initial = 's'
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144942(2'-C-Me-guanosine | 2'-C-methyl-guanosine | 2'-C-m...)
Affinity DataIC50:  130nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468707(CHEMBL4290935)
Affinity DataIC50:  290nMAssay Description:Antagonist activity at smo in SAG-treated mouse Light2 cells after 48 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144937(2-Amino-9-((2R,3R,5S)-3-hydroxy-5-hydroxymethyl-te...)
Affinity DataIC50:  600nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144947(2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144938(2-Amino-9-((2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-hydr...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144948((2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxy...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468718(CHEMBL4290044)
Affinity DataIC50:  2.58E+3nMAssay Description:Antagonist activity at smo in SAG-treated mouse Light2 cells after 48 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144949((2R,3R,4R,5R)-2-(2,6-diamino-9H-purin-9-yl)-5-(hyd...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468709(CHEMBL4285647)
Affinity DataIC50:  2.87E+3nMAssay Description:Antagonist activity at smo in SAG-treated mouse Light2 cells after 48 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468720(CHEMBL4293248)
Affinity DataIC50:  3.48E+3nMAssay Description:Antagonist activity at smo in SAG-treated mouse Light2 cells after 48 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468708(CHEMBL4291101)
Affinity DataIC50:  3.61E+3nMAssay Description:Antagonist activity at smo in SAG-treated mouse Light2 cells after 48 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468711(CHEMBL4286606)
Affinity DataIC50:  3.72E+3nMAssay Description:Antagonist activity at smo in SAG-treated mouse Light2 cells after 48 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144934((2R,3R,4R,5R)-2-(6-hydroxy-9H-purin-9-yl)-5-(hydro...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetZinc finger protein GLI1(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468709(CHEMBL4285647)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of Gli1 transcriptional activity in mouse embroyonic fibroblasts after 24 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468715(CHEMBL4289866)
Affinity DataIC50:  6.92E+3nMAssay Description:Antagonist activity at smo in SAG-treated mouse Light2 cells after 48 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468706(CHEMBL4279181)
Affinity DataIC50:  6.97E+3nMAssay Description:Antagonist activity at smo in SAG-treated mouse Light2 cells after 48 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468716(CHEMBL4289632)
Affinity DataIC50:  1.05E+4nMAssay Description:Antagonist activity at smo in SAG-treated mouse Light2 cells after 48 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetZinc finger protein GLI1(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468706(CHEMBL4279181)
Affinity DataIC50:  1.07E+4nMAssay Description:Inhibition of Gli1 transcriptional activity in mouse embroyonic fibroblasts after 24 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetZinc finger protein GLI1(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468718(CHEMBL4290044)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of Gli1 transcriptional activity in mouse embroyonic fibroblasts after 24 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468712(CHEMBL4279361)
Affinity DataIC50:  1.60E+4nMAssay Description:Antagonist activity at smo in SAG-treated mouse Light2 cells after 48 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetZinc finger protein GLI1(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468711(CHEMBL4286606)
Affinity DataIC50:  1.71E+4nMAssay Description:Inhibition of Gli1 transcriptional activity in mouse embroyonic fibroblasts after 24 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetZinc finger protein GLI1(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468710(CHEMBL4281758)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Gli1 transcriptional activity in mouse embroyonic fibroblasts after 24 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50409930(CHEMBL2021379)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetZinc finger protein GLI1(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468708(CHEMBL4291101)
Affinity DataIC50:  2.12E+4nMAssay Description:Inhibition of Gli1 transcriptional activity in mouse embroyonic fibroblasts after 24 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144950(3'-deoxyadenosine | 9-(beta-D-3'-Deoxyribofuranosy...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetZinc finger protein GLI1(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468716(CHEMBL4289632)
Affinity DataIC50:  2.67E+4nMAssay Description:Inhibition of Gli1 transcriptional activity in mouse embroyonic fibroblasts after 24 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144933((2R,3S,4S,5R)-4-Fluoro-5-hydroxymethyl-2-(6-methyl...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468713(CHEMBL4293424)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at smo in SAG-treated mouse Light2 cells after 48 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468719(CHEMBL4278297)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at smo in SAG-treated mouse Light2 cells after 48 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468710(CHEMBL4281758)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at smo in SAG-treated mouse Light2 cells after 48 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468714(CHEMBL4282816)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at smo in SAG-treated mouse Light2 cells after 48 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468717(CHEMBL4286204)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at smo in SAG-treated mouse Light2 cells after 48 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetZinc finger protein GLI1(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468715(CHEMBL4289866)
Affinity DataIC50:  3.92E+4nMAssay Description:Inhibition of Gli1 transcriptional activity in mouse embroyonic fibroblasts after 24 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144939((2R,3R,4R,5R)-2-(2-amino-9H-purin-9-yl)-5-(hydroxy...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144945((2R,3R,4R,5R)-2-Hydroxymethyl-4-methoxy-5-(6-methy...)
Affinity DataIC50:  4.70E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144936(CHEMBL1090 | VIDARABINE | adenine arabinoside)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408410(CHEMBL480143)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144935((2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-3-ethyl-5-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50422565(CHEMBL2311161)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144932((2R,3R,4R,5R)-4-Fluoro-2-hydroxymethyl-5-(6-methyl...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144941((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxy...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144940((2R,3S,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxy...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetZinc finger protein GLI1(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468720(CHEMBL4293248)
Affinity DataIC50:  5.53E+4nMAssay Description:Inhibition of Gli1 transcriptional activity in mouse embroyonic fibroblasts after 24 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetZinc finger protein GLI1(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50468707(CHEMBL4290935)
Affinity DataIC50:  5.77E+4nMAssay Description:Inhibition of Gli1 transcriptional activity in mouse embroyonic fibroblasts after 24 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144932((2R,3R,4R,5R)-4-Fluoro-2-hydroxymethyl-5-(6-methyl...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144930(2-Amino-9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydr...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144933((2R,3S,4S,5R)-4-Fluoro-5-hydroxymethyl-2-(6-methyl...)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144936(CHEMBL1090 | VIDARABINE | adenine arabinoside)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144940((2R,3S,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxy...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144941((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxy...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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