Compile Data Set for Download or QSAR
maximum 50k data
Found 1984 with Last Name = 'berger' and Initial = 'w'
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345133((S)-1-((R)-5-chloro-3-(2-methoxy-5-(pyrrolidin-1-y...)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345134((S)-1-((R)-5-chloro-3-(2-methoxy-5-((4-methylpiper...)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345131((S)-1-((R)-5-chloro-3-(2-methoxy-4-((4-methylpiper...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345130((S)-1-((R)-5-chloro-3-(2-methoxy-4-(pyrrolidin-1-y...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175484(3-[2-(4-isoquinolin-8-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202351(US9238619, 70)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202348(US9238619, 67)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202356(US9238619, 73)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202353(US9238619, 72)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202341(US9238619, 63)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202337(US9238619, 62)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202336(US9238619, 61)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202335(US9238619, 60)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202334(US9238619, 59)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202316(US9238619, 52)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202315(US9238619, 51)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50100983(CHEMBL3326224)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202314(US9238619, 50)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202361(US9238619, 78)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202359(US9238619, 76)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202358(US9238619, 75)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202238(US9238619, 3)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202239(US9238619, 4)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202240(US9238619, 5)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202241(US9238619, 6)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202247(US9238619, 10)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202249(US9238619, 12)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202260(US9238619, 18)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202265(US9238619, 23)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202266(US9238619, 24)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202270(US9238619, 28)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202271(US9238619, 29)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202272(US9238619, 30)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202273(US9238619, 31)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202274(US9238619, 32)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202275(US9238619, 33)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM239934(US9403767, 117)
Affinity DataKi:  0.130nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
National Research Council of Canada

Curated by ChEMBL
LigandPNGBDBM50004744(CHEMBL2370453 | Hirudin analogue)
Affinity DataKi:  0.140nMAssay Description:Compound was evaluated for their ability to inhibit the alpha-thrombin-mediated hydrolysis of the fluorescent substrate Tos-Gly-Pro-Arg-AmcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50101099(CHEMBL3326228)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175479(7-methyl-3-[2-(4-quinolin-8-yl-piperazin-1-yl)-eth...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50101306(CHEMBL3326229)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]naloxone from human MOP receptor expressed in CHO-K1 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOpioid growth factor receptor-like protein 1(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM177911(US9120797, 10 | US9120797, 9)
Affinity DataKi:  0.260nM ΔG°:  -54.7kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345132((S)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulfonyl...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50100983(CHEMBL3326224)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]naloxone from human MOP receptor expressed in CHO-K1 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOpioid growth factor receptor-like protein 1(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM177903(US9120797, 1 | US9120797, 2 | US9120797, 3)
Affinity DataKi:  0.300nM ΔG°:  -54.4kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50101088(CHEMBL3326220)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]Naloxone from human mu opioid receptor receptor expressed in CHO-K1 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50100983(CHEMBL3326224)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175484(3-[2-(4-isoquinolin-8-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175479(7-methyl-3-[2-(4-quinolin-8-yl-piperazin-1-yl)-eth...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50316622((S)-methyl 4-(2-(3,4-dichlorophenyl)acetyl)-3-((S)...)
Affinity DataKi:  0.310nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig brain membrane after 150 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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