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Found 148 with Last Name = 'bergmeier' and Initial = 's'
TargetNeuronal acetylcholine receptor subunit alpha-10(Rattus norvegicus)
Ohio University

Curated by ChEMBL
LigandPNGBDBM50366779(METHYLLYCACONITINE)
Affinity DataKi:  1.30E+3nMAssay Description:Binding affinity towards alpha3-beta4 neuronal nicotinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of [3H]N-propylnorapomorphine as radioligand for Dopamine receptor D2 in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM7262(14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of human GSK-3beta incubated with substrate in presence of ATP measured by serial dilution assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM7262(14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of human GSK-3beta preincubated for 3 hrs followed by ATP and substrate addition measured by serial dilution assayMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataIC50:  27nMAssay Description:Inhibition of [3H]N-propylnorapomorphine binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50369323(MECAMYLAMINE)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against nicotinic acetylcholine receptor alpha3-beta4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50571206(CHEMBL4861930)
Affinity DataIC50:  102nMAssay Description:Inhibition of human GSK-3beta preincubated for 3 hrs followed by ATP and substrate addition measured by serial dilution assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | US20230414581, Co...)
Affinity DataIC50:  139nMAssay Description:Inhibition of human GSK-3beta preincubated for 3 hrs followed by ATP and substrate addition measured by serial dilution assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM81924((R)-3-(1-Propyl-piperidin-3-yl)-phenol | 3PPP(+/-)...)
Affinity DataIC50:  183nMAssay Description:Inhibition of [3H]N-propylnorapomorphine binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM81924((R)-3-(1-Propyl-piperidin-3-yl)-phenol | 3PPP(+/-)...)
Affinity DataIC50:  184nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50010580(4-(1-Allyl-1,2,5,6-tetrahydro-pyridin-3-yl)-thiazo...)
Affinity DataIC50:  257nMAssay Description:Inhibition of [3H]N-propylnorapomorphine binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50571206(CHEMBL4861930)
Affinity DataIC50:  370nMAssay Description:Inhibition of human GSK-3beta incubated with substrate in presence of ATP measured by serial dilution assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50571206(CHEMBL4861930)
Affinity DataIC50:  370nMAssay Description:Inhibition of human wild type GSK-3beta incubated with substrate in presence of ATP measured by serial dilution assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataIC50:  384nMAssay Description:Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determinedMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50010573(4-(1-Ethyl-1,2,5,6-tetrahydro-pyridin-3-yl)-thiazo...)
Affinity DataIC50:  411nMAssay Description:Inhibition of [3H]N-propylnorapomorphine binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50010580(4-(1-Allyl-1,2,5,6-tetrahydro-pyridin-3-yl)-thiazo...)
Affinity DataIC50:  440nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM81924((R)-3-(1-Propyl-piperidin-3-yl)-phenol | 3PPP(+/-)...)
Affinity DataIC50:  590nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50007573(4-(1-Propyl-1,2,5,6-tetrahydro-pyridin-3-yl)-thiaz...)
Affinity DataIC50:  596nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50129131(CHEBI:83275 | Hypothemycin | US10434085, Compound ...)
Affinity DataIC50:  663nMAssay Description:Inhibition of human GSK-3beta preincubated for 3 hrs followed by ATP and substrate addition measured by serial dilution assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50367946(CHEMBL1203001)
Affinity DataIC50:  911nMAssay Description:Inhibition of [3H]N-propylnorapomorphine binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM81924((R)-3-(1-Propyl-piperidin-3-yl)-phenol | 3PPP(+/-)...)
Affinity DataIC50:  930nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50010573(4-(1-Ethyl-1,2,5,6-tetrahydro-pyridin-3-yl)-thiazo...)
Affinity DataIC50:  945nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50007573(4-(1-Propyl-1,2,5,6-tetrahydro-pyridin-3-yl)-thiaz...)
Affinity DataIC50:  958nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50010571(CHEMBL108682 | Methyl-[4-(1-propyl-1,2,5,6-tetrahy...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes. (25% inhibition at 10 e-6 M)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50010575(5-(1-Propyl-1,2,5,6-tetrahydro-pyridin-3-yl)-3H-1l...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes. (2% inhibition at 10 e-6 M)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50367941(CHEMBL1203003)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes. (36%inhibition at 10 e-6 M)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50010571(CHEMBL108682 | Methyl-[4-(1-propyl-1,2,5,6-tetrahy...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of [3H]N-propylnorapomorphine binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50367938(CHEMBL1203009)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes. (15% inhibition at 10 e-6 M)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50367947(CHEMBL1203005)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes. (25% inhibition at 10 e-6 M)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50367942(CHEMBL1203006)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes. (41% inhibition at 10 e-6 M)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50367945(CHEMBL1203008)
Affinity DataIC50:  1.04E+3nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50367946(CHEMBL1203001)
Affinity DataIC50:  1.08E+3nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50451971(CHEMBL330867)
Affinity DataIC50:  1.20E+3nMAssay Description:Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50451972(CHEMBL125960)
Affinity DataIC50:  1.30E+3nMAssay Description:Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50451974(CHEMBL340342)
Affinity DataIC50:  1.30E+3nMAssay Description:Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50149051(2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoic ac...)
Affinity DataIC50:  1.30E+3nMAssay Description:Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50451977(CHEMBL122505)
Affinity DataIC50:  1.50E+3nMAssay Description:Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50419792(CHEMBL1950609)
Affinity DataIC50:  1.70E+3nMAssay Description:Antagonist activity at human nAChR alpha4/beta2 receptor expressed in HEK ts201 cells assessed as calcium accumulation by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50149040(Biphenyl-2-carboxylic acid 1-(3-phenyl-propyl)-pip...)
Affinity DataIC50:  1.70E+3nMAssay Description:Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50451973(CHEMBL332769)
Affinity DataIC50:  1.70E+3nMAssay Description:Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | US20230414581, Co...)
Affinity DataIC50:  1.78E+3nMAssay Description:Inhibition of human GSK-3beta incubated with substrate in presence of ATP measured by serial dilution assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50367943(CHEMBL1202201)
Affinity DataIC50:  1.85E+3nMAssay Description:Inhibition of [3H]N-propylnorapomorphine binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataIC50:  2.00E+3nMAssay Description:Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50367940(CHEMBL1203007)
Affinity DataIC50:  2.12E+3nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50367944(CHEMBL1203004)
Affinity DataIC50:  2.17E+3nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50419827(CHEMBL1950506)
Affinity DataIC50:  2.40E+3nMAssay Description:Antagonist activity at human nAChR alpha4/beta2 receptor expressed in HEK ts201 cells assessed as calcium accumulation by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50451978(CHEMBL334123)
Affinity DataIC50:  2.50E+3nMAssay Description:Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Ohio University

Curated by ChEMBL
LigandPNGBDBM50366779(METHYLLYCACONITINE)
Affinity DataIC50:  2.60E+3nMAssay Description:Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50367939(CHEMBL1203002)
Affinity DataIC50:  2.69E+3nMAssay Description:Inhibition of [3H]haloperidol binding for Dopamine receptor D2 in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50419851(CHEMBL1950510)
Affinity DataIC50:  2.82E+3nMAssay Description:Antagonist activity at human nAChR alpha4/beta2 receptor expressed in HEK ts201 cells assessed as calcium accumulation by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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