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Found 31 with Last Name = 'bernardo' and Initial = 'ph'
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50308110((S,Z)-2-(5-((6-(2,3-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKi:  3.40E+3nMAssay Description:Binding affinity to human Bcl-XL by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50308110((S,Z)-2-(5-((6-(2,3-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKi:  3.70E+3nMAssay Description:Displacement of fluorescein-labeled Bak-BH3 peptide from human Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKi:  8.70E+3nMAssay Description:Binding affinity to human Bcl-XL by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of fluorescein-labeled Bak-BH3 peptide from human Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50308111((S,Z)-2-(5-((6-(3,4-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of fluorescein-labeled Bak-BH3 peptide from human Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50308111((S,Z)-2-(5-((6-(3,4-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKi: >7.50E+5nMAssay Description:Binding affinity to human Bcl-XL by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25537(4-(2-hydroxyethyl)-8-methyl-12,14-dioxa-8-azatetra...)
Affinity DataIC50:  3.00E+3nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25539(4-(2-methoxyethyl)-8-methyl-12,14-dioxa-8-azatetra...)
Affinity DataIC50:  6.00E+3nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25536(4-(hydroxymethyl)-8-methyl-12,14-dioxa-8-azatetrac...)
Affinity DataIC50:  1.10E+4nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25538(4-(methoxymethyl)-8-methyl-12,14-dioxa-8-azatetrac...)
Affinity DataIC50:  1.10E+4nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25530(8-methyl-12,14-dioxa-8-azatetracyclo[8.7.0.0^{2,7}...)
Affinity DataIC50:  1.20E+4nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25540(7,8-dihydroxy-5-methylphenanthridin-5-ium chloride...)
Affinity DataIC50:  1.80E+4nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  1.90E+4nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25541(7,8-dihydroxy-2-(hydroxymethyl)-5-methylphenanthri...)
Affinity DataIC50:  2.00E+4nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25542(7,8-dihydroxy-2-(2-hydroxyethyl)-5-methylphenanthr...)
Affinity DataIC50:  2.20E+4nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25529(7,8-dimethoxy-5-methylphenanthridin-5-ium iodide |...)
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25535(2-(hydroxymethyl)-7,8-dimethoxy-5-methylphenanthri...)
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25534(13,13-dimethyl-8-oxido-12,14-dioxa-8-azatetracyclo...)
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25531(8,13,13-trimethyl-12,14-dioxa-8-azatetracyclo[8.7....)
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25532(7,8-dimethoxy-5-oxidophenanthridin-5-ium | chelery...)
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25533(8-oxido-12,14-dioxa-8-azatetracyclo[8.7.0.0^{2,7}....)
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25524(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Affinity DataIC50:  1.00E+5nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25526(7,8-dimethoxyphenanthridine | chelerythrine analog...)
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25527(12,14-dioxa-8-azatetracyclo[8.7.0.0^{2,7}.0^{11,15...)
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM25528(13,13-dimethyl-12,14-dioxa-8-azatetracyclo[8.7.0.0...)
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50308111((S,Z)-2-(5-((6-(3,4-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKd:  8.00E+3nMAssay Description:Displacement of fluorescein-labeled Bak-BH3 peptide from human Mcl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50308110((S,Z)-2-(5-((6-(2,3-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKd:  6.90E+3nMAssay Description:Displacement of fluorescein-labeled Bak-BH3 peptide from human Mcl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50308111((S,Z)-2-(5-((6-(3,4-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to human Mcl1 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKd:  8.40E+4nMAssay Description:Binding affinity to human Mcl1 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50308110((S,Z)-2-(5-((6-(2,3-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKd:  250nMAssay Description:Binding affinity to human Mcl1 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKd:  4.40E+4nMAssay Description:Displacement of fluorescein-labeled Bak-BH3 peptide from human Mcl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed