Found 239 with Last Name = 'bertamino' and Initial = 'a' 
Affinity DataKi: 7.30nM ΔG°: -46.4kJ/molepH: 7.4 T: 2°CAssay Description:CB1 competitive assay were performed in rat cerebellar membranes using [3H]WIN 55212-2 from Perkin-Elmer as a radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 8.40nM ΔG°: -46.1kJ/molepH: 7.4 T: 2°CAssay Description:CB1 competitive assay were performed in rat cerebellar membranes using [3H]WIN 55212-2 from Perkin-Elmer as a radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 15.7nM ΔG°: -44.5kJ/molepH: 7.4 T: 2°CAssay Description:CB1 competitive assay were performed in rat cerebellar membranes using [3H]WIN 55212-2 from Perkin-Elmer as a radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 24.1nM ΔG°: -43.5kJ/molepH: 7.4 T: 2°CAssay Description:CB1 competitive assay were performed in rat cerebellar membranes using [3H]WIN 55212-2 from Perkin-Elmer as a radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 42.6nM ΔG°: -42.1kJ/molepH: 7.4 T: 2°CAssay Description:CB1 competitive assay were performed in rat cerebellar membranes using [3H]WIN 55212-2 from Perkin-Elmer as a radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 49.4nM ΔG°: -41.7kJ/molepH: 7.4 T: 2°CAssay Description:CB1 competitive assay were performed in rat cerebellar membranes using [3H]WIN 55212-2 from Perkin-Elmer as a radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 69.6nM ΔG°: -40.9kJ/molepH: 7.4 T: 2°CAssay Description:CB1 competitive assay were performed in rat cerebellar membranes using [3H]WIN 55212-2 from Perkin-Elmer as a radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 74.6nM ΔG°: -40.7kJ/molepH: 7.4 T: 2°CAssay Description:CB1 competitive assay were performed in rat cerebellar membranes using [3H]WIN 55212-2 from Perkin-Elmer as a radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 311nM ΔG°: -37.1kJ/molepH: 7.4 T: 2°CAssay Description:CB1 competitive assay were performed in rat cerebellar membranes using [3H]WIN 55212-2 from Perkin-Elmer as a radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 390nM ΔG°: -36.6kJ/molepH: 7.4 T: 2°CAssay Description:CB1 competitive assay were performed in rat cerebellar membranes using [3H]WIN 55212-2 from Perkin-Elmer as a radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 553nM ΔG°: -35.7kJ/molepH: 7.4 T: 2°CAssay Description:CB1 competitive assay were performed in rat cerebellar membranes using [3H]WIN 55212-2 from Perkin-Elmer as a radioligand.More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced channel currents by whole cell patch clamp methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced channel currents by whole cell patch clamp methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 4.10nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 6.60nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 7.70nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
University Of Naples Federico Ii
Curated by ChEMBL
University Of Naples Federico Ii
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
University Of Naples Federico Ii
Curated by ChEMBL
University Of Naples Federico Ii
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
University Of Naples Federico Ii
Curated by ChEMBL
University Of Naples Federico Ii
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of menthol-induced calcium currents at -60 mV measured fo...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of menthol-induced calcium currents at -60 mV measured fo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of menthol-induced calcium currents at -60 mV measured fo...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
University Of Palermo
Curated by ChEMBL
University Of Palermo
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of GLS-1 (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Inhibition of GRK-2 (unknown origin)-mediated phosphorylation of rhodopsin in bovine-rod outer segment membranes incubated under white light conditio...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 367nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol mediated current amplitude at +80 mV holding potential b...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 475nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol mediated current amplitude at +80 mV holding potential b...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 475nMAssay Description:Antagonist activity at TRPM8 (unknown origin) assessed as reduction in menthol-induced calcium influxMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 490nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
