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Found 758 with Last Name = 'bertrand' and Initial = 'j'
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427698(CHEMBL2324206)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427703(CHEMBL2324220)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427703(CHEMBL2324220)
Affinity DataKi:  22nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427697(CHEMBL2324207)
Affinity DataKi:  23nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427696(CHEMBL2324201)
Affinity DataKi:  26nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427703(CHEMBL2324220)
Affinity DataKi:  38nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427698(CHEMBL2324206)
Affinity DataKi:  44nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427700(CHEMBL2324204)
Affinity DataKi:  50nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427696(CHEMBL2324201)
Affinity DataKi:  70nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427713(CHEMBL2324209)
Affinity DataKi:  73nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427715(CHEMBL2324219)
Affinity DataKi:  78nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427699(CHEMBL2324205)
Affinity DataKi:  85nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427701(CHEMBL2324203)
Affinity DataKi:  87nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427702(CHEMBL2324202)
Affinity DataKi:  103nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427701(CHEMBL2324203)
Affinity DataKi:  107nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427697(CHEMBL2324207)
Affinity DataKi:  171nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427700(CHEMBL2324204)
Affinity DataKi:  228nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427697(CHEMBL2324207)
Affinity DataKi:  246nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427696(CHEMBL2324201)
Affinity DataKi:  275nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427699(CHEMBL2324205)
Affinity DataKi:  365nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427698(CHEMBL2324206)
Affinity DataKi:  410nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427709(CHEMBL2324213)
Affinity DataKi:  498nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427699(CHEMBL2324205)
Affinity DataKi:  833nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427702(CHEMBL2324202)
Affinity DataKi:  927nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427714(CHEMBL2324208)
Affinity DataKi:  1.15E+3nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427701(CHEMBL2324203)
Affinity DataKi:  1.28E+3nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427702(CHEMBL2324202)
Affinity DataKi:  1.89E+3nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427700(CHEMBL2324204)
Affinity DataKi:  3.26E+3nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427704(CHEMBL2324218)
Affinity DataKi:  5.28E+3nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427708(CHEMBL2324214)
Affinity DataKi:  7.02E+3nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427710(CHEMBL2324212)
Affinity DataKi:  7.75E+3nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427711(CHEMBL2324211)
Affinity DataKi:  1.80E+4nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427706(CHEMBL2324216)
Affinity DataKi: >3.30E+4nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427712(CHEMBL2324210)
Affinity DataKi: >3.30E+4nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427707(CHEMBL2324215)
Affinity DataKi: >3.30E+4nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427705(CHEMBL2324217)
Affinity DataKi: >3.30E+4nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50069316(CHEMBL3403549 | US9688661, 1-[2-Chloro-5-(trifluor...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50069322(CHEMBL3403545)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50069326(CHEMBL3403541 | US9688661, 1-(5-Chloro-2-methylphe...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50497782(CHEMBL3330130)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human JAK2 (808-1132 residues) using LPLDKDYYVVREPGQ as substrate by radiometric assay in presence of [33P]-gamma-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Technical University Dortmund

Curated by ChEMBL
LigandPNGBDBM50543600(CHEMBL4639853)
Affinity DataIC50:  2nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50318085(1-Methyl-8-[(2-methylphenyl)amino]-4,5-dihydro-1H-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Plk2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM31532(pyrazolo[4,3-h]quinazoline-3-carboxamide, 1)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK2/Cyclin A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50318087(8-(Phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quin...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK2/Cyclin A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27359(7-ethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,...)
Affinity DataIC50:  2nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27362(7-(2-fluoroethyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-...)
Affinity DataIC50:  2nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27371(2-(2-aminopyrimidin-4-yl)-7,7-dimethyl-1H,4H,5H,6H...)
Affinity DataIC50:  2nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27380((7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1...)
Affinity DataIC50:  2nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50318089(8-[(4-Acetylphenyl)amino]-1-methyl-4,5-dihydro-1H-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK2/Cyclin A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50318088(8-[(3-Acetylphenyl)amino]-1-methyl-4,5-dihydro-1H-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK2/Cyclin A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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