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Found 23 with Last Name = 'bhagwat' and Initial = 'sv'
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339059(3-cyclobutyl-1-(2-phenylquinolin-7-yl)-imidazo[1,5...)
Affinity DataIC50:  80nMAssay Description:Inhibition of IGF-1R by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(CHEMBL1762110 | Trans-N-((-4-(8-amino-1-(1H-indol-...)
Affinity DataIC50:  180nMAssay Description:Inhibition of cRafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50199683(3-(8-amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)...)
Affinity DataIC50:  520nMAssay Description:Inhibition of IGF-1R by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50:  770nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(CHEMBL1762110 | Trans-N-((-4-(8-amino-1-(1H-indol-...)
Affinity DataIC50:  960nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of cRafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(CHEMBL1762110 | Trans-N-((-4-(8-amino-1-(1H-indol-...)
Affinity DataIC50:  1.96E+3nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(CHEMBL1762110 | Trans-N-((-4-(8-amino-1-(1H-indol-...)
Affinity DataIC50:  2.72E+3nMAssay Description:Inhibition of IGF-1R by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(CHEMBL1762110 | Trans-N-((-4-(8-amino-1-(1H-indol-...)
Affinity DataIC50:  3.58E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(CHEMBL1762110 | Trans-N-((-4-(8-amino-1-(1H-indol-...)
Affinity DataIC50:  4.21E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(CHEMBL1762110 | Trans-N-((-4-(8-amino-1-(1H-indol-...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340953(3-cyclobutyl-1-(quinolin-7-yl)imidazo[1,5-a]pyrazi...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IGF-1R by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(CHEMBL1762110 | Trans-N-((-4-(8-amino-1-(1H-indol-...)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(CHEMBL1762110 | Trans-N-((-4-(8-amino-1-(1H-indol-...)
Affinity DataIC50:  2.26E+4nMAssay Description:Inhibition of IRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of IGF-1R by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of IRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(CHEMBL1762110 | Trans-N-((-4-(8-amino-1-(1H-indol-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed