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Found 87 with Last Name = 'bianchini' and Initial = 'f'
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50523895(CHEMBL4522121)
Affinity DataIC50:  0.0480nMAssay Description:Inhibition of MMP2 (unknown origin) pre-incubated for 5 mins before Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50523894(CHEMBL4535400)
Affinity DataIC50:  0.0960nMAssay Description:Inhibition of MMP2 (unknown origin) pre-incubated for 5 mins before Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50523894(CHEMBL4535400)
Affinity DataIC50:  0.122nMAssay Description:Inhibition of MMP9 (unknown origin) pre-incubated for 5 mins before Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50523891(CHEMBL4461597)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of MMP2 (unknown origin) pre-incubated for 5 mins before Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50523890(CHEMBL4444377)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of MMP2 (unknown origin) pre-incubated for 5 mins before Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50235980(2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-...)
Affinity DataIC50:  0.400nMAssay Description:Binding affinity to integrin alphav/beta3 heterodimer in human M21 cells assessed as inhibition of integrin-mediated human M21 cell adhesion to vitro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50523891(CHEMBL4461597)
Affinity DataIC50:  0.760nMAssay Description:Inhibition of MMP9 (unknown origin) pre-incubated for 5 mins before Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50523890(CHEMBL4444377)
Affinity DataIC50:  0.910nMAssay Description:Inhibition of MMP9 (unknown origin) pre-incubated for 5 mins before Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50233956(CHEMBL4075011)
Affinity DataIC50:  1.20nMAssay Description:Displacement of biotinylated vitronectin from recombinant human integrin alphaVbeta3 dark incubated for 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PDGFRbeta (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50523897(CHEMBL4531635)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of MMP2 (unknown origin) pre-incubated for 5 mins before Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50140178(CHEMBL3754350)
Affinity DataIC50:  2.40nMAssay Description:Binding affinity to integrin alphav/beta3 heterodimer in human M21 cells assessed as inhibition of integrin-mediated human M21 cell adhesion to vitro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50237601(CHEMBL411941 | CycloRGDfV | [(2S,5R,8S,11S)-5-Benz...)
Affinity DataIC50:  3.20nMAssay Description:Displacement of biotinylated vitronectin from human integrin alphaVbeta3 measured after 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50233954(CHEMBL4066412)
Affinity DataIC50:  3.80nMAssay Description:Displacement of biotinylated vitronectin from recombinant human integrin alphaVbeta3 dark incubated for 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50233955(CHEMBL4095441)
Affinity DataIC50:  5.10nMAssay Description:Displacement of biotinylated vitronectin from recombinant human integrin alphaVbeta3 dark incubated for 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50233958(CHEMBL4087743)
Affinity DataIC50:  6.10nMAssay Description:Displacement of biotinylated vitronectin from human integrin alphaVbeta3 measured after 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50276747(CHEMBL443362 | c[RGDf-(3R)-Carboxymorpholine])
Affinity DataIC50:  6.5nMAssay Description:Displacement of [125I] echistatin from alphaVbeta3 integrin isolated from human placenta after 3 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50523896(CHEMBL4585478)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of MMP2 (unknown origin) pre-incubated for 5 mins before Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233954(CHEMBL4066412)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant human PDGFRbeta expressed in insect cells using Ulight-Poly GAT[EAY(1:1:1)]n as substrate measured after 30 mins by LANCE m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50140179(CHEMBL3753748)
Affinity DataIC50:  15nMAssay Description:Binding affinity to integrin alpha5/beta1 heterodimer in human K562 cells assessed as inhibition of integrin-mediated human K562 cell adhesion to fib...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50140177(CHEMBL3752070)
Affinity DataIC50:  20nMAssay Description:Binding affinity to integrin alphav/beta3 heterodimer (unknown origin) assessed as inhibition of integrin-mediated cell adhesion to vitronectinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50523893(CHEMBL4448558)
Affinity DataIC50:  21nMAssay Description:Inhibition of MMP2 (unknown origin) pre-incubated for 5 mins before Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50523896(CHEMBL4585478)
Affinity DataIC50:  22nMAssay Description:Inhibition of MMP9 (unknown origin) pre-incubated for 5 mins before Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50140178(CHEMBL3754350)
Affinity DataIC50:  26nMAssay Description:Binding affinity to integrin alpha5/beta1 heterodimer in human K562 cells assessed as inhibition of integrin-mediated human K562 cell adhesion to fib...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50233956(CHEMBL4075011)
Affinity DataIC50:  31nMAssay Description:Displacement of biotinylated fibronectin from recombinant human integrin alpha5beta1 dark incubated for 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50140179(CHEMBL3753748)
Affinity DataIC50:  34nMAssay Description:Binding affinity to integrin alphav/beta3 heterodimer in human M21 cells assessed as inhibition of integrin-mediated human M21 cell adhesion to vitro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50523895(CHEMBL4522121)
Affinity DataIC50:  35nMAssay Description:Inhibition of MMP9 (unknown origin) pre-incubated for 5 mins before Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50523893(CHEMBL4448558)
Affinity DataIC50:  47nMAssay Description:Inhibition of MMP9 (unknown origin) pre-incubated for 5 mins before Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50389204(CHEMBL2062977)
Affinity DataIC50:  48nMAssay Description:Displacement of [125I] echistatin from alphaVbeta3 integrin isolated from human placenta after 3 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  80nMAssay Description:Inhibition of VEGFR2 (unknown origin) phosphorylationMore data for this Ligand-Target Pair
TargetLegumain(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50600333(CHEMBL5183094)
Affinity DataIC50:  89nMAssay Description:Inhibition of recombinant human Asparagine endopeptidase preincubated for 5 mins followed by Z-Ala-Ala-Asn-AMC substrate addition measured after 2 hr...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50233954(CHEMBL4066412)
Affinity DataIC50:  96nMAssay Description:Displacement of biotinylated fibronectin from recombinant human integrin alpha5beta1 dark incubated for 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50233955(CHEMBL4095441)
Affinity DataIC50:  101nMAssay Description:Displacement of biotinylated fibronectin from recombinant human integrin alpha5beta1 dark incubated for 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50585538(CHEMBL5087579)
Affinity DataIC50:  120nMAssay Description:Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to vitronectin in human A549 cells preincubated for 30 mins followed by VN substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50233958(CHEMBL4087743)
Affinity DataIC50:  152nMAssay Description:Inhibition of alpha5beta1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50585538(CHEMBL5087579)
Affinity DataIC50:  210nMAssay Description:Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to vitronectin in human WM 266-4 cells preincubated for 30 mins followed by VN sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233958(CHEMBL4087743)
Affinity DataIC50:  315nMAssay Description:Displacement of biotinylated vitronectin from human integrin alphaVbeta5 measured after 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50233954(CHEMBL4066412)
Affinity DataIC50:  420nMAssay Description:Inhibition of recombinant human VEGFR2 expressed in Sf9 cells using Ulight-CAGAGAIETDKEYYTVKD as substrate measured after 60 mins by LANCE methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50523892(CHEMBL4531703)
Affinity DataIC50:  492nMAssay Description:Inhibition of MMP2 (unknown origin) pre-incubated for 5 mins before Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50600329(CHEMBL5197937)
Affinity DataIC50:  498nMAssay Description:Inhibition of recombinant human Asparagine endopeptidase preincubated for 5 mins followed by Z-Ala-Ala-Asn-AMC substrate addition measured after 2 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50233954(CHEMBL4066412)
Affinity DataIC50:  500nMAssay Description:Inhibition of vitronectin binding to alphaVbeta3 in human EPC in presence of MnCl2 measured after 30 mins by crystal violet staining based cell adhes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50233956(CHEMBL4075011)
Affinity DataIC50:  500nMAssay Description:Inhibition of vitronectin binding to alphaVbeta3 in human EPC in presence of MnCl2 measured after 30 mins by crystal violet staining based cell adhes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50523897(CHEMBL4531635)
Affinity DataIC50:  520nMAssay Description:Inhibition of MMP9 (unknown origin) pre-incubated for 5 mins before Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50600332(CHEMBL5194542)
Affinity DataIC50:  547nMAssay Description:Inhibition of recombinant human Asparagine endopeptidase preincubated for 5 mins followed by Z-Ala-Ala-Asn-AMC substrate addition measured after 2 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLegumain(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50600334(CHEMBL5175987)
Affinity DataIC50:  757nMAssay Description:Inhibition of recombinant human Asparagine endopeptidase preincubated for 5 mins followed by Z-Ala-Ala-Asn-AMC substrate addition measured after 2 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLegumain(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50600328(CHEMBL5185780)
Affinity DataIC50:  844nMAssay Description:Inhibition of recombinant human Asparagine endopeptidase preincubated for 5 mins followed by Z-Ala-Ala-Asn-AMC substrate addition measured after 2 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327751((S)-3-{2-[4-(3-Guanidinopropyl)[1,2,3]triazol-1-yl...)
Affinity DataIC50:  1.02E+3nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50327755((S)-3-(2-{4-[2-(4-Carbamimidoylpiperazin-1-yl)ethy...)
Affinity DataIC50:  1.27E+3nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50327751((S)-3-{2-[4-(3-Guanidinopropyl)[1,2,3]triazol-1-yl...)
Affinity DataIC50:  1.35E+3nMAssay Description:Displacement of [125I]echistatin from human integrin alphaVbeta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50390492(CHEMBL2071605)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to vitronectin in human WM 266-4 cells preincubated for 30 mins followed by VN sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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