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Found 40 with Last Name = 'bikker' and Initial = 'ja'
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277145((+/-)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)...)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277131((+/-)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)...)
Affinity DataKi:  7.40nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277180(4-(1-(2-(5-chloro-1H-indol-3-yl)ethyl)piperidin-3-...)
Affinity DataKi:  10.4nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277146((+)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N...)
Affinity DataKi:  11.2nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277146((+)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N...)
Affinity DataKi:  11.2nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50001859((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277130((+/-)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)...)
Affinity DataKi:  21.3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277147(CHEMBL473903 | N-cyclopropyl-4-(1-(2-(5-fluoro-1H-...)
Affinity DataKi:  23.6nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277181(4-(1-(2-(5-chloro-2-methyl-1H-indol-3-yl)ethyl)pip...)
Affinity DataKi:  26.6nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277144((+/-)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277182(CHEMBL475694 | N-cyclopropyl-4-(1-(2-(7-fluoro-1H-...)
Affinity DataKi:  35.1nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277184(CHEMBL474282 | N-cyclopropyl-4-(1-(2-((S)-2,3-dihy...)
Affinity DataKi:  37.8nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277210(4-(1-(2-(benzo[b]thiophen-3-yl)ethyl)piperidin-3-y...)
Affinity DataKi:  38.5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277212(4-(1-(1-(1H-indol-3-yl)propan-2-yl)piperidin-3-yl)...)
Affinity DataKi:  40.2nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277211(CHEMBL475090 | N-cyclopropyl-4-(1-(2-(2,3-dihydro-...)
Affinity DataKi:  42.5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277183(CHEMBL514010 | N-cyclopropyl-4-(1-(2-(6-fluoro-1H-...)
Affinity DataKi:  64.5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277252(4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N-(2-...)
Affinity DataKi:  66.3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277129((+/-)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)...)
Affinity DataKi:  75.3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277251(4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N-(3-...)
Affinity DataKi:  78.3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277250(3-(4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)pyr...)
Affinity DataKi:  175nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277214(CHEMBL475092 | N-cyclopropyl-4-(1-(2-(thiazol-4-yl...)
Affinity DataKi:  780nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277213(2-(3-(2-(cyclopropylamino)pyrimidin-4-yl)piperidin...)
Affinity DataKi:  3.42E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277249(4-(1-(2-(1H-pyrazol-4-yl)ethyl)piperidin-3-yl)-N-c...)
Affinity DataKi:  4.45E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Parke-Davis Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50085561(4-[2-(3-{2-[2-(3-Hydroxy-phenyl)-ethyl]-benzyloxy}...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of N-type calcium channel (VSCC) in IMR-32 at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Parke-Davis Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50085561(4-[2-(3-{2-[2-(3-Hydroxy-phenyl)-ethyl]-benzyloxy}...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of L-type [Ca2+] channel (VSCC) in rat A7r5 vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Parke-Davis Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50085560(4-[2-(3-{2-[2-(4-Hydroxy-phenyl)-ethyl]-benzyloxy}...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of N-type calcium channel (VSCC) in IMR-32 at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Parke-Davis Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50085560(4-[2-(3-{2-[2-(4-Hydroxy-phenyl)-ethyl]-benzyloxy}...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of L-type [Ca2+] channel (VSCC) in rat A7r5 vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277146((+)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N...)
Affinity DataEC50:  302nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277146((+)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N...)
Affinity DataEC50:  302nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277147(CHEMBL473903 | N-cyclopropyl-4-(1-(2-(5-fluoro-1H-...)
Affinity DataEC50:  169nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277182(CHEMBL475694 | N-cyclopropyl-4-(1-(2-(7-fluoro-1H-...)
Affinity DataEC50:  216nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277211(CHEMBL475090 | N-cyclopropyl-4-(1-(2-(2,3-dihydro-...)
Affinity DataEC50:  290nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277250(3-(4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)pyr...)
Affinity DataEC50:  51.4nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277251(4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N-(3-...)
Affinity DataEC50:  65nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277252(4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N-(2-...)
Affinity DataEC50:  40.7nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataKd:  35.3nMAssay Description:Binding affinity to wild type EGFR (unknown origin)More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277131((+/-)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)...)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277130((+/-)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)...)
Affinity DataEC50:  147nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277129((+/-)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)...)
Affinity DataEC50:  138nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50001859((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Affinity DataEC50:  41nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed