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Found 44 with Last Name = 'biorn' and Initial = 'c'
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM31592(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine from PDE10A in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50365964(CHEMBL1956235 | CHEMBL2070530)
Affinity DataKi:  1.18nMAssay Description:Displacement of [3H]5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine from PDE10A in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021130(CHEMBL3287658)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM31592(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [3H]5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine from PDE10A in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
LigandPNGBDBM50389801(CHEMBL2070528)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021260(CHEMBL3287907)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM50003992(CHEMBL2180803)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50494203(CHEMBL3086098)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50365964(CHEMBL1956235 | CHEMBL2070530)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021256(CHEMBL3287905)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM50494204(CHEMBL3086100)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50021259(CHEMBL3287906)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50365964(CHEMBL1956235 | CHEMBL2070530)
Affinity DataIC50:  3.47nMAssay Description:Displacement of [3H]5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine from PDE10A in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021188(CHEMBL3287662)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM50494195(CHEMBL3086097)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50494200(CHEMBL3086088)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50494199(CHEMBL3086091)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50494191(CHEMBL3086094)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50494193(CHEMBL3086099)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50021131(CHEMBL3287659)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389800(CHEMBL2070529)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021251(CHEMBL3287903)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50494196(CHEMBL3086096)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50494205(CHEMBL3086093)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50494202(CHEMBL3086086)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50494198(CHEMBL3086092)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50021128(CHEMBL3287657)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021250(CHEMBL3287902)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50494197(CHEMBL3086095)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50021194(CHEMBL3287900)
Affinity DataIC50:  22nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50494194(CHEMBL3086101)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50021192(CHEMBL3287665)
Affinity DataIC50:  37nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM115297(US8637500, 106)
Affinity DataIC50:  37nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021168(CHEMBL3287661)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50494201(CHEMBL3086087)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50021249(CHEMBL3287901)
Affinity DataIC50:  47nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021193(CHEMBL3287899)
Affinity DataIC50:  52nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021191(CHEMBL3287664)
Affinity DataIC50:  105nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021162(CHEMBL3287660)
Affinity DataIC50:  115nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50494192(CHEMBL3086090)
Affinity DataIC50:  168nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate preincubated for 30 mins prior to substrate addition measured after 1 hr by IMAP TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50021252(CHEMBL3287904)
Affinity DataIC50:  271nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021190(CHEMBL3287663)
Affinity DataIC50:  404nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365964(CHEMBL1956235 | CHEMBL2070530)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to human truncated CM5-labeled PDE10A by surface plasmon resonance methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50365964(CHEMBL1956235 | CHEMBL2070530)
Affinity DataKd:  0.940nMAssay Description:Binding affinity to PDE10A in Sprague-Dawley rat striatum by TopCount analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed