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Found 33 with Last Name = 'biot' and Initial = 'c'
TargetGlutathione reductase(Plasmodium falciparum (isolate 3D7))
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibitory concentration against Plasmodium falciparum glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialin(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM50545752(CHEMBL4646356)
Affinity DataKi:  7.80E+3nMAssay Description:Non-competitive inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake incubated for 15 mins by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSialin(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM115093((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-met...)
Affinity DataKi:  1.02E+4nMAssay Description:Non-competitive inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake incubated for 15 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM24778(2-methyl-1,4-dihydronaphthalene-1,4-dione | 2-meth...)
Affinity DataKi:  1.21E+4nMAssay Description:Inhibitory concentration against human glutathione reductase (In presence of glutathione disulfide)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM24778(2-methyl-1,4-dihydronaphthalene-1,4-dione | 2-meth...)
Affinity DataKi:  1.61E+4nMAssay Description:Inhibitory concentration against human glutathione reductase (In presence of NADPH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialin(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM50286804((R)-2-[(R)-2-{(S)-2-[(Azepane-1-carbonyl)-amino]-4...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake at 30 to 300 uM incubated for 15 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096035(6-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  750nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096062(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096035(6-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  1.30E+3nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialin(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM50545752(CHEMBL4646356)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake at 30 to 300 uM incubated for 15 mins by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096062(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  2.50E+3nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  2.60E+3nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory concentration against human glutathione reductase in the the presence of 200 uM exogenous NADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096071(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  2.70E+3nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory concentration against human glutathione reductase in the the presence of 200 uM exogenous NADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory concentration against human glutathione reductase in the absence of glucose-6-phosphate dehydrogenase (G6PDH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096071(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  4.00E+3nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFalcipain 2(Plasmodium falciparum)
Université

Curated by ChEMBL
LigandPNGBDBM50225295((E)-4-(2-(7-chloroquinolin-4-ylamino)ethyl)-1-(4-(...)
Affinity DataIC50:  4.42E+3nMAssay Description:Inhibition of Plasmodium falciparum W2 recombinant falcipain-2 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase(Plasmodium falciparum (isolate 3D7))
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibitory concentration against Plasmodium falciparum glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase(Plasmodium falciparum (isolate 3D7))
Université

Curated by ChEMBL
LigandPNGBDBM50241461(3,7-bis(dimethylamino)phenothiazin-5-ium chloride ...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibitory concentration against Plasmodium falciparum glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase(Plasmodium falciparum (isolate 3D7))
Université

Curated by ChEMBL
LigandPNGBDBM50156159(3-{5-[4-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen...)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibitory concentration against Plasmodium falciparum glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFalcipain 2(Plasmodium falciparum)
Université

Curated by ChEMBL
LigandPNGBDBM50225297((E)-1-(4-(4-bromophenyl)-4-oxobutan-2-ylidene)-4-(...)
Affinity DataIC50:  1.29E+4nMAssay Description:Inhibition of Plasmodium falciparum W2 recombinant falcipain-2 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50241461(3,7-bis(dimethylamino)phenothiazin-5-ium chloride ...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFalcipain 2(Plasmodium falciparum)
Université

Curated by ChEMBL
LigandPNGBDBM50225296((E)-1-(4-(4-bromophenyl)-4-oxobutan-2-ylidene)-4-(...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Plasmodium falciparum W2 recombinant falcipain-2 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFalcipain 2(Plasmodium falciparum)
Université

Curated by ChEMBL
LigandPNGBDBM50225298((E)-4-(3-(7-chloroquinolin-4-ylamino)propyl)-1-(4-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Plasmodium falciparum W2 recombinant falcipain-2 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50156161(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  2.27E+4nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialin(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM115093((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-met...)
Affinity DataIC50:  2.33E+4nMAssay Description:Inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake at 30 to 300 uM incubated for 15 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50156159(3-{5-[4-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Unit£

Curated by ChEMBL
LigandPNGBDBM22985(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
Affinity DataIC50:  4.63E+4nMAssay Description:Inhibition of lipid-induced beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase(Plasmodium falciparum (isolate 3D7))
Université

Curated by ChEMBL
LigandPNGBDBM50156161(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  5.70E+4nMAssay Description:Inhibitory concentration against Plasmodium falciparum glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed