Compile Data Set for Download or QSAR
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Found 655 with Last Name = 'black' and Initial = 'r'
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6....)
Affinity DataKi:  0.00100nMAssay Description:Inhibition of recombinant JAK2Checked by AuthorMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6....)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of recombinant JAK3Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6....)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of recombinant JAK3Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6....)
Affinity DataKi:  17nMAssay Description:Inhibition of ALKChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345085((2S)-N-(3-(1-aminoisoquinolin-6-yl)-1-oxo-1-(piper...)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345082(1-(1,4-diazepan-1-yl)-2-(5-methoxy-1-(4-methoxy-2,...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6....)
Affinity DataKi:  190nMAssay Description:Inhibition of cKitChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345068((1,4-diazepan-1-yl)(5-methoxy-1-(4-methoxy-2,3-dim...)
Affinity DataKi:  190nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345071((S)-2-(4-methoxy-2,3,6-trimethylphenylsulfonamido)...)
Affinity DataKi:  250nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300198(5-chloro-3-phenyl-1H-pyrrolo[2,3-b]pyridine | CHEM...)
Affinity DataKi:  260nMAssay Description:Inhibition of recombinant JAK2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345084(2-(5-fluoro-1-(4-methoxy-2,3-dimethylphenylsulfony...)
Affinity DataKi:  260nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345081((1,4-diazepan-1-yl)(5-fluoro-1-(4-methoxy-2,3-dime...)
Affinity DataKi:  310nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345082(1-(1,4-diazepan-1-yl)-2-(5-methoxy-1-(4-methoxy-2,...)
Affinity DataKi:  320nMAssay Description:Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6....)
Affinity DataKi:  340nMAssay Description:Inhibition of GCKChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345083(2-(5-fluoro-1-(4-methoxy-2,3-dimethylphenylsulfony...)
Affinity DataKi:  430nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300197(4-phenyl-7H-pyrrolo[2,3-d]pyrimidine | CHEMBL57897...)
Affinity DataKi:  480nMAssay Description:Inhibition of recombinant JAK2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345079((1-(4-methoxy-2,3-dimethylphenylsulfonyl)-2-methyl...)
Affinity DataKi:  500nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345070((S)-2-(4-methoxy-2,3,6-trimethylphenylsulfonamido)...)
Affinity DataKi:  500nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345078(1-(4-methoxy-2,3-dimethylphenylsulfonyl)-2-methyl-...)
Affinity DataKi:  560nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345069((S)-2-(4-methoxy-2,3,6-trimethylphenylsulfonamido)...)
Affinity DataKi:  630nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345080((1,4-diazepan-1-yl)(1-(4-methoxy-2,3-dimethylpheny...)
Affinity DataKi:  790nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345075((S)-2-(4-methoxy-2,3,6-trimethylphenylsulfonamido)...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345077(1-(4-methoxy-2,3-dimethylphenylsulfonyl)-N-(3-(4-m...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345074((S)-N-(3-(dimethylamino)propyl)-2-(4-methoxy-2,3,6...)
Affinity DataKi:  2.00E+3nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345072((S)-2-(4-methoxy-2,3,6-trimethylphenylsulfonamido)...)
Affinity DataKi:  2.50E+3nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345076((S)-4-methoxy-2,3,6-trimethyl-N-(1-(4-methyl-1,4-d...)
Affinity DataKi:  3.20E+3nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345066((S)-2-(4-methoxy-2,3,6-trimethylphenylsulfonamido)...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345065((S)-2-(4-methoxy-2,3,6-trimethylphenylsulfonamido)...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345067((S)-2-(4-methoxy-2,3,6-trimethylphenylsulfonamido)...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345068((1,4-diazepan-1-yl)(5-methoxy-1-(4-methoxy-2,3-dim...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1A receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345068((1,4-diazepan-1-yl)(5-methoxy-1-(4-methoxy-2,3-dim...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345073((S)-2-(4-methoxy-2,3,6-trimethylphenylsulfonamido)...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]-AVP from human vasopressin V1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50345068((1,4-diazepan-1-yl)(5-methoxy-1-(4-methoxy-2,3-dim...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50106133(5-Bromo-2-{[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Affinity DataIC50:  0.5nMAssay Description:In vitro inhibition of Matrix metalloprotease-9.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50106133(5-Bromo-2-{[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50106136(2-{[4-(4-Chloro-phenoxy)-benzenesulfonyl]-methyl-a...)
Affinity DataIC50:  0.800nMAssay Description:In vitro inhibition of Matrix metalloprotease-13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50126626(4-{Methyl-[4-(pyridin-4-yloxy)-benzenesulfonyl]-am...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 9 (MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50106136(2-{[4-(4-Chloro-phenoxy)-benzenesulfonyl]-methyl-a...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of Matrix metalloprotease-9.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50126600(1,3-Dimethyl-4-{methyl-[4-(pyridin-4-yloxy)-benzen...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 13 (MMP-13).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50126624(8-Bromo-4-[(4-methoxy-benzenesulfonyl)-pyridin-3-y...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 13 (MMP-13).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50126620(4-[(4-Methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 13 (MMP-13).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50126623(8-Methoxy-4-[(4-methoxy-benzenesulfonyl)-pyridin-3...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 13 (MMP-13).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50126626(4-{Methyl-[4-(pyridin-4-yloxy)-benzenesulfonyl]-am...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 13 (MMP-13).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50126622(4-(N-benzyl-4-methoxyphenylsulfonamido)-N-hydroxy-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 13 (MMP-13).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50126612(4-{[4-(4-Chloro-phenoxy)-benzenesulfonyl]-methyl-a...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against matrix metalloproteinase 13 (MMP-13).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157926(2-{3-[1-(4-Methoxy-benzoyl)-2-methyl-5-trifluorome...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157917((2S)-2-(3-{[1-(4-METHOXYBENZOYL)-2-METHYL-5-(TRIFL...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157931(2-{2-[1-(4-Methoxy-benzoyl)-2-methyl-5-trifluorome...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157933(2-{2-[1-(4-Methoxy-benzoyl)-2-methyl-5-trifluorome...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50166300((S)-2-{2-Chloro-5-[1-(6-chloro-benzo[d]isoxazol-3-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human peroxisome proliferator activated receptor gamma bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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