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Found 71 with Last Name = 'blackburn' and Initial = 'k'
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27542(4-(3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056588((S)-3-[1-tert-Butyl-7-(4-carbamimidoyl-phenylethyn...)
Affinity DataIC50:  2nMAssay Description:Binding affinity for soluble GPIIb/IIIa captured on fibrinogen coated microtiter plateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056588((S)-3-[1-tert-Butyl-7-(4-carbamimidoyl-phenylethyn...)
Affinity DataIC50:  2nMAssay Description:Binding affinity for soluble GPIIb/IIIa captured on fibrinogen coated microtiter plateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056589((S)-3-[1-tert-Butyl-7-(4-carbamimidoyl-phenylethyn...)
Affinity DataIC50:  3nMAssay Description:Binding affinity for soluble GPIIb/IIIa captured on fibrinogen coated microtiter plate; 3:1 mixture enriched in the faster eluting diastereoisomerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27662(4-[(3-{[4-(2-phenoxypropanoyl)piperazin-1-yl]carbo...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056584((S)-3-[7-(4-Carbamimidoyl-phenylethynyl)-1-methyl-...)
Affinity DataIC50:  5nMAssay Description:Binding affinity for soluble GPIIb/IIIa captured on fibrinogen coated microtiter plateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056586((S)-3-[7-(4-Carbamimidoyl-phenylethynyl)-9-chloro-...)
Affinity DataIC50:  7nMAssay Description:Binding affinity for soluble GPIIb/IIIa captured on fibrinogen coated microtiter plateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27661(4-({3-[(4-cyclopentanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  8nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056587(3-[7-(4-Carbamimidoyl-phenylethynyl)-1-methyl-2,5-...)
Affinity DataIC50:  11nMAssay Description:Binding affinity for soluble GPIIb/IIIa captured on fibrinogen coated microtiter plateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27680(2-({3-[(4-cyclopentanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  12nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056589((S)-3-[1-tert-Butyl-7-(4-carbamimidoyl-phenylethyn...)
Affinity DataIC50:  12nMAssay Description:Binding affinity for soluble GPIIb/IIIa captured on fibrinogen coated microtiter plate; 1:3 mixture enriched in the slower eluting diastereoisomerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27681(5-fluoro-2-[(4-fluoro-3-{[4-(2-phenoxypropanoyl)pi...)
Affinity DataIC50:  14nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27663(2-{[3-(piperazin-1-ylcarbonyl)phenyl]methoxy}benza...)
Affinity DataIC50:  18nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056585((R)-3-[1-tert-Butyl-7-(4-carbamimidoyl-phenylethyn...)
Affinity DataIC50:  18nMAssay Description:Binding affinity for soluble GPIIb/IIIa captured on fibrinogen coated microtiter plateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056585((R)-3-[1-tert-Butyl-7-(4-carbamimidoyl-phenylethyn...)
Affinity DataIC50:  18nMAssay Description:Binding affinity for soluble GPIIb/IIIa captured on fibrinogen coated microtiter plateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27674(2-[2-(4-fluoro-3-{[4-(2-phenoxypropanoyl)piperazin...)
Affinity DataIC50:  19nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302293(4-(1-(4,6-dimorpholino-1,3,5-triazin-2-yl)-1H-imid...)
Affinity DataIC50:  21nMAssay Description:Inhibition of mTOR kinase in human HeLa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302286(4-(5-(2,6-dimorpholinopyrimidin-4-yl)furan-2-yl)-2...)
Affinity DataIC50:  23nMAssay Description:Inhibition of mTOR kinase in human HeLa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27666(2-({3-[(4-cyclopentanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  24nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27675(5-fluoro-2-{[4-fluoro-3-(piperazin-1-ylcarbonyl)ph...)
Affinity DataIC50:  29nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056588((S)-3-[1-tert-Butyl-7-(4-carbamimidoyl-phenylethyn...)
Affinity DataIC50:  34nMAssay Description:Inhibition of 17.5 uM ADP-induced platelet aggregation of human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056588((S)-3-[1-tert-Butyl-7-(4-carbamimidoyl-phenylethyn...)
Affinity DataIC50:  34nMAssay Description:Inhibition of 17.5 uM ADP-induced platelet aggregation of human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27667(2-[(3-{[4-(2-phenoxypropanoyl)piperazin-1-yl]carbo...)
Affinity DataIC50:  36nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27668(2-[(4-fluoro-3-{[4-(2-phenoxypropanoyl)piperazin-1...)
Affinity DataIC50:  50nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302285(2,6-dimethoxy-4-(5-(2-morpholinopyrimidin-4-yl)fur...)
Affinity DataIC50:  52nMAssay Description:Inhibition of mTOR kinase in human HeLa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056590((R)-3-[7-(4-Carbamimidoyl-phenylethynyl)-1-methyl-...)
Affinity DataIC50:  60nMAssay Description:Binding affinity for soluble GPIIb/IIIa captured on fibrinogen coated microtiter plateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056588((S)-3-[1-tert-Butyl-7-(4-carbamimidoyl-phenylethyn...)
Affinity DataIC50:  60nMAssay Description:Inhibition of thrombin-induced platelet aggregation assay at 20 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27664(2-{[4-fluoro-3-(piperazin-1-ylcarbonyl)phenyl]meth...)
Affinity DataIC50:  61nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056584((S)-3-[7-(4-Carbamimidoyl-phenylethynyl)-1-methyl-...)
Affinity DataIC50:  78nMAssay Description:Inhibition of 17.5 uM ADP-induced platelet aggregation of human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056589((S)-3-[1-tert-Butyl-7-(4-carbamimidoyl-phenylethyn...)
Affinity DataIC50:  92nMAssay Description:Inhibition of 17.5 uM ADP-induced platelet aggregation of human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27672(2-(2-{3-[(4-cyclopentanecarbonylpiperazin-1-yl)car...)
Affinity DataIC50:  103nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056587(3-[7-(4-Carbamimidoyl-phenylethynyl)-1-methyl-2,5-...)
Affinity DataIC50:  120nMAssay Description:Inhibition of 17.5 uM ADP-induced platelet aggregation of human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056584((S)-3-[7-(4-Carbamimidoyl-phenylethynyl)-1-methyl-...)
Affinity DataIC50:  138nMAssay Description:Inhibition of thrombin-induced platelet aggregation assay at 20 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056586((S)-3-[7-(4-Carbamimidoyl-phenylethynyl)-9-chloro-...)
Affinity DataIC50:  159nMAssay Description:Inhibition of 17.5 uM ADP-induced platelet aggregation of human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302284(2,6-dimethoxy-4-(2-(2-morpholinopyrimidin-4-yl)thi...)
Affinity DataIC50:  180nMAssay Description:Inhibition of mTOR kinase in human HeLa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27665(2-({3-[(4-cyclopentanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  188nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27671(2-(2-{3-[(4-cyclopentanecarbonylpiperazin-1-yl)car...)
Affinity DataIC50:  200nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27673(2-[2-(3-{[4-(2-phenoxypropanoyl)piperazin-1-yl]car...)
Affinity DataIC50:  200nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056587(3-[7-(4-Carbamimidoyl-phenylethynyl)-1-methyl-2,5-...)
Affinity DataIC50:  213nMAssay Description:Inhibition of thrombin-induced platelet aggregation assay at 20 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27676(4,5-difluoro-2-{[4-fluoro-3-(piperazin-1-ylcarbony...)
Affinity DataIC50:  240nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27677(4-fluoro-2-{[4-fluoro-3-(piperazin-1-ylcarbonyl)ph...)
Affinity DataIC50:  250nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302275(4-((2-(4,6-dimorpholino-1,3,5-triazin-2-yl)hydrazo...)
Affinity DataIC50:  270nMAssay Description:Inhibition of mTOR kinase in human HeLa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50056586((S)-3-[7-(4-Carbamimidoyl-phenylethynyl)-9-chloro-...)
Affinity DataIC50:  313nMAssay Description:Inhibition of thrombin-induced platelet aggregation assay at 20 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302281(2,6-dimethoxy-4-(1-(2-morpholinopyrimidin-4-yl)-1H...)
Affinity DataIC50:  460nMAssay Description:Inhibition of mTOR kinase in human HeLa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302290((3-(5-(2,6-dimorpholinopyrimidin-4-yl)furan-2-yl)p...)
Affinity DataIC50:  510nMAssay Description:Inhibition of mTOR kinase in human HeLa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302291(4,4'-(6-(5-(pyridin-4-yl)furan-2-yl)pyrimidine-2,4...)
Affinity DataIC50:  520nMAssay Description:Inhibition of mTOR kinase in human HeLa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302287(4-(5-(2,6-dimorpholinopyrimidin-4-yl)furan-2-yl)ph...)
Affinity DataIC50:  550nMAssay Description:Inhibition of mTOR kinase in human HeLa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302282(2,6-dimethoxy-4-(6-(2-morpholinopyrimidin-4-yl)pyr...)
Affinity DataIC50:  550nMAssay Description:Inhibition of mTOR kinase in human HeLa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302283(2,6-dimethoxy-4-(4-(2-morpholinopyrimidin-4-yl)thi...)
Affinity DataIC50:  560nMAssay Description:Inhibition of mTOR kinase in human HeLa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302277(2,6-dimethoxy-4-(1-(4-morpholinopyrimidin-2-yl)-1H...)
Affinity DataIC50:  570nMAssay Description:Inhibition of mTOR kinase in human HeLa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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