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Found 38 with Last Name = 'blais' and Initial = 's'
TargetGlutamate--tRNA ligase(Escherichia coli)
Crefsip

LigandPNGBDBM18118((4S)-4-amino-6-({[(2R,3S,4R,5R)-5-(6-amino-9H-puri...)
Affinity DataKi:  1.80E+4nM ΔG°:  -28.2kJ/molepH: 7.2 T: 2°CAssay Description:The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamine--tRNA ligase(Escherichia coli)
Crefsip

LigandPNGBDBM18120(Gln-KPA | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)...)
Affinity DataKi:  6.50E+5nM ΔG°:  -18.9kJ/molepH: 7.2 T: 2°CAssay Description:The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamine--tRNA ligase(Bos taurus (bovine))
Crefsip

LigandPNGBDBM18118((4S)-4-amino-6-({[(2R,3S,4R,5R)-5-(6-amino-9H-puri...)
Affinity DataKi:  2.60E+6nM ΔG°:  -15.3kJ/molepH: 7.2 T: 2°CAssay Description:The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamine--tRNA ligase(Escherichia coli)
Crefsip

LigandPNGBDBM18118((4S)-4-amino-6-({[(2R,3S,4R,5R)-5-(6-amino-9H-puri...)
Affinity DataKi:  2.80E+6nM ΔG°:  -15.2kJ/molepH: 7.2 T: 2°CAssay Description:The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate--tRNA ligase(Escherichia coli)
Crefsip

LigandPNGBDBM18120(Gln-KPA | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)...)
Affinity DataKi:  2.90E+6nM ΔG°:  -15.1kJ/molepH: 7.2 T: 2°CAssay Description:The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50333940(4-((4-(4'-acetylbiphenyl-4-yl)-5-fluorothiophene-2...)
Affinity DataIC50:  7nMAssay Description:Inhibition of MMP-12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50333942((R)-3-(5-fluoro-4-(4-(pyridin-4-yl)phenyl)thiophen...)
Affinity DataIC50:  13nMAssay Description:Inhibition of MMP-12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50170205((R)-Phenyl-{[4-(4-pyridin-4-yl-phenyl)-thiophene-2...)
Affinity DataIC50:  14nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50333941((R)-3-(4-(4'-acetylbiphenyl-4-yl)-5-fluorothiophen...)
Affinity DataIC50:  24nMAssay Description:Inhibition of MMP-12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50170206(4-(4'-Acetyl-biphenyl-4-yl)-thiophene-2-carboxylic...)
Affinity DataIC50:  57nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50170203((4-Biphenyl-4-yl-thiophene-2-carbonyl)-carbamic ac...)
Affinity DataIC50:  70nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50170207(CHEMBL180762 | [4-(2'-Hydroxy-biphenyl-4-yl)-thiop...)
Affinity DataIC50:  70nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50333939((R)-N-(3-amino-3-oxo-1-phenylpropyl)-5-fluoro-4-(4...)
Affinity DataIC50:  85nMAssay Description:Inhibition of MMP-12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50170201(4-(4-Pyridin-4-yl-phenyl)-thiophene-2-carboxylic a...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Matrix metalloprotease-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50170201(4-(4-Pyridin-4-yl-phenyl)-thiophene-2-carboxylic a...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50333937(CHEMBL1644426 | trans-4-((5-fluoro-4-(4-(trifluoro...)
Affinity DataIC50:  140nMAssay Description:Inhibition of MMP-12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50170211((R)-Phenyl-{[4-(4-trifluoromethoxy-phenyl)-thiophe...)
Affinity DataIC50:  180nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50333938((R)-3-(5-fluoro-4-(4-(trifluoromethoxy)phenyl)thio...)
Affinity DataIC50:  200nMAssay Description:Inhibition of MMP-12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50:  230nMAssay Description:Inhibition of Matrix metalloproteinase-12 in pressence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170205((R)-Phenyl-{[4-(4-pyridin-4-yl-phenyl)-thiophene-2...)
Affinity DataIC50:  270nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50170209(4-Biphenyl-4-yl-thiophene-2-carboxylic acid (2-mor...)
Affinity DataIC50:  400nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50170212(CHEMBL181817 | [4-(4-Trifluoromethoxy-phenyl)-thio...)
Affinity DataIC50:  400nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50170210(CHEMBL367148 | [4-(4-Trifluoromethoxy-phenyl)-thio...)
Affinity DataIC50:  400nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50333934(CHEMBL1644423 | trans-4-((4-(4-(trifluoromethoxy)p...)
Affinity DataIC50:  400nMAssay Description:Inhibition of MMP-12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50170208(4-(4-Cyclohexyl-phenyl)-thiophene-2-carboxylic aci...)
Affinity DataIC50:  460nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170203((4-Biphenyl-4-yl-thiophene-2-carbonyl)-carbamic ac...)
Affinity DataIC50: >1.20E+3nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170211((R)-Phenyl-{[4-(4-trifluoromethoxy-phenyl)-thiophe...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170207(CHEMBL180762 | [4-(2'-Hydroxy-biphenyl-4-yl)-thiop...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50333935(CHEMBL1644424 | trans-4-((3-(4-(trifluoromethoxy)p...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of MMP-12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50170204((S)-Phenyl-{[4-(4-trifluoromethoxy-phenyl)-thiophe...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of Matrix metalloprotease-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of Matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of Matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Evotec Oai

Curated by ChEMBL
LigandPNGBDBM50333936(CHEMBL1644425 | trans-4-((5-(4-(trifluoromethoxy)p...)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibition of MMP-12 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: >1.01E+5nMAssay Description:Inhibition of Matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: >1.01E+5nMAssay Description:Inhibition of Matrix metalloprotease-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: >1.01E+5nMAssay Description:Inhibition of Matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed