Found 40 with Last Name = 'bland' and Initial = 'nd' 
Affinity DataIC50: 4nMAssay Description:Inhibition of Trypanosoma brucei PDEB1More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Northeastern University
Curated by ChEMBL
Northeastern University
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of human PDE4B expressed in Sf21 cells using cAMP substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 278nMAssay Description:Inhibition of Trypanosoma brucei PDEB1More data for this Ligand-Target Pair
Affinity DataIC50: 950nMAssay Description:Inhibition of Trypanosoma brucei recombinant PDEB1 pre-incubated for 5 mins prior to substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of Trypanosoma brucei recombinant PDEB1 pre-incubated for 5 mins prior to substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of Trypanosoma brucei recombinant PDEB1 pre-incubated for 5 mins prior to substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of Trypanosoma brucei recombinant PDEB1 pre-incubated for 5 mins prior to substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 5.90E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 5.90E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 5.90E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 6.40E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 6.70E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90E+3nMAssay Description:This assay was performed at Takeda Pharmaceuticals using methods previously reported.More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of Trypanosoma brucei recombinant PDEB1 pre-incubated for 5 mins prior to substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of Trypanosoma brucei recombinant PDEB1 pre-incubated for 5 mins prior to substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of Trypanosoma brucei recombinant PDEB1 pre-incubated for 5 mins prior to substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of Trypanosoma brucei recombinant PDEB1 pre-incubated for 5 mins prior to substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of Trypanosoma brucei recombinant PDEB1 pre-incubated for 5 mins prior to substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of Trypanosoma brucei recombinant PDEB1 pre-incubated for 5 mins prior to substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+4nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+4nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+4nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+4nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+4nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+4nMAssay Description:This assay was performed at Takeda Pharmaceuticals using methods previously reported.More data for this Ligand-Target Pair
Affinity DataIC50: 8.30E+4nMAssay Description:This assay was performed at Takeda Pharmaceuticals using methods previously reported.More data for this Ligand-Target Pair
