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Found 53 with Last Name = 'blasdel' and Initial = 'l'
LigandPNGBDBM14797(Pyrazole carboxylic ester 20 | ethyl 1-(2-chloroph...)
Affinity DataIC50:  19nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14798(Pyrazole carboxylic ester 21 | ethyl 3,5-dimethyl-...)
Affinity DataIC50:  21nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50398608(MARIZOMIB)
Affinity DataIC50:  22nMAssay Description:Inhibition of chymotrypsin like activity of human 20S proteasome after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50444464(CHEMBL192046)
Affinity DataIC50:  23nMAssay Description:Inhibition of chymotrypsin like activity of human 20S proteasome after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50444462(CHEMBL3092609)
Affinity DataIC50:  28nMAssay Description:Inhibition of chymotrypsin like activity of human 20S proteasome after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14798(Pyrazole carboxylic ester 21 | ethyl 3,5-dimethyl-...)
Affinity DataIC50:  33nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50444463(CHEMBL3092608)
Affinity DataIC50:  50nMAssay Description:Inhibition of chymotrypsin like activity of human 20S proteasome after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14797(Pyrazole carboxylic ester 20 | ethyl 1-(2-chloroph...)
Affinity DataIC50:  56nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
LigandPNGBDBM14796(Pyrazole carboxylic ester 19 | ethyl 1-(4-aminophe...)
Affinity DataIC50:  160nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
LigandPNGBDBM14785(Pyrazole carboxylic ester 8 | ethyl 3,5-dimethyl-1...)
Affinity DataIC50:  270nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
LigandPNGBDBM14785(Pyrazole carboxylic ester 8 | ethyl 3,5-dimethyl-1...)
Affinity DataIC50:  310nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50444466(CHEMBL3092611)
Affinity DataIC50:  330nMAssay Description:Inhibition of chymotrypsin like activity of human 20S proteasome after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14796(Pyrazole carboxylic ester 19 | ethyl 1-(4-aminophe...)
Affinity DataIC50:  350nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50444465(CHEMBL3092612)
Affinity DataIC50:  500nMAssay Description:Inhibition of chymotrypsin like activity of human 20S proteasome after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50444461(CHEMBL3092610)
Affinity DataIC50:  500nMAssay Description:Inhibition of chymotrypsin like activity of human 20S proteasome after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14795(Pyrazole carboxylic ester 18 | ethyl 3,5-dimethyl-...)
Affinity DataIC50:  840nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14786(Pyrazole carboxylic ester 9 | ethyl 3-(4-chlorophe...)
Affinity DataIC50:  880nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14795(Pyrazole carboxylic ester 18 | ethyl 3,5-dimethyl-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14786(Pyrazole carboxylic ester 9 | ethyl 3-(4-chlorophe...)
Affinity DataIC50:  1.50E+3nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14794(Pyrazole carboxylic ester 17 | ethyl 1-(4-methoxyp...)
Affinity DataIC50:  2.00E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
LigandPNGBDBM14790(Pyrazole carboxylic ester 13 | ethyl 1-(2,4-dinitr...)
Affinity DataIC50:  4.60E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM14794(Pyrazole carboxylic ester 17 | ethyl 1-(4-methoxyp...)
Affinity DataIC50:  5.90E+3nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14793(Pyrazole carboxylic ester 16 | ethyl 3,5-dimethyl-...)
Affinity DataIC50:  9.10E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM14793(Pyrazole carboxylic ester 16 | ethyl 3,5-dimethyl-...)
Affinity DataIC50:  1.30E+4nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM14792(Pyrazole carboxylic ester 15 | ethyl 1-(4-tert-but...)
Affinity DataIC50:  1.40E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14784(Pyrazole carboxylic ester 7 | cid_707658 | ethyl 3...)
Affinity DataIC50:  1.50E+4nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14787(Pyrazole carboxylic ester 10 | ethyl 3,5-dimethyl-...)
Affinity DataIC50:  1.70E+4nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14790(Pyrazole carboxylic ester 13 | ethyl 1-(2,4-dinitr...)
Affinity DataIC50:  1.70E+4nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM14792(Pyrazole carboxylic ester 15 | ethyl 1-(4-tert-but...)
Affinity DataIC50:  1.90E+4nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14784(Pyrazole carboxylic ester 7 | cid_707658 | ethyl 3...)
Affinity DataIC50:  1.90E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14787(Pyrazole carboxylic ester 10 | ethyl 3,5-dimethyl-...)
Affinity DataIC50:  1.90E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14791(Pyrazole carboxylic ester 14 | ethyl 3,5-dimethyl-...)
Affinity DataIC50:  2.10E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14788(Pyrazole carboxylic ester 11 | ethyl 5-amino-1-{8-...)
Affinity DataIC50:  2.50E+4nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14791(Pyrazole carboxylic ester 14 | ethyl 3,5-dimethyl-...)
Affinity DataIC50:  3.20E+4nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14788(Pyrazole carboxylic ester 11 | ethyl 5-amino-1-{8-...)
Affinity DataIC50:  5.00E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14779(Pyrazole carboxylic ester 2 | ethyl 3,5-dimethyl-1...)
Affinity DataIC50:  6.00E+4nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14779(Pyrazole carboxylic ester 2 | ethyl 3,5-dimethyl-1...)
Affinity DataIC50:  8.20E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
LigandPNGBDBM14789(Pyrazole carboxylic ester 12 | ethyl 1-[3,5-bis(tr...)
Affinity DataIC50:  9.70E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM14789(Pyrazole carboxylic ester 12 | ethyl 1-[3,5-bis(tr...)
Affinity DataIC50:  1.60E+5nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM14778(3,5-dimethyl-1H-pyrazole-4-carboxylic acid | Pyraz...)
Affinity DataIC50: >2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14780(Pyrazole carboxylic ester 3 | ethyl 3-methyl-1H-py...)
Affinity DataIC50: >2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14781(Pyrazole carboxylic ester 4 | ethyl 3-amino-1H-pyr...)
Affinity DataIC50: >2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14783(Pyrazole carboxylic ester 6 | methyl 3-methyl-5-(5...)
Affinity DataIC50: >2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14782(5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ...)
Affinity DataIC50: >2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14778(3,5-dimethyl-1H-pyrazole-4-carboxylic acid | Pyraz...)
Affinity DataIC50: >2.00E+5nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14780(Pyrazole carboxylic ester 3 | ethyl 3-methyl-1H-py...)
Affinity DataIC50: >2.00E+5nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14781(Pyrazole carboxylic ester 4 | ethyl 3-amino-1H-pyr...)
Affinity DataIC50: >2.00E+5nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14783(Pyrazole carboxylic ester 6 | methyl 3-methyl-5-(5...)
Affinity DataIC50: >2.00E+5nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14782(5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ...)
Affinity DataIC50: >2.00E+5nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50444461(CHEMBL3092610)
Affinity DataEC50:  332nMAssay Description:Inhibition of chymotrypsin like activity of 20S proteasome in HEK293 cells after 24 hrs by microscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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