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Found 108 with Last Name = 'bockovich' and Initial = 'n'
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59229(Pyrazolopyrimidone analog, RGB-286331)
Affinity DataIC50:  4nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59228(Pyrazolopyrimidone analog, RGB-285940)
Affinity DataIC50:  7nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59230(Pyrazolopyrimidone analog, RGB-285960)
Affinity DataIC50:  9nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  9nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  10nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  15nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59235(PEGylated derivative, RGB-286276)
Affinity DataIC50:  22nMAssay Description:In vitro kinase activity of PEGylated pyrazolopyrimidone CDK inhibitor or a 5 PEG-amine was coupled to ReactiGel agarose beads (Pierce, No. 20259).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59235(PEGylated derivative, RGB-286276)
Affinity DataIC50:  34nMAssay Description:Inhibition of HCT116 cell proliferation with compounds using calcein AM Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59229(Pyrazolopyrimidone analog, RGB-286331)
Affinity DataIC50:  43nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  48nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  51nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59230(Pyrazolopyrimidone analog, RGB-285960)
Affinity DataIC50:  64nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCDK-activating kinase assembly factor MAT1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  71nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59235(PEGylated derivative, RGB-286276)
Affinity DataIC50:  84nMAssay Description:In vitro kinase activity of PEGylated pyrazolopyrimidone CDK inhibitor or a 5 PEG-amine was coupled to ReactiGel agarose beads (Pierce, No. 20259).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50079331(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-m...)
Affinity DataIC50:  155nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59229(Pyrazolopyrimidone analog, RGB-286331)
Affinity DataIC50:  220nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50079331(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-m...)
Affinity DataIC50:  221nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59228(Pyrazolopyrimidone analog, RGB-285940)
Affinity DataIC50:  230nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  282nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59230(Pyrazolopyrimidone analog, RGB-285960)
Affinity DataIC50:  310nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59228(Pyrazolopyrimidone analog, RGB-285940)
Affinity DataIC50:  410nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50079331(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-m...)
Affinity DataIC50:  485nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50079331(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-m...)
Affinity DataIC50:  663nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  754nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  839nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59228(Pyrazolopyrimidone analog, RGB-285940)
Affinity DataIC50:  858nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59235(PEGylated derivative, RGB-286276)
Affinity DataIC50:  890nMAssay Description:In vitro kinase activity of PEGylated pyrazolopyrimidone CDK inhibitor or a 5 PEG-amine was coupled to ReactiGel agarose beads (Pierce, No. 20259).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50079331(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-m...)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59230(Pyrazolopyrimidone analog, RGB-285960)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289899(CHEMBL292556 | Sulfuric acid mono-[5-phenyl-1-((1S...)
Affinity DataIC50:  3.80E+3nMAssay Description:Concentration required for its inhibitory activity against Cdc25A phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289900(CHEMBL303581 | Sulfuric acid mono-[5-furan-3-yl-1-...)
Affinity DataIC50:  4.20E+3nMAssay Description:Concentration required for its inhibitory activity against Cdc25A phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289900(CHEMBL303581 | Sulfuric acid mono-[5-furan-3-yl-1-...)
Affinity DataIC50:  4.20E+3nMAssay Description:Concentration required for its inhibitory activity against Cdc25A phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289899(CHEMBL292556 | Sulfuric acid mono-[5-phenyl-1-((1S...)
Affinity DataIC50:  4.60E+3nMAssay Description:Concentration required for its inhibitory activity against VHR phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286608(CHEMBL60072 | Sulfircin analogue | Sulfuric acid m...)
Affinity DataIC50:  4.70E+3nMAssay Description:Concentration required for its inhibitory activity against VHR phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289899(CHEMBL292556 | Sulfuric acid mono-[5-phenyl-1-((1S...)
Affinity DataIC50:  5.40E+3nMAssay Description:Concentration required for its inhibitory activity against PTB1B phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59233(Pyrazolopyrimidone analog, RGB-310590)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289906(2-[3-Phenyl-1-((1S,2S,4aS,8aR)-2,5,5,8a-tetramethy...)
Affinity DataIC50:  5.60E+3nMAssay Description:Concentration required for its inhibitory activity against VHR phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289906(2-[3-Phenyl-1-((1S,2S,4aS,8aR)-2,5,5,8a-tetramethy...)
Affinity DataIC50:  6.30E+3nMAssay Description:Concentration required for its inhibitory activity against Cdc25A phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286608(CHEMBL60072 | Sulfircin analogue | Sulfuric acid m...)
Affinity DataIC50:  7.80E+3nMAssay Description:Concentration required for its inhibitory activity against Cdc25A phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289897(CHEMBL60297 | Sulfuric acid mono-[5-furan-3-yl-2-m...)
Affinity DataIC50:  7.90E+3nMAssay Description:Concentration required for its inhibitory activity against VHR phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289897(CHEMBL60297 | Sulfuric acid mono-[5-furan-3-yl-2-m...)
Affinity DataIC50:  8.40E+3nMAssay Description:Concentration required for its inhibitory activity against Cdc25A phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289902(2-[3-Oxo-3-phenyl-1-((4aS,8aS)-2,5,5,8a-tetramethy...)
Affinity DataIC50:  8.60E+3nMAssay Description:Concentration required for its inhibitory activity against VHR phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59231(Pyrazolopyrimidone analog, RGB-310596)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59234(Pyrazolopyrimidone analog, RGB-310591)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59232(Pyrazolopyrimidone analog, RGB-310595)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289900(CHEMBL303581 | Sulfuric acid mono-[5-furan-3-yl-1-...)
Affinity DataIC50:  1.08E+4nMAssay Description:Concentration required for its inhibitory activity against VHR phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289900(CHEMBL303581 | Sulfuric acid mono-[5-furan-3-yl-1-...)
Affinity DataIC50:  1.08E+4nMAssay Description:Concentration required for its inhibitory activity against Cdc25A phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289900(CHEMBL303581 | Sulfuric acid mono-[5-furan-3-yl-1-...)
Affinity DataIC50:  1.10E+4nMAssay Description:Concentration required for its inhibitory activity against PTB1B phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289900(CHEMBL303581 | Sulfuric acid mono-[5-furan-3-yl-1-...)
Affinity DataIC50:  1.10E+4nMAssay Description:Concentration required for its inhibitory activity against PTB1B phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289903(CHEMBL64690 | Sulfuric acid mono-[3-phenyl-1-((1S,...)
Affinity DataIC50:  1.65E+4nMAssay Description:Concentration required for its inhibitory activity against Cdc25A phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
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