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Found 37 with Last Name = 'bolm' and Initial = 'c'
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50324804((2-(4-(methylsulfonyl)phenyl)hex-1-ene-1,1-diyl)di...)
Affinity DataIC50:  14nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human platelets COX1 assessed as PGE2 production using arachidonic acid as substrate preincubated for 15 mins measured after 15 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124574(CHEMBL3623737)
Affinity DataIC50:  35nMAssay Description:Inhibition of recombinant AKR1C3 (unknown origin) using S-tetralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124577(CHEMBL3623738)
Affinity DataIC50:  36nMAssay Description:Inhibition of recombinant AKR1C3 (unknown origin) using S-tetralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50350507(CHEMBL1814813)
Affinity DataIC50:  42nMAssay Description:Inhibition of human platelets COX1 assessed as PGE2 production using arachidonic acid as substrate preincubated for 15 mins measured after 15 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human platelet COX1 using arachidonic acid as substrate preincubated for 15 mins before arachidonic acid addition measured after 15 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124575(CHEMBL3623735)
Affinity DataIC50:  57nMAssay Description:Inhibition of recombinant AKR1C3 (unknown origin) using S-tetralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124576(CHEMBL3623736)
Affinity DataIC50:  86nMAssay Description:Inhibition of recombinant AKR1C3 (unknown origin) using S-tetralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124577(CHEMBL3623738)
Affinity DataIC50:  150nMAssay Description:Inhibition of recombinant AKR1C2 (unknown origin) using S-tetralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50350507(CHEMBL1814813)
Affinity DataIC50:  156nMAssay Description:Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as PGE2 production using arachidonic acid as substrate preincubated for 15 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50:  156nMAssay Description:Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as PGE2 production using arachidonic acid as substrate preincubated for 15 mins...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human recombinant COX2 expressed in Sf21 cells using arachidonic acid as substrate preincubated for 15 mins before arachidonic acid add...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124575(CHEMBL3623735)
Affinity DataIC50:  270nMAssay Description:Inhibition of recombinant AKR1C2 (unknown origin) using S-tetralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50561594(CHEMBL4790505)
Affinity DataIC50:  500nMAssay Description:Inhibition of BRD4 in human HEL cells harboring JAK2 V617F mutant assessed as decrease in metabolic activity measured after 72 hrs by MTT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM20625(4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)
Affinity DataIC50:  610nMAssay Description:Displacement of [3H]-estradiol from human recombinant ERbeta expressed in Sf21 cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM20625(4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)
Affinity DataIC50:  770nMAssay Description:Displacement of [3H]-estradiol from human recombinant ERalpha expressed in Sf21 cells after 2 hrsMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50561594(CHEMBL4790505)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BRD4 in human MOLM-14 cells harboring FLT3-ITD mutant assessed as decrease in metabolic activity measured after 72 hrs by MTT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124575(CHEMBL3623735)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of COX1 (unknown origin) using arachidonic acid substrate by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50399434(CHEMBL2179387)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of BRD4 in human HEL cells harboring JAK2 V617F mutant assessed as decrease in metabolic activity measured after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50399434(CHEMBL2179387)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of BRD4 in human MOLM-14 cells harboring FLT3-ITD mutant assessed as decrease in metabolic activity measured after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124575(CHEMBL3623735)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of COX2 (unknown origin) using arachidonic acid substrate by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124576(CHEMBL3623736)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of recombinant AKR1C2 (unknown origin) using S-tetralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124574(CHEMBL3623737)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of recombinant AKR1C2 (unknown origin) using S-tetralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124577(CHEMBL3623738)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of COX1 (unknown origin) using arachidonic acid substrate by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50350507(CHEMBL1814813)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as inhibition of tail current at holding potential of -70 mV after 10 mins by whole-cell p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124577(CHEMBL3623738)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of COX2 (unknown origin) using arachidonic acid substrate by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124576(CHEMBL3623736)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of COX1 (unknown origin) using arachidonic acid substrate by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124576(CHEMBL3623736)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of COX2 (unknown origin) using arachidonic acid substrate by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124574(CHEMBL3623737)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of COX2 (unknown origin) using arachidonic acid substrate by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124574(CHEMBL3623737)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of COX1 (unknown origin) using arachidonic acid substrate by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50419031(CHEMBL2029168)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as inhibition of tail current at holding potential of -70 mV after 10 mins by whole-cell p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50324804((2-(4-(methylsulfonyl)phenyl)hex-1-ene-1,1-diyl)di...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 5(Rattus norvegicus)
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM17636(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
Affinity DataEC50:  2.60E+6nMAssay Description:Binding affinity to rat bile acid-sensitive ion channel expressed in xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 5(Rattus norvegicus)
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124576(CHEMBL3623736)
Affinity DataEC50:  2.90E+6nMAssay Description:Binding affinity to rat bile acid-sensitive ion channel expressed in xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 5(Rattus norvegicus)
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124575(CHEMBL3623735)
Affinity DataEC50:  1.40E+6nMAssay Description:Binding affinity to rat bile acid-sensitive ion channel expressed in xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 5(Rattus norvegicus)
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124574(CHEMBL3623737)
Affinity DataEC50:  2.80E+6nMAssay Description:Binding affinity to rat bile acid-sensitive ion channel expressed in xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 5(Rattus norvegicus)
Rwth Aachen University

Curated by ChEMBL
LigandPNGBDBM50124577(CHEMBL3623738)
Affinity DataEC50:  2.60E+6nMAssay Description:Binding affinity to rat bile acid-sensitive ion channel expressed in xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed