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Found 265 with Last Name = 'booker' and Initial = 'm'
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323215((2S,3S)-N-((S)-1-(4-(5-(2-cyclohexylethyl)-1,2,4-o...)
Affinity DataIC50:  10nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323216((2S,3S)-N-((S)-1-(4-(5-(2-cyclohexylethyl)-1,2,4-o...)
Affinity DataIC50:  20nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323223((2S,3S)-N-(4-(5-(2-cyclohexylethyl)-1,2,4-oxadiazo...)
Affinity DataIC50:  25nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323219((2S,3S)-N-((S)-1-(4-(5-heptyl-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120351(US8703811, 93)
Affinity DataIC50:  35nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120317(US8703811, 58)
Affinity DataIC50:  36nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120319(US8703811, 60)
Affinity DataIC50:  38nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium vivax)
Harvard Medical School

LigandPNGBDBM92606(DHOD Inhibitor, 5 | US8703811, 6)
Affinity DataIC50:  40nMAssay Description:Assay was determined using a continuous assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium vivax)
Harvard Medical School

LigandPNGBDBM92606(DHOD Inhibitor, 5 | US8703811, 6)
Affinity DataIC50:  40nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120301(US8703811, 40 | US8703811, 41)
Affinity DataIC50:  40nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120323(US8703811, 64)
Affinity DataIC50:  41nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120324(US8703811, 65)
Affinity DataIC50:  42nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM92604(DHOD Inhibitor, 3 | US8703811, 1)
Affinity DataIC50:  42nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323220((2S,3S)-N-((S)-1-(4-(5-heptyl-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  48nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323231((2S,3S)-N-(4-(5-hexyl-1,2,4-oxadiazol-3-yl)benzyl)...)
Affinity DataIC50:  49nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50299323((S)-2-amino-4-hydroxy-N-(4-octylphenyl)butanamide ...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human sphingosine kinase 1 by off chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120305(US8703811, 44)
Affinity DataIC50:  56nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323242((2S,3S)-N-((S)-1-(4-(5-(2-cyclopentylethyl)-1,2,4-...)
Affinity DataIC50:  56nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120315(US8703811, 55)
Affinity DataIC50:  56nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM50379142(CHEMBL2012824 | US8703811, 23)
Affinity DataIC50:  56nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323217((2S,3S)-N-((S)-1-(4-(5-(2-cyclopentylethyl)-1,2,4-...)
Affinity DataIC50:  58nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120301(US8703811, 40 | US8703811, 41)
Affinity DataIC50:  58nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120328(US8703811, 70)
Affinity DataIC50:  58nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517](Plasmodium berghei)
Harvard Medical School

LigandPNGBDBM92606(DHOD Inhibitor, 5 | US8703811, 6)
Affinity DataIC50:  60nMAssay Description:Assay was determined using a continuous assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517](Plasmodium berghei)
Harvard Medical School

LigandPNGBDBM92604(DHOD Inhibitor, 3 | US8703811, 1)
Affinity DataIC50:  60nMAssay Description:Assay was determined using a continuous assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517](Plasmodium berghei)
Harvard Medical School

LigandPNGBDBM92604(DHOD Inhibitor, 3 | US8703811, 1)
Affinity DataIC50:  60nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517](Plasmodium berghei)
Harvard Medical School

LigandPNGBDBM92606(DHOD Inhibitor, 5 | US8703811, 6)
Affinity DataIC50:  60nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323234((2S,3S)-N-(4-(3-heptyl-1,2,4-oxadiazol-5-yl)benzyl...)
Affinity DataIC50:  61nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50299328((2S,3S)-3-hydroxy-N-(4-octylphenyl)pyrrolidine-2-c...)
Affinity DataIC50:  62nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50299328((2S,3S)-3-hydroxy-N-(4-octylphenyl)pyrrolidine-2-c...)
Affinity DataIC50:  62nMAssay Description:Inhibition of human sphingosine kinase 1 by off chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM92604(DHOD Inhibitor, 3 | US8703811, 1)
Affinity DataIC50:  64nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM50379157(CHEMBL1234899 | US8703811, 57)
Affinity DataIC50:  64nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120325(US8703811, 66)
Affinity DataIC50:  67nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323240((2S,3S)-N-(4-(5-heptyl-1,2,4-oxadiazol-3-yl)benzyl...)
Affinity DataIC50:  68nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323225((2S,3S)-N-(4-(5-(2-cyclopentylethyl)-1,2,4-oxadiaz...)
Affinity DataIC50:  68nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323233((2S,3S)-N-(4-(5-heptylthiazol-2-yl)benzyl)-3-hydro...)
Affinity DataIC50:  70nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM92604(DHOD Inhibitor, 3 | US8703811, 1)
Affinity DataIC50:  70nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM50379146(CHEMBL2012829 | US8703811, 31 | US8703811, 32)
Affinity DataIC50:  74nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120320(US8703811, 61)
Affinity DataIC50:  75nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM92606(DHOD Inhibitor, 5 | US8703811, 6)
Affinity DataIC50:  83nMAssay Description:Assay was determined using a continuous assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM92606(DHOD Inhibitor, 5 | US8703811, 6)
Affinity DataIC50:  83nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323238((2S,3S)-3-hydroxy-N-(4-(5-octyl-1,2,4-oxadiazol-3-...)
Affinity DataIC50:  86nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120303(US8703811, 42 | US8703811, 43)
Affinity DataIC50:  88nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120356(US8703811, 98)
Affinity DataIC50:  89nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120312(US8703811, 52)
Affinity DataIC50:  94nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM50379146(CHEMBL2012829 | US8703811, 31 | US8703811, 32)
Affinity DataIC50:  99nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379157(CHEMBL1234899 | US8703811, 57)
Affinity DataIC50:  100nMAssay Description:Inhibition of human CYP2D6 using bufuralol as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120303(US8703811, 42 | US8703811, 43)
Affinity DataIC50:  104nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120326(US8703811, 68)
Affinity DataIC50:  105nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme

US Patent
LigandPNGBDBM120353(US8703811, 95)
Affinity DataIC50:  105nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails US Patent
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