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Found 73 with Last Name = 'bora' and Initial = 'e'
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513317(CHEMBL4465620)
Affinity DataKi:  68nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513318(CHEMBL4516553)
Affinity DataKi:  470nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50596052(CHEMBL5196484)
Affinity DataIC50:  87nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255048(3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-[(5...)
Affinity DataIC50:  100nMAssay Description:Binding affinity to SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50595758(CHEMBL5207682)
Affinity DataIC50:  126nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255048(3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-[(5...)
Affinity DataIC50:  300nMAssay Description:Binding affinity to ABL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50148781(CHEMBL3770903)
Affinity DataIC50:  300nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513317(CHEMBL4465620)
Affinity DataIC50:  310nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513320(CHEMBL4471909)
Affinity DataIC50:  370nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50595759(CHEMBL5175995)
Affinity DataIC50:  444nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50595760(CHEMBL5177373)
Affinity DataIC50:  457nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255048(3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-[(5...)
Affinity DataIC50:  500nMAssay Description:Binding affinity to LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50596051(CHEMBL5183243)
Affinity DataIC50:  570nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513318(CHEMBL4516553)
Affinity DataIC50:  600nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50596053(CHEMBL5173876)
Affinity DataIC50:  930nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity by HPLC assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetAurora kinase A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255012(5-((4-(methylsulfonyl)benzylamino)methyl)-3,4-difl...)
Affinity DataIC50:  1.00E+3nMAssay Description:Binding affinity to Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513319(CHEMBL4589851)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50595757(CHEMBL5174314)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50:  1.74E+3nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255048(3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-[(5...)
Affinity DataIC50:  2.00E+3nMAssay Description:Binding affinity to FGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255013((S)-5-((2,4-diamino-4-oxobutanamido)methyl)-3,4-di...)
Affinity DataIC50:  2.00E+3nMAssay Description:Binding affinity to Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255012(5-((4-(methylsulfonyl)benzylamino)methyl)-3,4-difl...)
Affinity DataIC50:  2.00E+3nMAssay Description:Binding affinity to TRAK-A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255013((S)-5-((2,4-diamino-4-oxobutanamido)methyl)-3,4-di...)
Affinity DataIC50:  2.00E+3nMAssay Description:Binding affinity to PKC beta2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255049(5-{[2-(4-Chloro-benzenesulfonyl)-acetyl]-hydrazono...)
Affinity DataIC50:  3.00E+3nMAssay Description:Binding affinity to CLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255048(3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-[(5...)
Affinity DataIC50:  3.00E+3nMAssay Description:Binding affinity to VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255048(3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-[(5...)
Affinity DataIC50:  3.00E+3nMAssay Description:Binding affinity to Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255049(5-{[2-(4-Chloro-benzenesulfonyl)-acetyl]-hydrazono...)
Affinity DataIC50:  3.00E+3nMAssay Description:Binding affinity to SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255048(3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-[(5...)
Affinity DataIC50:  3.00E+3nMAssay Description:Binding affinity to ECK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255013((S)-5-((2,4-diamino-4-oxobutanamido)methyl)-3,4-di...)
Affinity DataIC50:  4.00E+3nMAssay Description:Binding affinity to SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255049(5-{[2-(4-Chloro-benzenesulfonyl)-acetyl]-hydrazono...)
Affinity DataIC50:  4.00E+3nMAssay Description:Binding affinity to Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255048(3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-[(5...)
Affinity DataIC50:  4.00E+3nMAssay Description:Binding affinity to MAP3K9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255049(5-{[2-(4-Chloro-benzenesulfonyl)-acetyl]-hydrazono...)
Affinity DataIC50:  4.00E+3nMAssay Description:Binding affinity to ABL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255049(5-{[2-(4-Chloro-benzenesulfonyl)-acetyl]-hydrazono...)
Affinity DataIC50:  5.00E+3nMAssay Description:Binding affinity to TRAK-A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255012(5-((4-(methylsulfonyl)benzylamino)methyl)-3,4-difl...)
Affinity DataIC50:  5.00E+3nMAssay Description:Binding affinity to MAP3K9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255013((S)-5-((2,4-diamino-4-oxobutanamido)methyl)-3,4-di...)
Affinity DataIC50:  6.00E+3nMAssay Description:Binding affinity to MST2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255048(3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-[(5...)
Affinity DataIC50:  7.00E+3nMAssay Description:Binding affinity to BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255049(5-{[2-(4-Chloro-benzenesulfonyl)-acetyl]-hydrazono...)
Affinity DataIC50:  7.00E+3nMAssay Description:Binding affinity to LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255049(5-{[2-(4-Chloro-benzenesulfonyl)-acetyl]-hydrazono...)
Affinity DataIC50:  7.00E+3nMAssay Description:Binding affinity to MAP3K9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA demethylase ALKBH5(Homo sapiens)
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50596051(CHEMBL5183243)
Affinity DataIC50:  7.13E+3nMAssay Description:Inhibition of ALKBH5 (unknown origin) demethylation activityMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRNA demethylase ALKBH5(Homo sapiens)
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50596052(CHEMBL5196484)
Affinity DataIC50:  8.98E+3nMAssay Description:Inhibition of ALKBH5 (unknown origin) demethylation activityMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255013((S)-5-((2,4-diamino-4-oxobutanamido)methyl)-3,4-di...)
Affinity DataIC50:  1.30E+4nMAssay Description:Binding affinity to TRAK-A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255048(3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-[(5...)
Affinity DataIC50:  1.50E+4nMAssay Description:Binding affinity to CLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255012(5-((4-(methylsulfonyl)benzylamino)methyl)-3,4-difl...)
Affinity DataIC50:  1.80E+4nMAssay Description:Binding affinity to VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255048(3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-[(5...)
Affinity DataIC50:  2.00E+4nMAssay Description:Binding affinity to TRAK-A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  2.48E+4nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255012(5-((4-(methylsulfonyl)benzylamino)methyl)-3,4-difl...)
Affinity DataIC50: >3.00E+4nMAssay Description:Binding affinity to SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255012(5-((4-(methylsulfonyl)benzylamino)methyl)-3,4-difl...)
Affinity DataIC50: >3.00E+4nMAssay Description:Binding affinity to ABL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255013((S)-5-((2,4-diamino-4-oxobutanamido)methyl)-3,4-di...)
Affinity DataIC50: >3.00E+4nMAssay Description:Binding affinity to ABL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255012(5-((4-(methylsulfonyl)benzylamino)methyl)-3,4-difl...)
Affinity DataIC50: >3.00E+4nMAssay Description:Binding affinity to LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255013((S)-5-((2,4-diamino-4-oxobutanamido)methyl)-3,4-di...)
Affinity DataIC50: >3.00E+4nMAssay Description:Binding affinity to LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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