Compile Data Set for Download or QSAR
maximum 50k data
Found 87 with Last Name = 'borzillo' and Initial = 'g'
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322393((S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322395((S)-N-((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  1nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322394((S)-N-((3-amino-1-(5-chloro-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322401((S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322397((S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24855(4-{1,2-dihydrospiro[indole-3,4'-piperidine]}-7H-py...)
Affinity DataIC50:  2nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24855(4-{1,2-dihydrospiro[indole-3,4'-piperidine]}-7H-py...)
Affinity DataIC50:  2.40nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322402((S)-N-((3-amino-1-(5-chloro-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322403((S)-N-((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  3nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24848(5-fluoro-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...)
Affinity DataIC50:  3.10nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322398((S)-N-((3-amino-1-(5-chloro-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322388(5-chloro-4-(2,8-diazaspiro[4.5]decan-2-yl)-7H-pyrr...)
Affinity DataIC50:  4nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24847(5-chloro-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...)
Affinity DataIC50:  4.80nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24853(1-{5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...)
Affinity DataIC50:  4.80nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385642(CHEMBL2043435)
Affinity DataIC50:  5nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385635(CHEMBL2043437)
Affinity DataIC50:  5nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385637(CHEMBL2043430)
Affinity DataIC50:  5nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24846(1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-dihydrospi...)
Affinity DataIC50:  5.30nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24852(1-{5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...)
Affinity DataIC50:  5.80nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322403((S)-N-((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322396((S)-N-((3-amino-1-(5-cyano-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322404((S)-N-((3-amino-1-(5-cyano-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322393((S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  9nMAssay Description:Inhibition of AKT2 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322399((S)-N-((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  11.4nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322393((S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  12nMAssay Description:Inhibition of AKT3 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24849(1'-methyl-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-...)
Affinity DataIC50:  12.7nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322412(CHEMBL1171840 | phenyl(3-amino-1-(5-methyl-7H-pyrr...)
Affinity DataIC50:  16nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322400((S)-N-((3-amino-1-(5-cyano-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  17.5nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385643(CHEMBL2043436)
Affinity DataIC50:  20nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385641(CHEMBL2043434)
Affinity DataIC50:  35nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322405(CHEMBL1171672 | N-((3-amino-1-(5-methyl-7H-pyrrolo...)
Affinity DataIC50:  38nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24845(5-chloro-4-{3H,4H,5H,6H,7H-imidazo[4,5-c]pyridin-5...)
Affinity DataIC50:  42nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385638(CHEMBL2043432)
Affinity DataIC50:  43nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322408(CHEMBL1171501 | N-((3-amino-1-(5-methyl-7H-pyrrolo...)
Affinity DataIC50:  44nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385640(CHEMBL2043433)
Affinity DataIC50:  45nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322410((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-...)
Affinity DataIC50:  58nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322411(CHEMBL1171485 | N-((3-amino-1-(5-methyl-7H-pyrrolo...)
Affinity DataIC50:  61nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322407(CHEMBL1171842 | N-((3-amino-1-(5-methyl-7H-pyrrolo...)
Affinity DataIC50:  62nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322391((R)-1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)py...)
Affinity DataIC50:  68nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385644(CHEMBL2043438)
Affinity DataIC50:  72nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385639(CHEMBL2043431)
Affinity DataIC50:  88nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385636(CHEMBL2043429)
Affinity DataIC50:  103nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24841(N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-py...)
Affinity DataIC50:  151nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322409(N-((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin...)
Affinity DataIC50:  160nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24842(N-[4-chloro-2-(5-methyl-4H-1,2,4-triazol-3-yl)phen...)
Affinity DataIC50:  171nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322390((3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)p...)
Affinity DataIC50:  180nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385645(CHEMBL2043439)
Affinity DataIC50:  191nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50322389(1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperi...)
Affinity DataIC50:  200nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24837(N-[2-(4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3...)
Affinity DataIC50:  210nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 87 total ) | Next | Last >>
Jump to: