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Found 115 with Last Name = 'bosserman' and Initial = 'm'
TargetCarboxypeptidase B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144342(3-((1R,3S)-3-Amino-cyclopentyl)-2-[1-(3,3-dimethyl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144333(3-(6-Amino-5-methyl-pyridin-3-yl)-2-[1-(4-methyl-p...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144336(3-(6-Amino-5-methyl-pyridin-3-yl)-2-[1-(3-methyl-b...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144342(3-((1R,3S)-3-Amino-cyclopentyl)-2-[1-(3,3-dimethyl...)
Affinity DataIC50:  1nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144337(3-(6-Amino-pyridin-3-yl)-2-[1-(4-methyl-pentyl)-1H...)
Affinity DataIC50:  2nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135934(3-(6-Amino-pyridin-3-yl)-2-[1-(3-methyl-butyl)-1H-...)
Affinity DataIC50:  2.70nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144337(3-(6-Amino-pyridin-3-yl)-2-[1-(4-methyl-pentyl)-1H...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135934(3-(6-Amino-pyridin-3-yl)-2-[1-(3-methyl-butyl)-1H-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135934(3-(6-Amino-pyridin-3-yl)-2-[1-(3-methyl-butyl)-1H-...)
Affinity DataIC50:  5nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135936(3-(6-Amino-pyridin-3-yl)-2-(1-butyl-1H-imidazol-4-...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135939(3-(4,4-Diamino-but-3-enylsulfanyl)-2-mercaptomethy...)
Affinity DataIC50:  8.20nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144333(3-(6-Amino-5-methyl-pyridin-3-yl)-2-[1-(4-methyl-p...)
Affinity DataIC50:  12nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase M(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135939(3-(4,4-Diamino-but-3-enylsulfanyl)-2-mercaptomethy...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of purified Carboxypeptidase M (CPM) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144316(3-(6-Amino-5-methyl-pyridin-3-yl)-2-(1H-imidazol-4...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135935(3-(6-Amino-pyridin-3-yl)-2-(1-benzyl-1H-imidazol-4...)
Affinity DataIC50:  21nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144336(3-(6-Amino-5-methyl-pyridin-3-yl)-2-[1-(3-methyl-b...)
Affinity DataIC50:  23nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144317(6-Amino-2-[1-(3-methyl-butyl)-1H-imidazol-4-yl]-he...)
Affinity DataIC50:  24nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135940(3-(6-Amino-pyridin-3-yl)-2-(1-ethyl-1H-imidazol-4-...)
Affinity DataIC50:  36nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135937(3-(6-Amino-pyridin-3-yl)-2-(1-methyl-1H-imidazol-4...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135938(3-(6-Amino-pyridin-3-yl)-2-(1-isopropyl-1H-imidazo...)
Affinity DataIC50:  52nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135933(3-(6-Amino-pyridin-3-yl)-2-(1H-imidazol-4-yl)-prop...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135933(3-(6-Amino-pyridin-3-yl)-2-(1H-imidazol-4-yl)-prop...)
Affinity DataIC50:  80nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144316(3-(6-Amino-5-methyl-pyridin-3-yl)-2-(1H-imidazol-4...)
Affinity DataIC50:  100nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144325(3-((1R,3S)-3-Amino-cyclopentyl)-2-(1-ethyl-1H-imid...)
Affinity DataIC50:  100nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144942(2'-C-Me-guanosine | 2'-C-methyl-guanosine | 2'-C-m...)
Affinity DataIC50:  130nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144325(3-((1R,3S)-3-Amino-cyclopentyl)-2-(1-ethyl-1H-imid...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144317(6-Amino-2-[1-(3-methyl-butyl)-1H-imidazol-4-yl]-he...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144322(6-Amino-2-(1H-imidazol-4-yl)-5-methyl-hexanoic aci...)
Affinity DataIC50:  270nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144320(6-Amino-2-(1H-imidazol-4-yl)-5,5-dimethyl-hexanoic...)
Affinity DataIC50:  380nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121929((phenylmethyl)butanedioic acid | 2-benzylbutanedio...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibition of Carboxypeptidase A (CPA) was determined by clot lysis assay using human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144334(6-Amino-2-(1H-imidazol-4-yl)-hexanoic acid | CHEMB...)
Affinity DataIC50:  590nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144320(6-Amino-2-(1H-imidazol-4-yl)-5,5-dimethyl-hexanoic...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144937(2-Amino-9-((2R,3R,5S)-3-hydroxy-5-hydroxymethyl-te...)
Affinity DataIC50:  600nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135933(3-(6-Amino-pyridin-3-yl)-2-(1H-imidazol-4-yl)-prop...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135934(3-(6-Amino-pyridin-3-yl)-2-[1-(3-methyl-butyl)-1H-...)
Affinity DataIC50:  1.40E+3nMAssay Description:In vitro inhibition of Carboxypeptidase A (CPA) was determined by clot lysis assay using human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135934(3-(6-Amino-pyridin-3-yl)-2-[1-(3-methyl-butyl)-1H-...)
Affinity DataIC50:  1.40E+3nMAssay Description:In vitro inhibition of Carboxypeptidase A (CPA) was determined by clot lysis assay using human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144323(3-(6-Amino-4-methyl-pyridin-3-yl)-2-(1H-imidazol-4...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144322(6-Amino-2-(1H-imidazol-4-yl)-5-methyl-hexanoic aci...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121929((phenylmethyl)butanedioic acid | 2-benzylbutanedio...)
Affinity DataIC50:  1.60E+3nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144947(2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50100009(2-(1H-Imidazol-4-yl)-3-phenyl-propionic acid | 2-(...)
Affinity DataIC50:  1.70E+3nMAssay Description:In vitro inhibition of Carboxypeptidase A (CPA) was determined by clot lysis assay using human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144938(2-Amino-9-((2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-hydr...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144948((2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxy...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144949((2R,3R,4R,5R)-2-(2,6-diamino-9H-purin-9-yl)-5-(hyd...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144329(3-Imidazo[1,2-a]pyridin-6-yl-2-(1H-imidazol-4-yl)-...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144334(6-Amino-2-(1H-imidazol-4-yl)-hexanoic acid | CHEMB...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144934((2R,3R,4R,5R)-2-(6-hydroxy-9H-purin-9-yl)-5-(hydro...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144324(7-Amino-2-(1H-imidazol-4-yl)-heptanoic acid | CHEM...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144332(3-(6-Amino-5-chloro-pyridin-3-yl)-2-(1H-imidazol-4...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144339(3-(6-Amino-2-methyl-pyridin-3-yl)-2-(1H-imidazol-4...)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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