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Found 206 with Last Name = 'bourguet' and Initial = 'e'
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246792(CHEMBL508335 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataKi:  8.5nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246792(CHEMBL508335 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataKi:  415nMAssay Description:Inhibition of human recombinant MMP3 catalytic domain by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246792(CHEMBL508335 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataKi:  523nMAssay Description:Inhibition of human recombinant pro-MMP7 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246792(CHEMBL508335 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant pro-MMP1 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant pro-MMP9 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50254779(CHEMBL4061025)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human HDAC1 expressed in human 293T cells preincubated for 15 mins in presence of [3H]acetyl-labeled histones measured after 30 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246792(CHEMBL508335 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant pro-MMP9 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50254779(CHEMBL4061025)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human HDAC2 expressed in human 293T cells preincubated for 15 mins in presence of [3H]acetyl-labeled histones measured after 30 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246791(CHEMBL498915 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human recombinant pro-MMP9 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50135601((S,E)-N1-(3-(1H-indol-3-yl)-1-(methylamino)-1-oxop...)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246792(CHEMBL508335 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50135601((S,E)-N1-(3-(1H-indol-3-yl)-1-(methylamino)-1-oxop...)
Affinity DataIC50:  10nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC8 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246790(CHEMBL488617 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant pro-MMP9 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  13nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50135601((S,E)-N1-(3-(1H-indol-3-yl)-1-(methylamino)-1-oxop...)
Affinity DataIC50:  17nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50135601((S,E)-N1-(3-(1H-indol-3-yl)-1-(methylamino)-1-oxop...)
Affinity DataIC50:  18nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246681(CHEMBL474723 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246797(CHEMBL502674 | N'-{3-(R)-[2-(S)-(2-Phenyl-1H-indol...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant pro-MMP9 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246680(CHEMBL474523 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50254779(CHEMBL4061025)
Affinity DataIC50:  25nMAssay Description:Inhibition of human HDAC4 expressed in human 293T cells preincubated for 15 mins in presence of [3H]acetyl-labeled histones measured after 30 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human recombinant MMP3 catalytic domain by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50:  27nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246792(CHEMBL508335 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant pro-MMP1 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246790(CHEMBL488617 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213416((2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-3-phenylprop-2...)
Affinity DataIC50:  38nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213419((2E)-3-(N-hydroxycarbamoyl)-2-(3-phenylpropylidene...)
Affinity DataIC50:  45nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246798(CHEMBL452947 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246797(CHEMBL502674 | N'-{3-(R)-[2-(S)-(2-Phenyl-1H-indol...)
Affinity DataIC50:  53nMAssay Description:Inhibition of human recombinant MMP3 catalytic domain by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50:  63nMAssay Description:Inhibition of human recombinant HDAC3/NCOR1 co-expressed in insect cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246796(CHEMBL509346 | N'-{3-(E)-[2-(S)-(2-Phenyl-1H-indol...)
Affinity DataIC50:  65nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50254776(CHEMBL2132717)
Affinity DataIC50:  69nMAssay Description:Inhibition of recombinant full length human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected sf9 cells preincubated for 3 hrs follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50254774(CHEMBL277805)
Affinity DataIC50:  69nMAssay Description:Inhibition of human full length C-terminal His-tagged HDAC3/N-terminal GST-tagged human NCOR2 co-expressed in baculovirus infected Sf9 insect cells p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246791(CHEMBL498915 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  79nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50:  80nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246791(CHEMBL498915 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  91nMAssay Description:Inhibition of human recombinant pro-MMP1 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246757(CHEMBL522422 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  92nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246757(CHEMBL522422 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  93nMAssay Description:Inhibition of human recombinant pro-MMP1 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246682(CHEMBL499426 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213418((2E)-3-(N-hydroxycarbamoyl)-2-heptylidenepropionyl...)
Affinity DataIC50:  101nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246794(CHEMBL510694 | N'-{3-(E)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  105nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246791(CHEMBL498915 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant pro-MMP7 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246798(CHEMBL452947 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant pro-MMP1 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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