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Found 734 with Last Name = 'bowen' and Initial = 'wd'
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065136(CHEMBL81455 | N-(2-Azepan-1-yl-ethyl)-4-iodo-N-met...)
Affinity DataKi:  0.140nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000066((2-Azepan-1-yl-ethyl)-[2-(3,4-dichloro-phenyl)-eth...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]-(+) -3PPP from sigma receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065134(CHEMBL309983 | N-(2-Azepan-1-yl-ethyl)-4-bromo-N-m...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000068(CHEMBL142700 | [2-(3,4-Dichloro-phenyl)-ethyl]-met...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]-(+) -3PPP from sigma receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50037480((6R,11S)-6,11-Dimethyl-3-pentyl-1,2,3,4,5,6-hexahy...)
Affinity DataKi:  0.290nMAssay Description:Binding affinity against sigma receptor from guinea pig brain, using [3H](+)-3-PPP as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000776(1-[2-(3,4-Dichloro-phenyl)-ethyl]-4-propyl-piperaz...)
Affinity DataKi:  0.310nMAssay Description:Binding affinity against sigma receptor from guinea pig brain, using [3H](+)-3-PPP as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50068455(CHEMBL342809 | {4-Oxo-4-[4-(3-phenyl-propyl)-piper...)
Affinity DataKi:  0.320nMAssay Description:Binding affinity was tested against sigma-1 receptor in guinea brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000069(CHEMBL20377 | [2-(3,4-Dichloro-phenyl)-ethyl]-meth...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity against sigma receptor from guinea pig brain, using [3H](+)-3-PPP as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000069(CHEMBL20377 | [2-(3,4-Dichloro-phenyl)-ethyl]-meth...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]-(+) -3PPP from sigma receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000078((3,4-Dichloro-benzyl)-methyl-(2-pyrrolidin-1-yl-et...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]-(+) -3PPP from sigma receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000773(1-[2-(3,4-Dichloro-phenyl)-ethyl]-4-(3-fluoro-prop...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity against sigma receptor from guinea pig brain, using [3H](+)-pentazocine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50125092(1-Benzyl-4-(3-methoxy-benzyl)-piperazine | CHEMBL1...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity towards Sigma-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000773(1-[2-(3,4-Dichloro-phenyl)-ethyl]-4-(3-fluoro-prop...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity against sigma receptor from guinea pig brain, using [3H](+)-pentazocine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50454823(CHEMBL3084910)
Affinity DataKi:  0.410nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50454830(CHEMBL3084869)
Affinity DataKi:  0.430nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50125098(1-Benzyl-4-(3-chloro-benzyl)-piperazine | CHEMBL16...)
Affinity DataKi:  0.460nMAssay Description:Binding affinity towards Sigma-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065140(4-Iodo-N-(2-piperidin-1-yl-ethyl)-benzenesulfonami...)
Affinity DataKi:  0.460nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50125099(1-Benzyl-4-(4-methoxy-benzyl)-piperazine | 1-benzy...)
Affinity DataKi:  0.470nMAssay Description:Binding affinity towards Sigma-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50007314(CHEMBL104834 | [2-(3,4-Dichloro-phenyl)-ethyl]-(2-...)
Affinity DataKi:  0.490nMAssay Description:Inhibiton of [3H]-(+)-3-PPP binding to sigma of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50454825(CHEMBL3084878)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000065(CHEMBL141501 | [2-(3,4-Dichloro-phenyl)-ethyl]-eth...)
Affinity DataKi:  0.510nMAssay Description:Displacement of [3H]-(+) -3PPP from sigma receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000769(1-[2-(3,4-Dichloro-phenyl)-ethyl]-4-(5-fluoro-pent...)
Affinity DataKi:  0.520nMAssay Description:Binding affinity against sigma receptor from guinea pig brain, using [3H](+)-pentazocine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50044714(1-Butyl-4-[2-(3,4-dichloro-phenyl)-ethyl]-piperazi...)
Affinity DataKi:  0.550nMAssay Description:Ability to displace [3H](+)-pentazocine at sigma receptor in guinea pig brain membrane was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50125093(1-Benzyl-4-(3,4-dichloro-benzyl)-piperazine | CHEM...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity towards Sigma-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  0.590nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  0.590nMAssay Description:Binding affinity against Muscarinic receptor from rat brain membranes using [3H]pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50454828(CHEMBL3084907)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000067(CHEMBL347514 | [2-(3,4-Dichloro-phenyl)-ethyl]-met...)
Affinity DataKi:  0.620nMAssay Description:Displacement of [3H]-(+) -3PPP from sigma receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065144(CHEMBL79660 | N-(2-Azepan-1-yl-ethyl)-4-bromo-benz...)
Affinity DataKi:  0.630nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50032410(3-Benzyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Affinity DataKi:  0.670nMAssay Description:Binding affinity measured on Sigma receptor type 1 from guinea pig brain membranes using [3H]pentazocine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50036227((2S,6S,11S)-3-Benzyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataKi:  0.670nMAssay Description:Affinity against Sigma opioid receptor type 1 using [3H]-(+)-Pentazocine in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50032410(3-Benzyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Affinity DataKi:  0.670nMAssay Description:Binding affinity measured on Sigma receptor type 1 from guinea pig brain membranes using [3H]pentazocine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50032410(3-Benzyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Affinity DataKi:  0.670nMAssay Description:Binding affinity was measured on Sigma receptor type 1 using [3H]- pentazocine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50036227((2S,6S,11S)-3-Benzyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataKi:  0.670nMAssay Description:Binding affinity at Sigma receptor type 1, displacement of [3H]-(+)-pentazocine from guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000069(CHEMBL20377 | [2-(3,4-Dichloro-phenyl)-ethyl]-meth...)
Affinity DataKi:  0.700nMAssay Description:Inhibition Constant for 4-[125I]-IPBS binding to sigma 1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50068432(1-[2-(3-Nitro-phenyl)-ethyl]-4-(3-phenyl-propyl)-p...)
Affinity DataKi:  0.720nMAssay Description:Binding affinity was tested against sigma-1 receptor in guinea brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000070(CHEMBL143178 | N-[2-(3,4-Dichloro-phenyl)-ethyl]-N...)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]-(+) -3PPP from sigma receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000080(CHEMBL422834 | [2-(3,4-Dichloro-phenyl)-ethyl]-met...)
Affinity DataKi:  0.830nMAssay Description:Displacement of [3H]-(+) -3PPP from sigma receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000074(CHEMBL142596 | [2-(3-Chloro-phenyl)-ethyl]-methyl-...)
Affinity DataKi:  0.840nMAssay Description:Displacement of [3H]-(+) -3PPP from sigma receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50454824(CHEMBL3084909)
Affinity DataKi:  0.850nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000769(1-[2-(3,4-Dichloro-phenyl)-ethyl]-4-(5-fluoro-pent...)
Affinity DataKi:  0.860nMAssay Description:Binding affinity against sigma receptor from guinea pig brain, using [3H](+)-3-PPP as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
National Institute Of Digestive

Curated by ChEMBL
LigandPNGBDBM50000780(2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidin-1...)
Affinity DataKi:  0.890nMAssay Description:Compound was evaluated for binding affinity towards kappa opioid receptor using [3H](-)-U-69,593 in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50082625((2R,6R,11R)-3-Benzyl-11-methyl-1,2,3,4,5,6-hexahyd...)
Affinity DataKi:  0.960nMAssay Description:Affinity against Sigma opioid receptor type 1 using [3H]-(+)-Pentazocine in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50036229((2S,6S,11S)-3-(4-Fluoro-benzyl)-6,11-dimethyl-1,2,...)
Affinity DataKi:  0.970nMAssay Description:Binding affinity at Sigma receptor type 1, displacement of [3H]-(+)-pentazocine from guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50044713(2-[2-(3,4-Dichloro-phenyl)-ethyl]-octahydro-pyrido...)
Affinity DataKi:  0.980nMAssay Description:Ability to displace [3H](+)-pentazocine at sigma receptor in guinea pig brain membrane was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50454829(CHEMBL3084870)
Affinity DataKi:  0.980nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50454827(AMINOBENZTROPINE)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000079(CHEMBL142755 | [2-(3,4-Dichloro-phenyl)-ethyl]-(2-...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-(+) -3PPP from sigma receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50068429(1-[2-(2-Nitro-phenyl)-ethyl]-4-(3-phenyl-propyl)-p...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity was tested against sigma-1 receptor in guinea brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50007316((3,4-Dichloro-benzyl)-methyl-(2-pyrrolidin-1-yl-cy...)
Affinity DataKi:  1.20nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H]-(+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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