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Found 209 with Last Name = 'bowman' and Initial = 'j'
TargetFMRFamide-like neuropeptides 14(Ascaris)
Pharmacia

Curated by PDSP Ki Database
LigandPNGBDBM86059(CAS_6830 | GTP | NSC_6830)
Affinity DataKi:  10.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCapsid scaffolding protein(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Purdue University

LigandPNGBDBM59224(Pepstatin analog, 12)
Affinity DataKi:  96nM IC50:  360nMpH: 5.52Assay Description:A zhang-poorman assay confirms a competitive inhibition mechanism or inhibit HIV-1 PR as a dimerization or mixed type inhibitor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCapsid scaffolding protein(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Purdue University

LigandPNGBDBM59223(Pepstatin analog, 11)
Affinity DataKi:  175nM IC50:  730nMpH: 5.52Assay Description:A zhang-poorman assay confirms a competitive inhibition mechanism or inhibit HIV-1 PR as a dimerization or mixed type inhibitor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCapsid scaffolding protein(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Purdue University

LigandPNGBDBM59213(Pepstatin analog, 1)
Affinity DataKi:  220nM IC50:  350nMpH: 5.52Assay Description:The competitive assay requires two inhibitors to act by a purely competitive mechanism, whereas the binding site of on the inhibitors has been establ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCapsid scaffolding protein(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Purdue University

LigandPNGBDBM59220(Pepstatin analog, 8)
Affinity DataKi:  600nM IC50:  2.90E+3nMpH: 5.52Assay Description:A zhang-poorman assay confirms a competitive inhibition mechanism or inhibit HIV-1 PR as a dimerization or mixed type inhibitor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCapsid scaffolding protein(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Purdue University

LigandPNGBDBM59222(Pepstatin analog, 10)
Affinity DataKi:  650nM IC50:  2.50E+3nMpH: 5.52Assay Description:A zhang-poorman assay confirms a competitive inhibition mechanism or inhibit HIV-1 PR as a dimerization or mixed type inhibitor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCapsid scaffolding protein(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Purdue University

LigandPNGBDBM59219(Pepstatin analog, 7)
Affinity DataKi:  720nM IC50:  2.70E+3nMpH: 5.52Assay Description:A zhang-poorman assay confirms a competitive inhibition mechanism or inhibit HIV-1 PR as a dimerization or mixed type inhibitor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300312(4-amino-1,2,5-oxadiazole-3-carboximidamide | CHEMB...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of N-terminal his-tagged human indoleamine 2,3-dioxygenase expressed in Escherichia coli assessed as N'-formylkynurenine formation by spec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCapsid scaffolding protein(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Purdue University

LigandPNGBDBM59216(Pepstatin analog, 4)
Affinity DataKi:  1.13E+3nM IC50:  4.40E+3nMpH: 5.52Assay Description:The competitive assay requires two inhibitors to act by a purely competitive mechanism, whereas the binding site of on the inhibitors has been establ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50479598(CHEMBL478672)
Affinity DataKi:  1.25E+3nMAssay Description:Inhibition of HIV1 protease dimerization by Zhang-Poorman kinetic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCapsid scaffolding protein(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Purdue University

LigandPNGBDBM59217(Pepstatin analog, 5)
Affinity DataKi:  1.29E+3nM IC50:  4.90E+3nMpH: 5.52Assay Description:The competitive assay requires two inhibitors to act by a purely competitive mechanism, whereas the binding site of on the inhibitors has been establ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50479600(CHEMBL504512)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of HIV1 protease dimerization by Zhang-Poorman kinetic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50479594(CHEMBL510483)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of HIV1 protease dimerization by Zhang-Poorman kinetic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCapsid scaffolding protein(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Purdue University

LigandPNGBDBM59214(Pepstatin analog, 2)
Affinity DataKi:  3.00E+3nM IC50:  5.90E+3nMpH: 5.52Assay Description:The competitive assay requires two inhibitors to act by a purely competitive mechanism, whereas the binding site of on the inhibitors has been establ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50370412(CHEMBL449777)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of HIV1 protease dimerization by Zhang-Poorman kinetic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50479603(CHEMBL446001)
Affinity DataKi:  6.80E+3nMAssay Description:Inhibition of HIV1 protease dimerization by Zhang-Poorman kinetic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50479593(CHEMBL498854)
Affinity DataKi:  8.30E+3nMAssay Description:Inhibition of HIV1 protease dimerization by Zhang-Poorman kinetic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50479592(CHEMBL450301)
Affinity DataKi:  1.69E+4nMAssay Description:Inhibition of HIV1 protease by competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300305(4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2...)
Affinity DataKi:  3.40E+4nMAssay Description:Competitive inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50479599(CHEMBL508493)
Affinity DataKi:  4.01E+4nMAssay Description:Inhibition of HIV1 protease dimerization by Zhang-Poorman kinetic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50479596(CHEMBL454643)
Affinity DataKi:  8.80E+4nMAssay Description:Inhibition of HIV1 protease dimerization by Zhang-Poorman kinetic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50479601(CHEMBL507784)
Affinity DataKi:  5.10E+5nMAssay Description:Inhibition of HIV1 protease dimerization by Zhang-Poorman kinetic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50410179(CHEMBL2096800)
Affinity DataIC50:  0.140nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
LigandPNGBDBM50410179(CHEMBL2096800)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against Gamma-secretase from APP-transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Zoetis Services

US Patent
LigandPNGBDBM185700(US10875847, Compound Oclacitinib | US9161939, 1a |...)
Affinity DataIC50:  9.53nMpH: 7.4Assay Description:Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [852-1142](Homo sapiens (Human))
Zoetis Services

US Patent
LigandPNGBDBM185700(US10875847, Compound Oclacitinib | US9161939, 1a |...)
Affinity DataIC50:  9.53nMpH: 7.4Assay Description:Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300306(4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,...)
Affinity DataIC50:  10nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233431(CHEMBL3979473 | US9789094, 5)
Affinity DataIC50:  11nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50410182(CHEMBL2096799)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300306(4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,...)
Affinity DataIC50:  12nMAssay Description:Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50410183(CHEMBL2096801)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233424(CHEMBL4076756)
Affinity DataIC50:  14nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150691(311951 | CHEMBL437635)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233430(CHEMBL3955791 | US11207302, Example 2)
Affinity DataIC50:  16nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300299(4-Amino-N-(3-bromophenyl)-N'-hydroxy-1,2,5-oxadiaz...)
Affinity DataIC50:  17nMAssay Description:Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233429(CHEMBL4083203)
Affinity DataIC50:  17nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2 [809-1153](Homo sapiens (Human))
Zoetis Services

US Patent
LigandPNGBDBM185700(US10875847, Compound Oclacitinib | US9161939, 1a |...)
Affinity DataIC50:  17.5nMpH: 7.4Assay Description:Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Zoetis Services

US Patent
LigandPNGBDBM185700(US10875847, Compound Oclacitinib | US9161939, 1a |...)
Affinity DataIC50:  17.5nMpH: 7.4Assay Description:Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300296(4-Amino-N-(3-chlorophenyl)-N'-hydroxy-1,2,5-oxadia...)
Affinity DataIC50:  19nMAssay Description:Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300305(4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2...)
Affinity DataIC50:  19nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300305(4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2...)
Affinity DataIC50:  19nMAssay Description:Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233428(CHEMBL4072733)
Affinity DataIC50:  22nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150696(CHEMBL436787 | methyl 2-[(2R,3R)-2-[(2R)-2-{2-[(2R...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150689(311952 | CHEMBL411599)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50410178(CHEMBL2096802)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233433(CHEMBL4085426)
Affinity DataIC50:  35nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Zoetis Services

US Patent
LigandPNGBDBM185701(US9161939, 2 | US9271981, 2)
Affinity DataIC50:  45nMpH: 7.4Assay Description:Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [852-1142](Homo sapiens (Human))
Zoetis Services

US Patent
LigandPNGBDBM185701(US9161939, 2 | US9271981, 2)
Affinity DataIC50:  45nMpH: 7.4Assay Description:Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Mus musculus)
Incyte

Curated by ChEMBL
LigandPNGBDBM50300305(4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2...)
Affinity DataIC50:  46nMAssay Description:Inhibition of indoleamine 2,3-dioxygenase in mouse B16 cells assessed as kynurenine formation by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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