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Found 61 with Last Name = 'boyden' and Initial = 't'
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM107767(US11419874, PF-05180999 | US8598155, 2)
Affinity DataKi:  4.20nMAssay Description:Displacement of radiolabeled 4-(azetidin-1-yl)-3-[5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]-1-(tritritiomethyl)pyrazolo[3,4-d]pyrimidine from PD...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of PDE5A1 (unknwon origin) using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM107776(US8598155, 13)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50247533(CHEMBL4080109)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM9049(US11419874, Example 15 | US8829010, 35 | US8829010...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM107767(US11419874, PF-05180999 | US8598155, 2)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM9049(US11419874, Example 15 | US8829010, 35 | US8829010...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM130958(US8829010, 9)
Affinity DataIC50:  2nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM130982(US8829010, 33)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM130966(US8829010, 17)
Affinity DataIC50:  3.60nMAssay Description:The inhibition activity of 5-HT1A at 1 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM130956(US8829010, 7)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385642(CHEMBL2043435)
Affinity DataIC50:  5nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385635(CHEMBL2043437)
Affinity DataIC50:  5nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385637(CHEMBL2043430)
Affinity DataIC50:  5nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM130989(US8829010, 40)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239842(CHEMBL4085594)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239841(CHEMBL4101083)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM107770(US8598155, 5)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50247536(CHEMBL3769434)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of PDE5A1 (unknwon origin) using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM130986(US8829010, 37)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM130953(US8829010, 4)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM130953(US8829010, 4)
Affinity DataIC50:  9nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239845(CHEMBL4083369)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50247534(CHEMBL4081035)
Affinity DataIC50:  11nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50247537(CHEMBL4086493)
Affinity DataIC50:  12nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM130951(US8829010, 1)
Affinity DataIC50:  18nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385643(CHEMBL2043436)
Affinity DataIC50:  20nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239847(CHEMBL4080861)
Affinity DataIC50:  24nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239846(CHEMBL4070209)
Affinity DataIC50:  28nMAssay Description:Affinity for adenosine A1 receptor using [3H]N6-(phenylisopropyl)adenosine (R)-[3H]-PIA as a radioligand in rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385641(CHEMBL2043434)
Affinity DataIC50:  35nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385638(CHEMBL2043432)
Affinity DataIC50:  43nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385640(CHEMBL2043433)
Affinity DataIC50:  45nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239850(CHEMBL4095252)
Affinity DataIC50:  67nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50247535(CHEMBL4099071)
Affinity DataIC50:  72nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385644(CHEMBL2043438)
Affinity DataIC50:  72nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385639(CHEMBL2043431)
Affinity DataIC50:  88nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385636(CHEMBL2043429)
Affinity DataIC50:  103nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239843(CHEMBL4099808)
Affinity DataIC50:  109nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239848(CHEMBL4098897)
Affinity DataIC50:  115nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239852(CHEMBL4073717)
Affinity DataIC50:  146nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239838(CHEMBL4071586)
Affinity DataIC50:  189nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50385645(CHEMBL2043439)
Affinity DataIC50:  191nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239855(CHEMBL4072920)
Affinity DataIC50:  241nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239853(CHEMBL4091149)
Affinity DataIC50:  298nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239851(CHEMBL4074798)
Affinity DataIC50:  390nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239840(CHEMBL4093342)
Affinity DataIC50:  423nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239844(CHEMBL4061541)
Affinity DataIC50:  566nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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